Chemistry - An Asian Journal,
Journal Year:
2021,
Volume and Issue:
16(20), P. 3068 - 3081
Published: Aug. 23, 2021
Abstract
2‐Pyrrolidones
have
aroused
enormous
interest
as
a
useful
structural
moiety
in
drug
discovery;
however,
not
only
does
their
syntheses
suffer
from
low
selectivity
and
yield,
but
also
it
requires
high
catalyst
loadings.
The
radical
cyclization
of
1,
n
‐enynes
‐dienes
has
demonstrated
to
be
an
attractive
method
for
the
synthesis
2‐pyrrolidones
due
its
mild
reaction
conditions,
fewer
steps,
higher
atom
economy,
excellent
functional
group
compatibility,
regioselectivity.
Furthermore,
receptors
with
unsaturated
bonds
(i.
e.
‐dienes)
play
crucial
role
realizing
because
ability
selectively
introduce
one
or
more
sources.
In
this
review,
we
discuss
representative
examples
methods
involving
published
last
five
years
each
prominent
design
mechanism,
providing
favorable
tools
valuable
2‐pyrrolidone
variety
applications.
Chinese Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
42(12), P. 4292 - 4292
Published: Jan. 1, 2022
Pyrazoles
are
the
most
important
five-membered
N-heterocycles
as
they
present
in
many
natural
products
and
synthetic
drugs.Among
various
pyrazole
derivatives,
4-bromopyrazoles
have
attracted
great
attention
because
not
only
display
significant
biological
activities
physicochemical
properties
but
also
serve
valuable
synthons
organic
chemistry.In
this
manuscript,
an
efficient
eco-friendly
method
for
synthesis
of
through
threecomponent
reaction
hydrazine,
acetylacetone
2-bromomalonate
was
reported
proposal
mechanism
revealed.According
to
mechanism,
hydrazine
reacts
with
afford
firstly,
which
then
converts
4-bromopyrazole
bromination.This
could
be
well
applicable
bromination
other
heterocyclic
compounds.Given
high
oxidation
state
diethyl
2-bromomalonate,
peroxidation
can
avoided
electrolysis
process,
thus
excess
amount
brominating
agent
required.
Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(4), P. 1416 - 1416
Published: Jan. 1, 2023
CO2
is
an
important
C1
source
in
organic
synthesis
due
to
its
abundant,
non-toxic
and
low-cost
properties.Therefore,
it
of
great
significance
use
as
a
synthesize
compounds
with
high
added
value.This
review
focuses
on
the
recent
progress
carboxylation
using
electrophile
under
electrochemical
conditions.The
non-activated
halides,
unsaturated
alkene
some
special
are
mainly
introduced.And
sacrificial
anodes
non-sacrificial
classified
detail.The
reaction
mechanisms
these
reactions
also
discussed.This
provides
reference
for
application
such
future.
Chemistry - An Asian Journal,
Journal Year:
2021,
Volume and Issue:
16(20), P. 3068 - 3081
Published: Aug. 23, 2021
Abstract
2‐Pyrrolidones
have
aroused
enormous
interest
as
a
useful
structural
moiety
in
drug
discovery;
however,
not
only
does
their
syntheses
suffer
from
low
selectivity
and
yield,
but
also
it
requires
high
catalyst
loadings.
The
radical
cyclization
of
1,
n
‐enynes
‐dienes
has
demonstrated
to
be
an
attractive
method
for
the
synthesis
2‐pyrrolidones
due
its
mild
reaction
conditions,
fewer
steps,
higher
atom
economy,
excellent
functional
group
compatibility,
regioselectivity.
Furthermore,
receptors
with
unsaturated
bonds
(i.
e.
‐dienes)
play
crucial
role
realizing
because
ability
selectively
introduce
one
or
more
sources.
In
this
review,
we
discuss
representative
examples
methods
involving
published
last
five
years
each
prominent
design
mechanism,
providing
favorable
tools
valuable
2‐pyrrolidone
variety
applications.
