Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1163 - 1176
Published: Dec. 1, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 18, 2024
Abstract Background The complex etiology and pathogenesis underlying Chronic Non-Bacterial Prostatitis (CNP), coupled with the existence of a Blood Prostate Barrier (BPB), contribute to lack specificity poor penetration most drugs. Emodin (EMO), potential natural compound for CNP treatment, exhibits commendable anti-inflammatory, anti-oxidant, anti-fibrosis properties but suffers from same problems as other Methods By exploiting recognition lactoferrin (LF) receptors that target intestinal epithelial cells (NCM-460) prostate (RWPE-1), pathway is established transrectal absorption EMO effectively reach prostate. Additionally, hyaluronic acid (HA) employed, recognizing CD44 which macrophages within inflamed This interaction facilitates intraprostatic delivery EMO, leading its pronounced anti-inflammatory effects. A thermosensitive hydrogel (CS-Gel) prepared chitosan (CS) β-glycerophosphate disodium salt (β-GP) was used rectal drug strong adhesion achieve effective retention sustained slow release. Thus, we developed triple-targeted nanoparticle (NPs)/thermosensitive (Gel) system. In this process, LF, positive charge, utilized load through dialysis, producing LF@EMO-NPs. Subsequently, HA employed encapsulate EMO-loaded LF nanoparticles via electrostatic adsorption, yielding HA/LF@EMO-NPs. Finally, HA/LF@EMO-NPs lyophilized powder added CS-Gel (HA/LF@EMO-NPs Gel). Results Cellular assays indicated NCM-460 RWPE-1 showed high uptake both LF@EMO-NPs HA/LF@EMO-NPs, while Raw 264.7 exhibited substantial For LPS-induced cells, can reduce inflammatory responses by modulating TLR4/NF-κB signaling pathways. Tissue imaging corroborated capacity HA/LF-modified formulations breach BPB, accumulating gland's lumen. Animal experiments administration Gel significantly reduced cytokine expression, oxidative stress levels fibrosis in rats, addition exerting effects inhibiting NF-κB without obvious toxicity. Conclusion NPs/Gel system slow-release shows great treatment CNP. Graphical
Language: Английский
Citations
18
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, challenges inadequate targeting limited biocompatibility persist. In recent years, cell membrane nano-biomimetic have emerged as a focal point research development, due to their exceptional traits, including precise targeting, low toxicity, good biocompatibility. This review outlines categorization advantages bionic nano-delivery systems, provides an introduction preparation methods, assesses applications in treatment, chemotherapy, gene therapy, immunotherapy, photodynamic photothermal combination therapy. Notably, delves into application various identifies opportunities future advancement. Embracing membrane-coated biomimetic nanoparticles presents novel unparalleled avenue personalized tumor
Language: Английский
Citations
18
Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 478, P. 214977 - 214977
Published: Dec. 15, 2022
Language: Английский
Citations
58
Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101005 - 101005
Published: Aug. 21, 2023
Multidrug resistance in pancreatic cancer poses a significant challenge clinical treatment. Bufalin (BA), compound found secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its application. Hence, present study aimed to develop cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) assess potential counter chemoresistance cancer.The toxicity CBAP was evaluated by electrocardiogram, body weight, distress score, nesting behavior mice. In addition, anticarcinoma activity underlying mechanism were investigated both vitro vivo.CBAP significantly mitigated BA-mediated acute enhanced sensitivity several drugs, such as gemcitabine, 5-fluorouracil, FOLFIRINOX. Mechanistically, directly bound nucleotide-binding oligomerization domain containing protein 2 (NOD2) inhibited expression nuclear factor kappa-light-chain-enhancer activated B cells. This inhibits ATP-binding cassette transporters, which are responsible for cells.Our findings indicate that NOD2. Combining with standard-of-care chemotherapeutics represents safe efficient strategy treatment cancer.
Language: Английский
Citations
30
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 279 - 293
Published: Jan. 12, 2023
Language: Английский
Citations
24
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: July 14, 2024
This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.
