Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis DOI
Li Cai,

Pengfei Xiong,

Tao Li

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 271, P. 116417 - 116417

Published: April 16, 2024

Language: Английский

1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity DOI

Yinling Wei,

Sheng Li,

Hongyan Wen

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 222, P. 114093 - 114093

Published: April 12, 2024

Language: Английский

Citations

6
Mn(OAc)3 promoted radical cyclization of vinyl isocyanides: Synthesis of isoquinoline-1-sulfonates and derivatives DOI
Xin Gu, Yan Zhang, Ruiming Zhang

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155629 - 155629

Published: May 1, 2025

Language: Английский

Citations

0
Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes DOI Creative Commons

T. Sumitha Celin,

G. Allen Gnana Raj,

Thimma Subramanian Prathima

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 3, 2025

The photophysical properties of tris(polypyridyl)ruthenium(II) complex [Ru(dmbpy) 3 ] 2+ [dmbpy = 4,4′-dimethyl-2,2′-bipyridine] were investigated and compared with [Ru(bpy) following both experimental computational approaches. variations in the electronic ground excited states determined by density functional theory (DFT) methods, their effects on anticancer, antioxidant, antimicrobial activities also evaluated molecular docking dynamic simulation studies. potential these complexes to serve as bioanalytes was ability bind quinones, well-known electron mediators numerous light-driven reactions. Following above, anticancer against breast cancer-related proteins. results revealed that possesses comparable antioxidant . physical, electronic, biological this depend nature ligands medium investigation. Herein, applications clinical diagnostics antioxidants therapeutic agents evaluated.

Language: Английский

Citations

0
Synthesis, antibacterial evaluation and preliminary mechanism study of novel isoquinoline‐3‐carboxylic acid derivatives containing an acylhydrazone disulfone moiety DOI Open Access
Shangde Sun, Ping Fang, Zhiyuan Xu

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Limitations in the use and availability of copper-based fungicides antibiotics has led to a scarcity bactericidal agents. It is urgent develop green bactericides with new modes-of-action effective chemotypes. A bioactive substructure splicing approach was applied optimize structure natural product isoquinolin-3-carboxylic acid (IQ3CA). The structure-activity relationship analysis showed that increase sulfur atomic oxidation state small groups on sulfone will be beneficial for antibacterial activities. difulone compound SF2 most potent activity against Xanthomonas oryzae pv. (Xoo), Ralstonia solanacearum (Rs) Acidovorax citrulli (Ac), median lethal concentration values 2.52, 2.62 1.12 μg mL-1, respectively, which were superior those IQ3CA kasugamycin. protective curative effects Ac 69.31% 55.64%, better than thiodiazole copper (58.37% 43.08%). Furthermore, preliminary mechanistic investigations indicated could membrane permeability, reduce exopolysaccharide content, inhibit both bacterial motility biofilm formation. series novel isoquinoline-3-acylhydrazone derivatives incorporating thioether/disulfone moieties synthesized, bioassay results demonstrated remarkable by disrupting membranes. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
One-pot multistep synthesis of 1-fluoroalkylisoquinolines and fused fluoroalkylpyridines from N-fluoroalkyl-1,2,3-triazoles DOI Creative Commons
Anna Kubíčková, S. Voltrová, Adam F. Kleman

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(16), P. 4442 - 4448

Published: Jan. 1, 2024

Microwave heating of N -fluoroalkyl-1,2,3-triazoles proceeding via ketenimines and difluoroazadienes provided 1-fluoroalkyl-3-fluoroisoquinolines.

Language: Английский

Citations

2
Cascade [3 + 2]/[4 + 2] Cycloaddition of Enaminones with Vinylene Carbonate for the Synthesis of Functionalized Pyrrolo[2,1-a]isoquinoline Derivatives DOI
Jianbo Ma,

Qing-Sheng Zhao,

Yiyong Yin

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9752 - 9758

Published: Nov. 6, 2024

We developed a protocol for the synthesis of functionalized pyrrolo[2,1-a]isoquinoline derivatives (PIQDs) 3 from enaminones 1 using vinylene carbonate 2. This strategy involved [3 + 2] and [4 cycloadditions via heating mixture substrates with 2 DCE at 60 °C, catalyzed by [Cp*RhCl2]2 oxidized Cu(OAc)2 AgSbF6 promoted NaOAc. As we increased reaction temperature to 110 °C under same conditions, synthesized PIQDs 4 through sequential C–H activation, alkene insertion, migratory C–N reductive elimination, β-O finally dehydration. result, series 3–4 were generated forming four bonds (2 C–C bonds) in single step. realizes linear molecules potential biological activity, specifically natural-like heterocycles (3–4). It expands application as C2 synthon construction pyrrole isoquinoline skeletons combinatorial parallel syntheses one-pot reactions.

Language: Английский

Citations

1
Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis DOI
Li Cai,

Pengfei Xiong,

Tao Li

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 271, P. 116417 - 116417

Published: April 16, 2024

Language: Английский

Citations

0