International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(10), P. 4101 - 4117
Published: Jan. 1, 2022
The
impact
of
the
gut
microbiome
on
host
health
is
becoming
increasingly
recognized.To
date,
there
growing
evidence
that
complex
characteristics
microbial
community
play
key
roles
as
potential
biomarkers
and
predictors
responses
in
cancer
therapy.Many
studies
have
shown
altered
commensal
bacteria
lead
to
susceptibility
progression
diverse
pathways.In
this
review,
we
critically
assess
data
for
microbiota
related
gastrointestinal
cancer,
including
esophageal,
gastric,
pancreatic,
colorectal
hepatocellular
carcinoma
cholangiocarcinoma.Importantly,
underlying
mechanisms
involved
occurrence,
prevention
treatment
are
elucidated.The
purpose
review
provide
novel
insights
applying
understanding
development
new
therapeutic
strategies
by
targeting
community.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
Abstract
KRAS
is
one
of
the
most
mutated
genes,
driving
alternations
in
metabolic
pathways
that
include
enhanced
nutrient
uptaking,
increased
glycolysis,
elevated
glutaminolysis,
and
heightened
synthesis
fatty
acids
nucleotides.
However,
beyond
mechanisms
KRAS-modulated
cancer
metabolisms
remain
incompletely
understood.
In
this
review,
we
aim
to
summarize
current
knowledge
on
KRAS-related
alterations
cells
explore
prevalence
significance
mutation
shaping
tumor
microenvironment
influencing
epigenetic
modification
via
various
molecular
activities.
Given
rely
these
changes
sustain
cell
growth
survival,
targeting
processes
may
represent
a
promising
therapeutic
strategy
for
KRAS-driven
cancers.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 15, 2025
The
polymorphic
microbiome
is
considered
a
new
hallmark
of
cancer.
Advances
in
High-Throughput
Sequencing
have
fostered
rapid
developments
research.
interaction
between
cancer
cells,
immune
and
microbiota
defined
as
the
immuno-oncology
(IOM)
axis.
Fungal
microbes
(the
mycobiome),
although
representing
only
∼
0.1-1%
microbiome,
are
critical
immunologically
active
component
tumor
microbiome.
Accumulating
evidence
suggests
possible
involvement
commensal
pathogenic
fungi
initiation,
progression,
treatment
responsiveness.
tumor-associated
mycobiome
mainly
consists
gut
mycobiome,
oral
intratumoral
mycobiome.
However,
role
remains
poorly
understood,
diversity
complexity
analytical
methods
make
it
challenging
to
access
this
field.
This
review
aims
elucidate
causal
complicit
roles
development
progression
while
highlighting
issues
that
need
be
addressed
executing
such
We
systematically
summarize
advantages
limitations
current
fungal
detection
analysis
methods.
enumerate
integrate
these
recent
findings
into
our
understanding
accompanied
by
prospect
novel
exhilarating
clinical
implications.
Gut,
Journal Year:
2022,
Volume and Issue:
71(10), P. 2107 - 2122
Published: July 12, 2022
Cancer
is
generally
regarded
as
a
localised
disease,
with
the
well-established
role
of
tumour
microenvironment.
However,
realm
cancer
goes
beyond
microenvironment,
and
should
also
be
systemic
environmental
disease.
The
exposome
(
ie,
totality
exposures),
which
encompasses
diets,
supplements,
smoking,
alcohol,
other
lifestyle
factors,
medications,
etc
,
likely
alters
microbiome
(inclusive
bacteria,
viruses,
archaea,
fungi,
parasites,
)
immune
system
in
various
body
sites
influences
phenotypes.
metabolic/inflammatory
status,
influenced
by
exposures
intestinal
physiological
changes,
may
affect
tissue
microenvironment
colorectum
any
organs.
Germline
genomic
factors
can
modify
disease
phenotypes
via
gene-by-environment
interactions.
Although
challenges
exist,
it
crucial
to
advance
not
only
basic
experimental
research
that
analyse
effects
exposures,
microorganisms
microenvironmental
components
on
evolution
but
interdisciplinary
human
population
dissect
complex
pathogenic
roles
exposome,
immunome.
Metagenomic,
metatranscriptomic
metabolomic
analyses
integrated
into
well-designed
combined
advanced
methodologies
artificial
intelligence
molecular
pathological
epidemiology.
Ideally,
prospective
cohort
study
design
enables
biospecimen
(such
stool)
collection
before
detection
considered
address
reverse
causation
recall
biases.
Robust
observational
together
provide
insights
dynamic
interactions
between
microbiota,
immunity
during
carcinogenesis
processes,
thereby
helping
us
develop
precision
prevention
therapeutic
strategies
ultimately
reduce
burden.
International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(10), P. 4101 - 4117
Published: Jan. 1, 2022
The
impact
of
the
gut
microbiome
on
host
health
is
becoming
increasingly
recognized.To
date,
there
growing
evidence
that
complex
characteristics
microbial
community
play
key
roles
as
potential
biomarkers
and
predictors
responses
in
cancer
therapy.Many
studies
have
shown
altered
commensal
bacteria
lead
to
susceptibility
progression
diverse
pathways.In
this
review,
we
critically
assess
data
for
microbiota
related
gastrointestinal
cancer,
including
esophageal,
gastric,
pancreatic,
colorectal
hepatocellular
carcinoma
cholangiocarcinoma.Importantly,
underlying
mechanisms
involved
occurrence,
prevention
treatment
are
elucidated.The
purpose
review
provide
novel
insights
applying
understanding
development
new
therapeutic
strategies
by
targeting
community.
