Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 136024 - 136024
Published: Dec. 1, 2024
Language: Английский
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 13, 2024
Exosomes, extracellular vesicles secreted by cells, have garnered significant attention in recent years for their remarkable therapeutic potential. These nanoscale carriers can be harnessed the targeted delivery of agents, such as pharmaceuticals, proteins, and nucleic acids, across biological barriers. This versatile attribute exosomes is a promising modality precision medicine applications, notably realm cancer therapy. However, despite substantial potential, still confront challenges tied to standardization scalability that impede practice clinical applications. Moreover, heterogeneity isolation methodologies limited cargo loading mechanisms pose obstacles ensuring consistent outcomes, thereby constraining utility. In contrast, exhibit distinct advantage diagnosis, they harbor specific signatures reflective tumor's genetic proteomic profile. characteristic endows them with potential serve valuable liquid biopsies non-invasive real-time monitoring, making possible early detection development personalized treatment strategies. this review, we provide an extensive evaluation advancements exosome research, critically examining advantages limitations context therapy diagnosis. Furthermore, present curated overview most technological innovations utilizing exosomes, focus on enhancing efficacy detection.
Language: Английский
Citations
30
Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.
Language: Английский
Citations
20
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: Feb. 11, 2025
Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3657 - 3675
Published: April 1, 2024
Abstract: Exosomes are extracellular vesicles that originate from various cells and mediate intercellular communication, altering the behavior or fate of recipient cells. They carry diverse macromolecules, such as lipids, proteins, carbohydrates, nucleic acids. Environmental stressors can change exosomal contents many cells, making them useful for diagnosing chronic disorders, especially neurodegenerative, cardiovascular, cancerous, diabetic diseases. Moreover, exosomes be engineered therapeutic agents to modulate disease processes. State-of-art techniques employed separate including ultracentrifugation, size-exclusion chromatography immunoaffinity. However, modern technologies aqueous two-phase system well microfluidics gaining attention in recent years. The article highlighted composition, biogenesis, implications exosomes, standard novel methods isolating applying biomarkers cargo carriers. Keywords: Exosomes, vesicles, biomarkers, carriers, separation
Language: Английский
Citations
12
Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(8), P. 2165 - 2193
Published: Sept. 28, 2024
Language: Английский
Citations
9
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(14), P. 3480 - 3499
Published: Jan. 1, 2024
This review highlights the advances of functional extracellular nanovesicles in CRISPR delivery, including their cellular entry pathways, functionalization techniques, and challenges strategies pivotal for clinical translation.
Language: Английский
Citations
4
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The schematic demonstrates MSC seeded-Chitosan-Collagen-Fibrinogen-D3(CCF-D3) scaffold with HADF seeded-dextran beads-coculture for vascular sprouting via VEGF-associated pathway and inhibited by 100 μM dexamethasone, exosomal spectra analysis.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100035 - 100035
Published: March 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8641 - 8660
Published: Aug. 1, 2024
Osteosarcoma is the predominant primary malignant bone tumor that poses a significant global health challenge. MicroRNAs (miRNAs) regulate gene expression are associated with osteosarcoma pathogenesis. Thus, miRNAs potential therapeutic targets for osteosarcoma. Nanoparticles, widely used targeted drug delivery, facilitate miRNA-based treatment. Numerous studies have focused on miRNA delivery using nanoparticles to inhibit progress of Polymer-based, lipid-based, inorganic-based and extracellular vesicles were deliver treatment They can be modified enhance loading capabilities. Also, was combined traditional therapies, example chemotherapy, treat Consequently, offers promising avenues osteosarcoma, providing renewed hope patients. This review emphasizes utilizing in treatment, then introduced summarized detail. And it also discusses prospects clinical applications.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 167 - 201
Published: Nov. 29, 2024
Language: Английский
Citations
0