Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages DOI Creative Commons
Degao Chen, Xiaomei Zhang, Zhongjun Li

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 11(3), P. 1016 - 1030

Published: Nov. 6, 2020

Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) mediate immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in suppression. To reverse this disorder, regulatory mechanism TAMs TME needs be clarified. Immune molecules (cytokines chemokines) have been widely accepted as mutual mediators signal transduction past few decades. Recently, researchers tried seek intrinsic TAM phenotypic functional changes through metabolic connections. Numerous metabolites derived identified that induce cell-cell crosstalk with TAMs. bulk cells, stromal cells produce are involved regulation Meanwhile, some regulate biological functions well. Here, we review recent reports demonstrating between

Language: Английский

Myeloid Cell-Derived Arginase in Cancer Immune Response DOI Creative Commons
Tomasz M. Grzywa, Anna Sosnowska, Paweł Matryba

et al.

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: May 15, 2020

Amino acid metabolism is a critical regulator of the immune response, and its modulating becomes promising approach in various forms immunotherapy. Insufficient concentrations essential amino acids restrict T-cells activation proliferation. However, only arginases, that degrade ʟ-arginine, as well enzymes hydrolyze ʟ-tryptophan are substantially increased cancer. Two arginase isoforms, ARG1 ARG2, have been found to be present tumors their activity usually correlates with more advanced disease worse clinical prognosis. Nearly all types myeloid cells were reported produce arginases numbers populations myeloid-derived suppressor macrophages correlate inferior outcomes cancer patients. Here, we describe role produced by regulating cells, discuss molecular mechanisms immunoregulatory processes involving ʟ-arginine outline therapeutic approaches mitigate negative effects on antitumor response. Development potent inhibitors, improved pharmacokinetic properties, may lead development novel strategies based targeting pathways controlled degradation.

Language: Английский

Citations

310
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast DOI Creative Commons
Bhupinder Pal, Yunshun Chen, François Vaillant

et al.

The EMBO Journal, Journal Year: 2021, Volume and Issue: 40(11)

Published: May 5, 2021

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1

Language: Английский

Citations

310
A timeline of tumour-associated macrophage biology DOI
Luca Cassetta, Jeffrey W. Pollard

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(4), P. 238 - 257

Published: Feb. 15, 2023

Language: Английский

Citations

280
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy DOI Creative Commons
Chirag Krishna, Renzo G. DiNatale, Fengshen Kuo

et al.

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(5), P. 662 - 677.e6

Published: April 16, 2021

Language: Английский

Citations

279
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages DOI Creative Commons
Degao Chen, Xiaomei Zhang, Zhongjun Li

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 11(3), P. 1016 - 1030

Published: Nov. 6, 2020

Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) mediate immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in suppression. To reverse this disorder, regulatory mechanism TAMs TME needs be clarified. Immune molecules (cytokines chemokines) have been widely accepted as mutual mediators signal transduction past few decades. Recently, researchers tried seek intrinsic TAM phenotypic functional changes through metabolic connections. Numerous metabolites derived identified that induce cell-cell crosstalk with TAMs. bulk cells, stromal cells produce are involved regulation Meanwhile, some regulate biological functions well. Here, we review recent reports demonstrating between

Language: Английский

Citations

263