International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130785 - 130785
Published: March 11, 2024
Language: Английский
Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(6), P. 1669 - 1684
Published: Sept. 29, 2022
Language: Английский
Citations
76
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)
Published: Feb. 13, 2023
Abstract Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild‐temperature PTT is a more promising antitumor strategy with much lower phototoxicity neighboring normal tissues. However, the therapeutic efficacy of always restricted by thermoresistance cancer cells. To address this issue, supramolecular drug nanocarrier fabricated co‐deliver nitric oxide (NO) and agent DCTBT NIR‐II aggregation‐induced emission (AIE) characteristic for PTT. NO can be effectively released from nanocarriers in intracellular reductive environment capable simultaneously producing reactive oxygen species (ROS) upon 808 nm laser irradiation. The generated ROS further react produce peroxynitrite (ONOOˉ) bearing strong oxidization nitration capability. ONOOˉ inhibit expression heat shock proteins (HSP) reduce cells, necessary achieve excellent DCTBT‐based at mild temperature (<50 °C). performance ONOOˉ‐potentiated validated on subcutaneous orthotopic hepatocellular carcinoma (HCC) models. This research puts forward an innovative overcome PTT, provides new inspirations explore ONOOˉ‐sensitized tumor strategies.
Language: Английский
Citations
69
Biomaterials, Journal Year: 2023, Volume and Issue: 297, P. 122109 - 122109
Published: April 4, 2023
Language: Английский
Citations
51
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)
Published: May 1, 2024
Abstract The precision treatment of tumors with minimal side effects is associated improved human health and quality life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, effects. Carbon dots (CDs) are considered promising reagents because their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric photothermal conversion properties, outstanding biocompatibility. This review summarizes advancements photo‐responsive CDs for photodynamic the emerging photocatalytic tumors. Finally, article discusses main challenges development oncology therapeutics strategies overcome these challenges.
Language: Английский
Citations
50
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(42)
Published: June 24, 2023
Abstract Induction of immunogenic cell death (ICD) represents a robust therapeutic strategy for cancer treatment. However, only few ICD inducers are currently available and many them take effect based on traditional endoplasmic reticulum (ER) stress rather than mitochondrial stress. Besides, mitochondrion is closely related to ER drug delivery via targeting usually shows higher efficiency cytotoxicity that targeting, which inspires explore the cells through Herein, mito‐missile can realize not mitochondria‐targeted photodynamic therapy (PDT)/mild‐temperature photothermal (MTPTT) but also ICD‐induced immunotherapy constructed. The (termed DIH) prepared by coating dc‐IR825 (a mitochondrion‐targeting cyanine dye)‐loaded polyamidoamine dendrimer with hyaluronic acid. precisely target mitochondria produce reactive oxygen species (ROS) mild heat upon near‐infrared (NIR) light irradiation, inducing damage stress‐caused enhanced ICD. By combining PDT, MTPTT, immunotherapy, DIH efficiently inhibit tumor growth even eradicate tumors. This study develops dendrimer‐based nanoplatform realizing mitochondrion‐acting PDT/MTPTT as well stress‐induced potentiated ICD, may provide guideline designing effective in future.
Language: Английский
Citations
46
Journal of Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 999, P. 122819 - 122819
Published: July 20, 2023
Language: Английский
Citations
42
Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441
Published: March 22, 2024
Language: Английский
Citations
28
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 219 - 238
Published: Jan. 1, 2024
In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally.Photothermal therapy (PTT) is one novel ways treat and abolish cancer.PTT significantly impacts cancer theranostics compared other therapies like surgery, chemotherapy, radiotherapy due its remarkable binding capability tumor sites lower invasiveness into normal healthy tissues.PTT relies on photothermal agents (PTAs), which generate heat by absorbing near-infrared (NIR) light destroying cells.Several PTT remain longer in reticuloendothelial system (RES) induce toxicity, restricting their use biomedical field.To overcome this problem, usage biodegradable nano-photothermal required.This review has discussed mechanism action different types bio-nanomaterials used for PTT.We also focussed combinatorial effects with effect human health.The role LED lights mild hypothermia been briefly review.
Language: Английский
Citations
18
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113770 - 113770
Published: Feb. 1, 2024
Language: Английский
Citations
17
Biomaterials, Journal Year: 2022, Volume and Issue: 292, P. 121917 - 121917
Published: Nov. 24, 2022
Language: Английский
Citations
69