Talanta, Journal Year: 2024, Volume and Issue: 276, P. 126270 - 126270
Published: May 16, 2024
Language: Английский
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 124 - 146
Published: Oct. 4, 2023
Due to its multiple features, including the ability orchestrate remote communication between different tissues, exosomes are extracellular vesicles arousing highest interest in scientific community. Their size, established as an average of 30-150 nm, allows them be easily uptaken by most cells. According type cells-derived exosomes, they may carry specific biomolecular cargoes used reprogram cells interacting with. In certain circumstances, stimulate immune response facilitating or amplifying release foreign antigens-killing cells, inflammatory factors, antibodies (immune activation). Meanwhile, other cases, efficiently malignant elements such cancer mislead recognition mechanism, carrying and transferring their cancerous distant healthy thus contributing antigenic invasion suppression). Exosome dichotomic patterns upon system regulation present broad advantages immunotherapy. Its perfect comprehension, from early biogenesis interaction with recipient will promote a significant enhancement immunotherapy employing molecular biology, nanomedicine, nanotechnology.
Language: Английский
Citations
43
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 121 - 121
Published: Jan. 16, 2025
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made effective drug design. Drug targeting aims ensure that acts only pathological area; it defined as ability accumulate selectively quantitatively target tissue or organ, regardless of chemical structure active substance method administration. With targeting, conventional, biotechnological gene-derived drugs body’s organs, tissues, cells can be transported specific regions. These systems serve carriers regulate timing release. Despite having many advantageous features, these have limitations thoroughly treating complex diseases such cancer. Therefore, combining with nanoparticle technologies imperative treat cancer at both local systemic levels effectively. The nanocarrier-based delivery involves encapsulating target-specific molecules into polymeric vesicular systems. Various (DDS) were investigated discussed this review article. first part passive systems, hydrogels, thermoplastics, microdevices transdermal-based second carrier nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles smart nanogels). third part, advantages discussed, finally, market research commercial used nanotechnological approaches was included.
Language: Английский
Citations
3
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(10), P. 4105 - 4126
Published: Nov. 30, 2022
Messenger RNA (mRNA) is the template for protein biosynthesis and emerging as an essential active molecule to combat various diseases, including viral infection cancer. Especially, mRNA-based vaccines, a new type of vaccine, have played leading role in fighting against current global pandemic COVID-19. However, inherent drawbacks, large size, negative charge, instability, hinder its use therapeutic agent. Lipid carriers are distinguishable promising vehicles mRNA delivery, owning capacity encapsulate deliver negatively charged drugs targeted tissues release cargoes at desired time. Here, we first summarized structure properties different lipid carriers, such liposomes, liposome-like nanoparticles, solid lipid-polymer hybrid nanoemulsions, exosomes lipoprotein particles, their applications delivering mRNA. Then, development lipid-based formulations vaccine delivery systems was discussed highlighted. Recent advancements COVID-19 were emphasized. Finally, described our future vision perspectives this field.
Language: Английский
Citations
67
International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 4861 - 4877
Published: Oct. 1, 2022
Abstract: Bioavailability is an eternal topic that cannot be circumvented by peroral drug delivery. Adequate blood exposure after oral administration a prerequisite for effective treatment. Nanovesicles as pleiotropic vehicles can solubilize, encapsulate, stabilize active ingredient and promote the payload absorption via various mechanisms. Vesicular systems with nanoscale size, such liposomes, niosomes polymersomes, provide versatile platform delivery of drugs distinct nature. The amphiphilicity vesicles in structure allows hydrophilic lipophilic molecule(s) either or both to loaded, being encapsulated aqueous cavity inner core, respectively. Depending on high transport efficiency based their structural flexibility, gastrointestinal stability, biocompatibility, and/or intestinal epithelial affinity, nanovesicles markedly augment bioavailability poorly absorbed drugs. (VDDSs) demonstrate lot preferences are becoming more prominent late years biomedical applications. Equally, these potentiate drug's therapeutic index ameliorating absorption. This review devotes comment VDDSs special emphasis classification nanovesicles, preparative processes, mechanisms, vivo fate, design rationale were expounded. Knowledge vesicles-mediated enhancement has been properly provided. It concluded many merits will step into energetic arena Keywords: vesicles, delivery, bioavailability, niosomes, exosomes
Language: Английский
Citations
43
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.
