Chemistry - A European Journal,
Journal Year:
2022,
Volume and Issue:
29(5)
Published: Nov. 3, 2022
Organic
ultralong
room-temperature
phosphorescence
(RTP)
materials
have
attracted
great
attention
for
their
wide
applications
in
optoelectronic
devices
and
bioimaging.
However,
the
development
of
these
remains
a
challenging
task,
partially
due
to
lack
rational
molecular
design
strategies
unclear
luminescence
mechanisms.
Herein,
we
present
method
facile
access
structurally
diverse
substituted
1-aminoisoquinoline
derivatives
through
copper-catalyzed
one-pot
three-component
coupling
reaction
that
provides
promising
approach
rapidly
assemble
library
1-aminoisoquinolines
exploring
regularity
host-guest
doped
system.
A
series
RTP
with
wide-ranging
lifetimes
from
4.4
299.3
ms
were
constructed
by
doping
various
isoquinolines
into
benzophenone
(BP).
Furthermore,
4
r/BP
nanoparticles
could
be
used
in-vivo
imaging
signal-to-noise
ratio
value
as
high
32,
revealing
potential
isoquinoline
framework
construction
high-performance
materials.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(7), P. 1522 - 1527
Published: Feb. 13, 2024
Two
distinct
TMSOTf-catalyzed
annulation
reactions
between
ynamides
and
1,2-benzisothiazoles
have
been
developed.
The
direction
of
the
reaction
could
be
easily
switched
by
applying
different
thermodynamic-controlled
conditions.
At
room
temperature,
undergo
a
[5
+
2]
with
to
afford
1,4-benzothiazepines,
whereas
under
heating
conditions
desulfurizative
proceeds
well
access
3-aminoisoquinolines.
These
two
protocols
provide
biologically
important
1,4-benzothiazepines
3-aminoisoquinolines
high
efficiency
broad
substrate
scopes
mild
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
A
divergent
[5
+
1]
cyclization
reaction
of
o-aminobenzamides
with
vinylene
carbonate
has
been
developed,
rapidly
generating
three
types
cyclic
molecules
including
quinazolinones,
2-methylquinazolinones,
and
2,3-dihydroquinazolinones
high
chemoselectivity.
In
this
discovery,
blooms
as
a
multifunctional
reagent
to
participate
in
cyclization.
The
potential
new
finding
is
further
emphasized
by
assembling
the
benzothiazole
heteroarene
via
[4
version
tolerating
bioactive
units
well.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(8), P. 1719 - 1724
Published: Jan. 1, 2023
An
oxidative
annulation
of
N-arylbenzimidamides
with
maleimides
has
been
developed
for
the
first
time
using
a
catalytic
amount
[Cp*RhCl2]2
complex
synthesis
diverse
range
1H-benzo[4,5]imidazo[2,1-a]pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
derivatives.
This
method
is
versatile
and
atom-economical
producing
polycyclic
benzo[4,5]imidazo[2,1-a]pyrrolo[3,4-c]
isoquinoline-1,3(2H)-dione
scaffolds
in
single
step.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2509 - 2534
Published: Jan. 1, 2023
This
review
will
be
an
essential
toolbox
for
medicinal
and
bioorganic
chemists
seeking
novel
multifunctional
hybrid
bioactive
N-heterocycles
drug
discovery.
The
work
highlights
the
need
relevance
of
unexplored
bioisosterism
employing
isoquinoline-based
small-molecules
in
design.
Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(10), P. 2557 - 2561
Published: Sept. 3, 2021
Abstract
A
Rh‐catalyzed
divergent
alkylation
of
indole
derivatives
with
vinyl
carbonate
was
described.
Depending
on
the
substrate
and
solvent,
indoles
reacted
alcohols
to
give
C2
carboxymethylated
adducts
via
a
sequential
three‐component
reaction,
while
indolines
in
toluene
provide
C7
formylmethylated
products.
The
structures
product
3
5
were
further
confirmed
by
X‐ray
analysis.
current
protocol
featured
broad
scope,
tunable
reaction
conditions,
functionalization,
good
regioselectivity.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(7), P. 4804 - 4809
Published: Jan. 1, 2024
The
step-economical
synthesis
of
C2,
C3-unsubstituted
1-aminoindole
derivatives
through
rhodium-catalyzed
annulation
hydrazines
with
vinylene
carbonate.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(50), P. 10951 - 10957
Published: Dec. 10, 2024
Molecular
editing
of
quinazolinones
to
isoquinolines
by
a
novel
ruthenium-catalyzed
[4+2]
annulation
with
sulfoxonium
ylides
has
been
developed.
The
method
permits
the
precise
and
rapid
assembly
multisubstituted
aminoisoquinolines,
class
heterocycles
that
play
privileged
role
in
organic
synthesis
pharmaceutical
development.
This
new
catalytic
process
exhibits
programmability,
including
directed
C–H
acetylation,
nucleophilic
cyclization,
alcoholysis.
Remarkably,
various
2-arylquinazolinones
could
be
employed
excellent
yields
broad
functional
group
tolerance.
heterocycle-to-heterocycle
protocol
is
compatible
green
chemistry
using
an
EtOH
solvent
releasing
H2O
dimethyl
sulfoxide
as
byproducts.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(19)
Published: April 21, 2022
Abstract
A
rhodium‐catalyzed
C−H
activation/annulation
of
N
‐aryl‐pyrazolidinones
with
vinylene
carbonate
was
developed.
The
utilization
as
the
acetylene
surrogate
furnished
successful
construction
non‐substituted
5,6‐pyrazolo[1,2‐
a
]cinnoline
derivatives,
which
are
difficult
to
synthesize
through
other
procedures.
In
this
work,
series
variously
substituted
pyrazolo[1,2‐
]cinnolines
were
obtained
in
yields
up
98
%
broad
substrate
scope
and
excellent
selectivity.
Moreover,
external
oxidants
not
required
protocol
H
2
O
CO
clean
by‐products.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
10(1), P. 62 - 67
Published: Nov. 8, 2022
A
substrate-controlled
Ru(
ii
)-catalyzed
C–H
activation/[5
+
2]
annulation
cascade
and
unusual
acyl
migration
to
synthesize
diverse
indoline
scaffolds
are
reported.
