Oxidative Stress in Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(2), P. 167 - 197

Published: July 9, 2020

Language: Английский

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Cancer metabolism: looking forward

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(10), P. 669 - 680

Published: July 16, 2021

Language: Английский

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The role of ROS in tumour development and progression

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(5), P. 280 - 297

Published: Jan. 31, 2022

Language: Английский

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The hallmarks of cancer metabolism: Still emerging

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(3), P. 355 - 377

Published: Feb. 4, 2022

Language: Английский

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p53: 800 million years of evolution and 40 years of discovery

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(8), P. 471 - 480

Published: May 13, 2020

Language: Английский

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The Complex Interplay between Antioxidants and ROS in Cancer

Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(6), P. 440 - 451

Published: April 14, 2020

Language: Английский

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Cells, Journal Year: 2020, Volume and Issue: 9(10), P. 2308 - 2308

Published: Oct. 16, 2020

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, stem cells. Well-known oncogenic signaling phosphoinositide 3-kinase (PI3K)/AKT, Myc, Hippo pathway, mediate metabolic gene expression increase enzyme activities. Vice versa, deregulated pathways contribute to defects cellular signal transduction which turn provide energy, building blocks, redox potentials for unrestrained cell proliferation. Studies clinical trials are being performed that focus on the inhibition enzymes by small molecules or dietary interventions (e.g., fasting, calorie restriction, intermittent fasting). Similar genetic heterogeneity, phenotypes cancers highly heterogeneous. This heterogeneity results from diverse cues tumor microenvironment mutations. Hence, overcoming plasticity an goal modern therapeutics. review highlights recent findings elucidates interactions between pathways. We also novel rationales designing next-generation drugs.

Language: Английский

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Metastasis

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

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Metabolic programming and immune suppression in the tumor microenvironment

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 421 - 433

Published: Feb. 16, 2023

Language: Английский

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Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Cancer Discovery, Journal Year: 2020, Volume and Issue: 10(12), P. 1797 - 1807

Published: Nov. 3, 2020

Cancer cells continuously rewire their metabolism to fulfill need for rapid growth and survival while subject changes in environmental cues. Thus, a vital component of cancer cell lies its metabolic adaptability. The constant demand alterations requires flexibility, that is, the ability utilize different substrates; as well plasticity, process substrates ways. In this review, we discuss how dynamic affect tumor progression consequential implications therapy. SIGNIFICANCE: Recognizing adaptability an entity can lead targeted therapy is expected decrease drug resistance.

Language: Английский

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