Language: Английский
Citations
25
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 9, 2024
Triple-negative breast cancer (TNBC) is the most malignant cancer, with high rates of relapse and metastasis. Because nonspecific targeting chemotherapy insurmountable aggressiveness, TNBC therapy lacks an effective strategy. Exosomes have been reported as efficient drug delivery system (DDS). CD82 a tumor metastasis inhibitory molecule that enriched in exosomes. Aptamer AS1411 specifically targets cells due to its expression nucleolin. We generated "triple-punch" cell membrane-derived exosome-mimetic nanovesicle integrated overexpression, conjugation, doxorubicin (DOX) delivery. enrichment effectively inhibits migration cells. conjugation DOX loading proliferation induces apoptosis Our results demonstrate nanovesicles may facilitate therapeutics.
Language: Английский
Citations
16
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 26, 2024
Abstract Tissue regeneration technology has been rapidly developed and widely applied in tissue engineering repair. Compared with traditional approaches like surgical treatment, the rising gene therapy is able to have a durable effect on regeneration, such as impaired bone articular cartilage repair cancer-resected Gene can also facilitate production of situ therapeutic factors, thus minimizing diffusion or loss complexes enabling spatiotemporally controlled release products for regeneration. Among different delivery vectors supportive gene-activated matrices, advanced gene/drug nanocarriers attract exceptional attraction due their tunable physiochemical properties, well excellent adaptive performance bone, cartilage, blood vessel, nerve This paper reviews recent advances nonviral-mediated systems an emphasis important role
Language: Английский
Citations
16
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 83 - 83
Published: Jan. 8, 2024
In this study, we evaluated IL-15 stimulated natural killer cell-derived EVs (NK-EVs) as therapeutic agents in vitro and vivo Osimertinib-resistant lung cancer (H1975R) with EGFR mutations (L858R) combination carboplatin (CBP). NK-EVs were isolated by ultracentrifugation characterized nanoparticle tracking analysis, atomic force microscopy imaging revealed vesicles a spherical form sizes meeting the criteria of exosomal EVs. Further, Western blot studies demonstrated presence regular EV markers along specific NK (perforin granzyme). also proteomic which that had proteins for cell-mediated cytotoxicity (Granzyme B) T cell activation plastin-2). Gene oncology analysis showed these differentially expressed are involved programmed death positive regulation death. cytotoxic to H1975R cells 2D 3D cultures. CBP’s IC50 was reduced approximately cultures when combined NK-EVs. The then CBP administered i.p. route tumor xenografts, significant reduction volume observed. Our findings show first time target PD-L1/PD-1 immunological checkpoint induce apoptosis anti-inflammatory response downregulation SOD2, PARP, BCL2, SET, NF-κB, TGF-ß. ability isolate functional on large scale use them platinum-based drugs may lead new clinical applications. results present study suggest possibility NK-cell-derived viable immunochemotherapeutic strategy resistant cancers.
Language: Английский
Citations
14
Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3065 - 3065
Published: Sept. 29, 2022
Cell type-specific drug delivery is a straightforward strategy to achieve targeted cancer therapy and reduce side effects. Hyaluronic acid (HA), an U.S. Food Drug Administration (FDA)-approved biocompatible carbohydrate polymer, has been extensively employed as targeting ligand for system due its natural ability bind tumor cells overexpressing cluster of differentiation 44 (CD44) receptors. Here, we report the preparation antitumor efficacy HA-coated bovine milk exosomes (HA-mExo) tumor-specific microRNA-204-5p mimics (miR-204). The exosome-based formulation was prepared with miR-204 encapsulated inside lumen HA displayed outside membrane. resultant HA-mExo-miR204 able specifically target CD44-positive cells, concomitant increase in intracellular uptake miR-204. Compared uncoated mExo-miR204 formulation, showed significantly increased both vitro vivo. Importantly, excellent biocompatibility did not cause significant systemic toxicity. Given that are low-cost highly accessible biogenic materials broad biomedical applications, HA-decorated can be proven practical RNA drugs therapy.
Language: Английский
Citations
33
Chemical Communications, Journal Year: 2023, Volume and Issue: 59(44), P. 6609 - 6626
Published: Jan. 1, 2023
We provide comprehensive highlights of the state-of-the-art studies on fluorescent labelling EVs, covering various strategies, biomedical application in vitro , and study EV biology vivo based bioimaging tools.
Language: Английский
Citations
18