Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Intervertebral
disc
degeneration
(IVDD)
is
characterized
by
fibrosis
of
nucleus
pulposus
(NP)
cells
and
accelerated
surrounding
extracellular
matrix
catabolism.
Bioactive
hydrogels
have
shown
significant
potential
in
regulating
cellular
functions
tissue
homeostasis.
In
this
work,
a
dynamic
hydrogel
(HA-NCSN/Cu)
designed
via
the
reductive
chelation
hyaluronic
acid
grafted
with
thiourea
(HA-NCSN)
Cu
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 5, 2024
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 8, 2024
Abstract
The
repair
and
reconstruction
of
large‐scale
bone
defects
face
enormous
challenges
because
the
failure
to
reconstruct
osteo‐vascularization
network.
Herein,
a
near‐infrared
(NIR)
light‐responsive
hydrogel
system
is
reported
achieve
programmed
tissue
regeneration
through
synergetic
effects
on‐demand
drug
delivery
mild
heat
stimulation.
spatiotemporal
(HG/MPa)
composed
polydopamine‐coated
Ti
3
C
2
T
x
MXene
(MP)
nanosheets
decorated
with
acidic
fibroblast
growth
factor
(aFGF,
potent
angiogenic
drug)
hydroxypropyl
chitosan/gelatin
(HG)
developed
orchestrate
network
boost
regeneration.
Upon
exposure
NIR
light
irradiation,
engineered
HG/MPa
can
initial
complete
release
aFGF
induce
rapid
angiogenesis
provide
sufficient
blood
supply,
maximizing
its
biofunction
in
defect
area.
This
integrated
demonstrated
good
therapeutic
efficacy
promoting
cell
adhesion,
proliferation,
migration,
angiogenesis,
osteogenic
differentiation
periodic
irradiation.
In
vivo,
animal
experiments
further
revealed
that
spatiotemporalized
platform
synergized
photothermal
treatment
significantly
accelerated
critical‐sized
healing
by
increasing
density,
recruiting
endogenous
stem
cells,
facilitating
production
osteogenesis/angiogenesis‐related
factors.
Overall,
smart‐responsive
could
enhance
Biomaterials,
Journal Year:
2024,
Volume and Issue:
312, P. 122724 - 122724
Published: July 30, 2024
The
residual
bone
tumor
and
defects
which
is
caused
by
surgical
therapy
of
a
major
important
problem
in
clinicals.
And
the
sequential
treatment
for
irradiating
repairing
has
wildly
prospects.
In
this
study,
we
developed
general
modification
strategy
gallic
acid
(GA)-assisted
coordination
chemistry
to
prepare
black
calcium-based
materials,
combines
photothermal
defects.
GA
endows
materials
remarkable
properties.
Under
near-infrared
(NIR)
irradiation
with
different
power
densities,
GA-modified
matrix
(GBM)
did
not
merely
display
an
excellent
performance
eliminating
high
temperature,
but
showed
facile
effect
mild-heat
stimulation
accelerate
regeneration.
GBM
can
efficiently
regulate
microenvironments
regeneration
spatial-temporal
manner,
including
inflammation/immune
response,
vascularization
osteogenic
differentiation.
Meanwhile,
integrin/PI3K/Akt
signaling
pathway
marrow
mesenchymal
stem
cells
(BMSCs)
was
revealed
be
involved
osteogenesis
induced
stimulation.
outcome
study
only
provides
serial
new
multifunctional
biomaterials,
also
demonstrates
designing
novel
blacked
biomaterials
great
potential
clinical
use.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(25), P. 32058 - 32077
Published: June 14, 2024
The
development
of
growth
factor-free
biomaterials
for
bone
tissue
regeneration
with
anti-infection
and
anti-inflammatory
activities
remains
challenging.
Black
phosphorus
nanosheets
(BPNs),
distinctive
attributes,
including
photothermal
conversion
calcium
ion
chelation,
offer
potential
use
in
engineering
infection
prevention.
However,
BPNs
are
prone
to
oxidation
degradation
aqueous
environments,
methods
stabilize
long-term
repair
remain
insufficient.
Herein,
zeolitic
imidazolate
framework-8
(ZIF-8)
was
used
via
situ
crystallization
onto
the
surface
(BP@ZIF-8
nanocomposite).
A
novel
injectable
dual-component
hydrogel
comprising
gelatin
methacryloyl
(GelMA)
methacrylate-modified
hyaluronic
acid
(HAMA)
as
a
BP@ZIF-8
nanocomposite
carrier
(GelMA/HAMA/BP@ZIF-8).
could
effectively
protect
internal
from
enhance
performance
both
vitro
vivo
settings.
GelMA/HAMA/BP@ZIF-8
exhibited
outstanding
conversion,
mechanical
strength,
biodegradability,
well
excellent
antibacterial
activity
against
Staphylococcus
aureus
Escherichia
coli
an
rat
model.
also
provided
microenvironment
conducive
osteogenic
differentiation,
promoting
transformation
M2
macrophages
inhibiting
inflammatory
responses.
Furthermore,
promoted
had
synergistic
effect
near-infrared
irradiation
skull-defect
Transcriptome
sequencing
analysis
revealed
that
PI3K-AKT-
calcium-signaling
pathways
may
be
involved
differentiation
induced
by
GH-BZ
hydrogel.
This
study
presents
innovative,
multifaceted
solution
challenges
effects,
providing
insights
into
design
smart
dual
therapeutic
capabilities.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 25, 2024
Hydrogels
are
well-suited
for
biomedical
applications
due
to
their
numerous
advantages,
such
as
excellent
bioactivity,
versatile
physical
and
chemical
properties,
effective
drug
delivery
capabilities.
Recently,
hydrogel
coatings
have
developed
functionalize
bone
implants
which
biologically
inert
cannot
withstand
the
complex
tissue
repair
microenvironment.
These
shown
promise
in
addressing
unique
pressing
medical
needs.
This
review
begins
with
major
functionalized
performance
interfacial
bonding
strategy
of
coatings,
a
focus
on
novel
external
field
response
properties
hydrogel.
Recent
advances
fabrication
strategies
use
treatment
pathologic
regeneration
highlighted.
Finally,
challenges
emerging
trends
evolution
application
physiological
environment-responsive
electric
field-responsive
discussed.
