Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A photocatalyzed radical-umpolung strategy is developed to synthesize trifluoromethylated α-unnatural amino acids and amines. This method involves the migration of an N-centred radical through aromatic framework construct C–CF 3 bond.
Language: Английский
Organic Letters, Journal Year: 2024, Volume and Issue: 26(2), P. 427 - 432
Published: Jan. 8, 2024
A mild approach to the visible-light-mediated bimetal-catalyzed meta-alkylation of arenes has been accomplished. The regioselective is realized by a bimetallic ruthenium–palladium system. Ruthenium acts as catalyst for directing effect and photosensitizer, while cocatalyst palladium behaves generation fluoroalkyl radicals. This reaction not only suitable two-component meta-fluoroalkylation but can also be extended three-component reactions achieve bifunctionalization olefins.
Language: Английский
Citations
8
ACS Catalysis, Journal Year: 2023, Volume and Issue: 13(11), P. 7310 - 7321
Published: May 15, 2023
Anilines are important moieties in organic chemistry, pharmaceuticals, and materials science. Although para-selective functionalization of anilides tertiary anilines is well established, unprotected have posed a challenge. Herein, we report visible-light-mediated Ru(II)-catalyzed para-alkylation anilines. The distinct Ru(II)–aniline complex enabled the reaction to proceed with extremely high efficiency (2 h) under mild conditions. good functional group tolerance allowed late-stage even aggregation-induced emission luminogen labeling natural products drugs. A mechanistic investigation suggests that crucial for both triggering controlling para-selectivity.
Language: Английский
Citations
14
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(12), P. 7007 - 7012
Published: Jan. 1, 2024
An organophotoredox-catalyzed difluoromethylation of aromatic amines was developed for green, environmentally friendly, sustainable, and expedient access to high value-added para -difluoromethylated compounds with excellent regioselectivities.
Language: Английский
Citations
5
Organic Letters, Journal Year: 2024, Volume and Issue: 26(8), P. 1739 - 1744
Published: Feb. 17, 2024
A general catalytic donor for the combination of a photoinduced electron donor–acceptor (EDA) complex and energy transfer was developed. This mild metal-free protocol allows facile access to various Z-alkenes. Mechanism studies revealed that organophotocatalyst, 4-CzIPN, formed distinct three-component EDA with redox-active esters (C6H5O)2P(O)OH trigger photoredox catalysis. The E → Z isomerization achieved via exchange from 4-CzIPN.
Language: Английский
Citations
4
Chemical Communications, Journal Year: 2022, Volume and Issue: 58(93), P. 12900 - 12912
Published: Jan. 1, 2022
Polyfluoroaryl compounds belong to privileged moieties and engender distinct properties in many pharmaceuticals, agrochemicals, materials. In this review, state-of-the-art photocatalytic polyfluoroarylation has been present since 2014.
Language: Английский
Citations
18
Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Abstract Photoredox fluoroalkylation has emerged as a powerful method and have unlocked new possibilities in organic chemistry. In this work, the green‐light‐induced copper‐mediated difluoroalkylation of arylsulfonium salts with different XCF 2 COR reagents is described. The reaction proceeded smoothly at ambient temperature under mild conditions allowed formation variety difluoroalkylated arenes good yields. photocatalyst, visible‐light, Cu(I) salt played synergetic role reduction to respective radical intermediates. This metallophotoredox protocol was applicable late‐stage multifunctionalized bioactive molecules, offering opportunities discovery medicinal agents. transformation showed advantages mildness, simple operation, functional group tolerance, wide range substrates, excellent regioselectivity, which provided an interesting alternative other reactions terms structural diversity, selectivity, availability by application platforms.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(16), P. 12739 - 12745
Published: Jan. 1, 2025
A mild and effective visible-light-induced decarboxylative radical cascade reaction of olefin-containing imidazoles α-fluorinated carboxylic acids, has been developed to afford monofluoromethylated or aryldifluoromethylated polycyclic imidazoles.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 5, 2024
Abstract Catalytic activation of C aryl ‐O bonds is considered as a powerful strategy for the production aromatics from lignin. However, due to high reduction potentials diaryl ether 4‐O‐5 linkage models, their single electron remains daunting challenge. This study presents blue light‐induced bifunctional N‐heterocyclic carbene (NHC)‐catalyzed one‐electron models synthesis trivalent phosphines. The H‐bond between newly devised NHC and ethers responsible success transfer. Furthermore, this approach demonstrates selective unsymmetric ethers, oligomeric phenylene oxide, lignin model.
Language: Английский
Citations
3
Journal of Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 996, P. 122757 - 122757
Published: May 17, 2023
Language: Английский
Citations
6
Science China Materials, Journal Year: 2023, Volume and Issue: 66(12), P. 4689 - 4696
Published: Nov. 17, 2023
Language: Английский
Citations
4