Language: Английский
Citations
16
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3643 - 3660
Published: April 15, 2024
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify synergistic effects chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL) as inducer immunogenic cell death (ICD) by promoting ER stress autophagy in colorectal cancer (CRC) cells. Subsequently, ER-targeted strategy was posited, involving codelivery CEL with PD-L1 small interfering RNAs (siRNA) using KDEL peptide-modified exosomes derived from milk (KME), enhance outcomes. Our findings demonstrate efficient transportation KME via Golgi-to-ER pathway. Compared their non-targeting counterparts, exhibited a significant augmentation CEL-induced ICD effect. Additionally, it facilitated release danger signaling molecules (DAMPs), thereby stimulating antigen-presenting function dendritic cells infiltration T into tumor. Concurrently, delivery siRNA resulted downregulation both intracellular membrane protein expression, consequently fostering proliferation activity CD8+ Ultimately, formulation enhanced anti-tumor efficacy provoked immune responses against orthotopic tumors vivo. Collectively, robust provides encouraging approach for achieving potent chemoimmunotherapy.
Language: Английский
Citations
11
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(5), P. 413 - 413
Published: Feb. 23, 2024
Recent strides in nanomaterials science have paved the way for creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering integration natural cell membranes into sophisticated nanocarrier architectures, membrane camouflage has emerged as a transformative approach regulated drug delivery, offering benefits minimal immunogenicity coupled with active targeting capabilities. Nevertheless, utility such is curtailed by challenges like suboptimal precision lackluster therapeutic efficacy. Tailored engineering stands at forefront biomedicine, equipping nanoplatforms capacity to conduct more complex operations. This review commences an examination prevailing methodologies engineering, spotlighting strategies direct chemical modification, lipid insertion, hybridization, metabolic glycan labeling, genetic engineering. Following this, evaluation unique attributes various presented, delivering in-depth scrutiny substantial advancements applications driven cutting-edge engineered camouflage. The discourse culminates recapitulating salient influence within nanomaterial prognosticates its seminal role healthcare technologies. It envisaged that insights offered herein will catalyze novel avenues innovation refinement camouflaged nanotechnologies.
Language: Английский
Citations
10
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Nov. 24, 2023
The oral delivery of nano-drug systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core-shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nanospikes (VSN) to simulate viral morphology, and further modified VSN L-alanine (CVSN) enable chiral recognition for functional bionics. By comparing the solid NPs, NPs VSN, demonstrate advantages CVSN on overcoming intestinal sequential barriers in both animals human via multiple biological processes. Subsequently, encapsulate indomethacin (IMC) into nanopores mimic gene package, wherein payloads are isolated bio-environments exist an amorphous form increase their stability solubility, while multi-sited anchor recognize mucosa enhance penetrability ultimately improve adsorption IMC. Encouragingly, also prove versatility as Nano-DDS.
Language: Английский
Citations
22
Nano Letters, Journal Year: 2023, Volume and Issue: 23(16), P. 7758 - 7766
Published: July 11, 2023
The intestinal compartment ensures nutrient absorption and barrier function against pathogens. Despite decades of research on the complexity gut, adaptive potential to physical cues, such as those derived from interaction with particles different shapes, remains less understood. Taking advantage technological versatility silica nanoparticles, spherical, rod-shaped, virus-like materials were synthesized. Morphology-dependent interactions studied differentiated Caco-2/HT29-MTX-E12 cells. Contributions shape, aspect ratio, surface roughness, size evaluated considering influence mucus layer intracellular uptake pathways. Small particle roughness favored highest penetration through but limited cell monolayer efficient internalization. Particles a larger ratio (rod-shaped) seemed privilege paracellular permeation increased cell–cell distances, albeit without hampering integrity. Inhibition clathrin-mediated endocytosis chemical modulation junctions effectively tuned these responses, confirming morphology-specific elicited by bioinspired nanomaterials.
Language: Английский
Citations
16