Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion DOI Creative Commons

Xixi Liu,

Kenneth K.W. To,

Qinsong Zeng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark cancer. Antitumor refers to innate adaptive immune responses that regulate development proliferation. Tumor evasion represents major hindrance effective anticancer treatment. Extracellular vesicles (EVs) are nano-sized lipid-bilayer-enclosed particles secreted extracellular space by all cell types. They critically involved numerous biological functions including intercellular communication. Tumor-derived (TEVs) can transport variety cargo modulate cells microenvironment (TME). This review provides latest update about how evade surveillance exploiting TEVs. First, biogenesis EVs cargo-sorting machinery discussed. Second, differentiation, activation, function via TEVs illustrated. Last but not least, novel antitumor strategies reverse escape summarized.

Language: Английский

The cancer-immunity cycle: Indication, genotype, and immunotype DOI Creative Commons
Ira Mellman, Daniel S. Chen, Thomas Powles

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2188 - 2205

Published: Oct. 1, 2023

The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.

Language: Английский

Citations

393
CD8+ T cells in the cancer-immunity cycle DOI Creative Commons
Josephine R. Giles, Anna-Maria Globig,

Susan M. Kaech

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2231 - 2253

Published: Oct. 1, 2023

Language: Английский

Citations

177
Roles of macrophages in tumor development: a spatiotemporal perspective DOI Creative Commons

Mathilde Bied,

William W. Ho, Florent Ginhoux

et al.

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(9), P. 983 - 992

Published: July 10, 2023

Abstract Macrophages are critical regulators of tissue homeostasis but also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support development. While we know that TAMs dominant immune cells TME, their vast heterogeneity associated functions only just being unraveled. this review, outline various known TAM populations found thus far delineate specialized roles with main stages cancer progression. We discuss how may prime premetastatic niche enable growth a metastasis then subsequent metastasis-associated can secondary growth. Finally, speculate on challenges remain be overcome research.

Language: Английский

Citations

148
Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

111
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells DOI Creative Commons
Ning‐Ning Liu, Chengxiang Yi,

Luqi Wei

et al.

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(11), P. 1927 - 1944.e9

Published: Sept. 21, 2023

Language: Английский

Citations

87
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics DOI Creative Commons
Jai Prakash, Yuval Shaked

Cancer Discovery, Journal Year: 2024, Volume and Issue: 14(8), P. 1375 - 1388

Published: Aug. 2, 2024

Abstract The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors known to support tumor progression and metastasis. interplay between the ECM cancer therapeutics opens up new avenues in understanding biology. While protect from anticancer agents by serving as a biomechanical barrier, emerging studies show that various therapies induce remodeling, resulting therapy resistance progression. This review discusses critical issues this field including how influences treatment outcome, affect challenges associated with targeting ECM. Significance: intricate relationship reveals novel insights into biology its effective treatment. may anti-cancer agents, recent research highlights paradoxical role therapy-induced remodeling promoting explores key aspects therapeutics.

Language: Английский

Citations

56
The role of tumor-associated macrophages in tumor immune evasion DOI Creative Commons

Ruizhe Huang,

Ting Kang, Siyu Chen

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Language: Английский

Citations

54
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization DOI Creative Commons
Wenying Wang, Tianran Li, Yue Cheng

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(5), P. 815 - 832.e12

Published: April 18, 2024

Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes endothelial adherens junctions activating adrenomedullin paracrine signaling, thereby stimulating hyperpermeable neovasculature hampers drug delivery in glioblastoma xenografts. Accordingly, genetic ablation pharmacological blockade produced restores vascular integrity, improves intratumoral concentration anti-tumor agent dabrafenib, achieves combinatorial therapeutic benefits. Increased proportion expression predictive tumor vessel hyperpermeability worse prognosis glioblastoma. Our findings highlight diversity spatial niche-steered reprogramming indicate potential therapeutics targeting normalize vasculature.

Language: Английский

Citations

53
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies DOI Creative Commons

Ibraheem Nasir,

Conor McGuinness, Ashleigh R. Poh

et al.

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(12), P. 971 - 985

Published: Nov. 22, 2023

Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting macrophages has historically focused on inhibiting their recruitment or reprogramming phenotype from protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) spatial transcriptomics improved our understanding ontogeny, phenotype, functional plasticity macrophages. Overlaying wealth current information regarding macrophage molecular subtypes functions also identified novel therapeutic vulnerabilities might drive better control tumor-associated (TAMs). Here, we discuss profiling provide update macrophage-targeted therapies in development.

Language: Английский

Citations

46
Radiotherapy and immunology DOI Creative Commons
Liangliang Wang, Connor Lynch, Sean P. Pitroda

et al.

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)

Published: May 21, 2024

The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity ultimately enhance adaptive immunity. In opposition, also induces suppression immunity, including recruitment regulatory T cells, myeloid-derived suppressor suppressive macrophages. balance pro- is regulated by chemokines cytokines. Microbiota can influence outcomes under clinical investigation. Blockade PD-1/PD-L1 axis CTLA-4 extensively investigated combination radiotherapy; we include review trials involving inhibition these checkpoints radiotherapy.

Language: Английский

Citations

32