Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
14, P. 100288 - 100288
Published: March 1, 2022
Therapeutic
approaches
of
combining
conventional
photodynamic
therapy
(PDT)
with
other
adjuvant
treatments
to
sensitize
PDT
represent
an
appealing
strategy.
Herein,
a
novel
synergetic
"nanobomb"
strategy
based
on
glutathione
(GSH)-responsive
biodegradation
was
proposed
effectively
destroy
tumors
expeditiously
and
accurately.
This
rationally
constructed
via
the
simultaneous
encapsulation
methylene
blue
(MB)
l-arginine
(L-Arg)
into
polyethylene
glycol
(PEG)
modified
mesoporous
organosilicon
nanoparticles
(MON).
The
resulting
L-Arg/MB@MP
initially
exhibited
prolonged
blood
circulation,
improved
bioavailability,
enhanced
tumor
accumulation
in
mice
after
tail
vein
injection
according
pharmacokinetic
investigations,
before
were
entirely
excreted.
Under
laser
irradiation,
produced
remarkable
reactive
oxygen
species
(ROS)
directly
for
therapy,
while
portion
ROS
may
oxidize
L-Arg
generate
nitric
oxide
(NO)
not
only
gas
(GT)
but
also
serve
as
biological
messenger
regulate
vasodilation
alleviate
hypoxia.
Subsequently,
rapidly
released
NO
further
oxidized
nitrogen
species,
which
together
promote
immunogenic
cell
death
by
inducing
G2/M
cell-cycle
arrest
apoptosis
cancer
cells,
eventually
anti-tumor
immune
responses.
Moreover,
GSH
depletion
tissues
induced
can
cooperate
GT
amplify
therapeutic
effect
PDT.
These
results
demonstrate
that
this
provides
new
ideas
clinical
translation
treat
patients
terms
synergistic
PDT-GT
nanotherapy
hypoxic-solid
tumors.
Small,
Journal Year:
2022,
Volume and Issue:
18(40)
Published: Sept. 7, 2022
Abstract
Acute
lung
injury
(ALI)/acute
respiratory
distress
syndrome
(ARDS)
is
a
common
critical
that
currently
has
no
effective
therapeutic
interventions.
Pulmonary
macrophages
play
principal
role
in
the
initiation
and
progression
of
overwhelming
inflammation
ALI/ARDS.
Here,
type
fluorous‐tagged
bioactive
peptide
nanoparticle
termed
CFF13F
developed,
which
can
be
efficiently
internalized
by
suppress
excessive
expression
cytokines
overproduction
reactive
oxygen
species
(ROS)
triggered
lipopolysaccharide
(LPS).
The
cytoprotective
effect
may
attributed
to
lysosomal‐stabilization
property
regulation
antioxidative
system.
Moreover,
intratracheal
pretreatment
with
effectively
reduce
local
systematic
inflammation,
ameliorate
pulmonary
damage
an
LPS‐induced
ALI
murine
model.
efficacy
affected
administration
routes,
injection
found
optimal
choice
for
treatment,
preferred
biodistribution
profiles.
present
study
provides
solid
evidence
potent
immunomodulatory
bioactivity
nanoparticles
vitro
vivo,
sheds
light
on
development
novel
efficient
nanodrugs
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100834 - 100834
Published: Oct. 20, 2023
Achieving
precision
treatment
in
bone
tissue
engineering
(BTE)
remains
a
challenge.
Photothermal
therapy
(PTT),
as
form
of
therapy,
has
been
extensively
investigated
for
its
safety
and
efficacy.
It
demonstrated
significant
potential
the
orthopedic
diseases
such
tumors,
postoperative
infections
osteoarthritis.
However,
high
temperatures
associated
with
PTT
can
lead
to
certain
limitations
drawbacks.
In
recent
years,
researchers
have
explored
use
biomaterials
mild
photothermal
(MPT),
which
offers
promising
approach
addressing
these
limitations.
This
review
provides
comprehensive
overview
mechanisms
underlying
MPT
presents
compilation
agents
their
utilization
strategies
repair.
Additionally,
paper
discusses
future
prospects
MPT-assisted
regeneration,
aiming
provide
insights
recommendations
optimizing
material
design
this
field.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 15, 2023
Abstract
Phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
great
promise
in
the
treatment
of
cancer.
However,
there
are
many
obstacles
that
can
restrict
therapeutic
efficacy
phototherapy.
The
hypoxic
tumor
microenvironment
production
reactive
oxygen
species
(ROS)
PDT.
As
for
PTT,
thermotolerance
cancer
cells
may
lead
to
ineffective
PTT.
In
this
study,
IR780
glycolysis
inhibitor
lonidamine
(LND)-encapsulated
liposomes
prepared
hepatocellular
carcinoma.
be
used
as
a
photosensitizer
agent
simultaneous
PDT
PTT
after
being
irradiated
with
808
nm
laser.
LND
reduce
consumption
by
inhibiting
glycolysis,
which
will
relieve
hypoxia
produce
more
ROS
On
other
hand,
energy
supply
blocked
LND-induced
inhibition,
inhibit
heat
shock
proteins
(HSPs),
cells,
finally
enhance
enhanced
is
studied
measuring
intracellular
HSPs,
ATP
level,
mitochondrial
membrane
potential.
antitumor
effect
co-loaded
extensively
investigated
vitro
vivo
experiments.
This
research
provides
an
innovative
strategy
simultaneously
promising
future
creative
approaches
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
