Talanta, Journal Year: 2024, Volume and Issue: 276, P. 126270 - 126270
Published: May 16, 2024
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4717 - 4737
Published: July 27, 2024
Over the past decade, research has increasingly identified unique dysregulations in lipid metabolism within tumor microenvironment (TME). Lipids, diverse biomolecules, not only constitute biological membranes but also function as signaling molecules and energy sources. Enhanced synthesis or uptake of lipids TME significantly promotes tumorigenesis proliferation. Moreover, secreted into influence tumor-resident immune cells (TRICs), thereby aiding survival against chemotherapy immunotherapy. This review aims to highlight recent advancements understanding both TRICs, with a particular emphasis on exogenous endogenous
Language: Английский
Citations
7
ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10113 - 10128
Published: May 25, 2023
The extracellular matrix (ECM) is a major driver of fibrotic diseases and forms dense fibrous barrier that impedes nanodrug delivery. Because hyperthermia causes destruction ECM components, we developed nanoparticle preparation to induce fibrosis-specific biological (designated as GPQ-EL-DNP) improve pro-apoptotic therapy against based on remodeling the microenvironment. GPQ-EL-DNP metalloproteinase (MMP)-9-responsive peptide, (GPQ)-modified hybrid containing fibroblast-derived exosomes liposomes (GPQ-EL) loaded with mitochondrial uncoupling agent, 2,4-dinitrophenol (DNP). can specifically accumulate release DNP in focus, inducing collagen denaturation through hyperthermia. was able remodel microenvironment, decrease stiffness, suppress fibroblast activation, which further enhanced delivery fibroblasts sensitized simvastatin-induced apoptosis. Therefore, simvastatin-loaded achieved an improved therapeutic effect multiple types murine fibrosis. Importantly, did not systemic toxicity host. for be used potential strategy enhance diseases.
Language: Английский
Citations
15
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 23, 2023
Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility near infrared (NIR) bio-imaging/theranostics. However, reports on CR PTT are scarce most likely due the short of efficacious delivery strategies achieve specific accumulation diseased tissues induce PTT. Extracellular vesicles (EVs) multifunctional nanoparticle systems that function as safe platform disease theragnostics, which provide benefits extensive biomedical applications. Here, we developed a novel system molecules based dye exerts activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent performance, good biological compatibility superb active tumor-targeting capability. can not only visualize feature tumors intrinsic property photoacoustic imaging (PAI) agent, but also effectively retard tumor growth under laser irradiation perform It is expected engineered EVs will become vehicle small organic agents (SOPTAs) future clinical
Language: Английский
Citations
15
Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(22), P. 7247 - 7267
Published: Jan. 1, 2023
Exosomes are increasingly recognized as important effector molecules that regulate intercellular signaling pathways.
Language: Английский
Citations
12
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4161 - 4183
Published: Jan. 1, 2024
Extracellular vesicles (EVs) are enclosed by a nanoscale phospholipid bilayer membrane and typically range in size from 30 to 200 nm.They contain high concentration of specific proteins, nucleic acids, lipids, reflecting but not identical the composition parent cell.The inherent characteristics variety EVs give them extensive unique advantages field cancer identification treatment.Recently, have been recognized as potential tumor markers for detection cancer.Aptamers, which molecules single-stranded DNA or RNA, demonstrate remarkable specificity affinity their targets adopting distinct tertiary structures.Aptamers offer various over protein counterparts, such reduced immunogenicity, ability convenient large-scale synthesis, straightforward chemical modification.In this review, we summarized biogenesis, sample collection, isolation, storage characterization, finally provided comprehensive survey analysis techniques that based on aptamers.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154653 - 154653
Published: Aug. 8, 2024
Language: Английский
Citations
4
Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance effectiveness of cancer treatment. Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cell‐derived small extracellular vesicles (CsEVs) are emerging as promising treatment due to their inherent properties such low immunogenicity natural targeting capabilities cells. However, a comprehensive comparison advantages, disadvantages, similarities these two platforms is lacking. This review summarizes natural, engineered, hybrid forms CCM‐NPs CsEVs‐based with focus on platforms, considering key aspects including preparation methods, encapsulation strategies, pathways, immune evasion, ability, potential clinical applications. By understanding strengths weaknesses each approach, aim pave next‐generation nanoscale contribute development more effective personalized therapies.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 24, 2025
The effective treatment of Alzheimer's disease (AD) is challenging because its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microglia-related neuroinflammation has recently attracted increasing attention a possible cause AD become novel therapeutic target. Therefore, overcoming BBB targeted anti-inflammatory agents to microglia seem be practical strategies for treating AD. A large proportion natural active extracts possess exceptional immunomodulating capabilities. In this study, cooperative berberine (Ber) palmatine (Pal) by transferrin-decorated extracellular vesicles (Tf-hEVs-Ber/Pal), which can cross precisely target microglia, was performed. This nanosystem effectively cleared amyloid β-protein (Aβ) aggregates, significantly regulated neuroinflammatory environment both in vitro vivo markedly altered behavior improved cognitive learning abilities model mice. efficacy microglia-targeting combined approach demonstrated, broadens potential application Chinese herbal ingredients.
Language: Английский
Citations
0
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Antibody therapy has become a mature cancer treatment strategy, but only one antibody drug, bevacizumab (BEV) been approved to treat glioblastoma (GBM). The natural blood-brain barrier (BBB) significantly limits the penetration of therapeutic antibodies into brain. In this study, an delivery platform based on exosomes (EXOs) developed, which can cross BBB and effectively enter brain tissue deliver BEV for safe effective GBM therapy. vitro experiments have shown that EXO-BEV could efficiently penetrate inhibit migration endothelial cells. Biodistribution studies in vivo revealed EXO serves as carrier transporting higher concentration across Furthermore, antiglioma illustrated introduction improve degeneration pathological tissues, increase apoptosis tumor cells, extend survival time model animals. All results suggested BBB, thereby enhancing cells mitigating angiogenesis GBM. conclusion, innovative emerges highly promising strategy clinical other neurological disorders.
Language: Английский
Citations
3
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(11)
Published: Aug. 24, 2024
Abstract Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis treatment tumors. Despite potential clinical benefits animal‐derived extracellular (AEVs), their large‐scale production remains sluggish due exorbitant cost cell culture, challenging quality control measures, limited capabilities. This constraint significantly hinders widespread application. Plant‐derived (PEVs) share similar functionalities with AEVs, yet they hold several advantages including wide variety source materials, cost‐effectiveness, ease preparation, enhanced safety, more stable physicochemical notable efficacy. These merits position PEVs promising contenders broad biomedical sector. review will elucidate PEVs, delineating therapeutic mechanisms cancer treatment, explore prospective applications engineered targeted nano‐system drugs, microRNAs, small interfering RNAs, beyond. The aim is heighten researchers’ focus on expedite progression from fundamental research transformation groundbreaking discoveries.
Language: Английский
Citations
2