Augmented the sensitivity of photothermal-ferroptosis therapy in triple-negative breast cancer through mitochondria-targeted nanoreactor

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 733 - 744

Published: Sept. 29, 2024

Language: Английский

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MXene–AuNCs-based electrochemical aptasensor for ultrasensitive detection of neuron-specific enolase in early lung cancer diagnosis

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112732 - 112732

Published: Jan. 1, 2025

Language: Английский

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Advances and applications of G-quadruplex in diagnostics

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112737 - 112737

Published: Jan. 1, 2025

Language: Английский

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H9N2 avian influenza virus diagnostics utilizing specific high-sensitivity enzymatic molecular system termed RPA-based CRISPR-Cas13a

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140474 - 140474

Published: Jan. 1, 2025

Language: Английский

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The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment neurodegenerative diseases characterised by neuron loss or degeneration. This results from complex pathogenesis and limited drug uptake brain due to presence blood‐brain barrier. Nanoparticle‐based delivery systems expected improve utilisation. Polymeric nanoparticles represent promising carriers their unique advantages such as good biodegradability biocompatibility, flexibility surface modification nontoxicity. addition, genetic drugs may stop progression at level even avoid irreversible damage central nervous system. this review, an overview studies on polymer‐based system typical diseases, especially Alzheimer's Parkinson's is described. Meanwhile, applications gene these disorders discussed. And challenges future perspectives development polymeric concluded.

Language: Английский

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Tetrahedral DNA nanostructure based siRNA delivery vehicle for braf gene silencing and MEK-ERK pathway inhibition in the treatment of refractory thyroid cancer

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102694 - 102694

Published: Feb. 28, 2025

Language: Английский

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Hydrogel sensing platforms for monitoring contractility in in vitro cardiac models

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review summarizes current methods for monitoring cardiomyocyte contractility and explores recent advances in hydrogel-based platforms cell contraction forces. Copyright 2023, Springer Nature; 2019 2022, John Wiley Sons.

Language: Английский

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DNA Aptamers with Chemically Locked Ends for Virus Infection Inhibition

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Nucleic acid aptamers, known as chemical antibodies, demonstrate remarkable affinity and specificity for targets. Therefore, aptamers are proposed an alternative to antibody in extensive applications. However, nucleic exhibit poor tolerance degradation by nucleases, which severely hampers their biological Herein, we developed a regulation pattern utilizing small-molecule-mediated terminal manipulation, could prevent the interaction of DNA with exonucleases help persist desired conformation high stability. Diagonal T-T bases were designed ends be chemically cross-linked trioxsalen via photocatalyzed cycloaddition. Aptamers different patterns cross-linking sites synthesized. Experimental investigation molecular dynamics simulations combinedly revealed that efficiency depended on multiple factors: (i) number sequences, (ii) spatial (iii) competitive binding ability compared other base sites. The locked exhibited superior exonuclease resistance, especially both 3'- 5'-cross-linked ends, thus demonstrating great target capability. Notably, application exploration, bound receptor-binding domains SARS-CoV-2, showed performance virus infection inhibition. This work puts forward paradigm develop based manipulation DNA, potentially promoting clinical applications drugs.

Language: Английский

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Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(7), P. 109169 - 109169

Published: Oct. 9, 2023

Language: Английский

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From biogenesis to aptasensors: advancements in analysis for tumor-derived extracellular vesicles research

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4161 - 4183

Published: Jan. 1, 2024

Extracellular vesicles (EVs) are enclosed by a nanoscale phospholipid bilayer membrane and typically range in size from 30 to 200 nm.They contain high concentration of specific proteins, nucleic acids, lipids, reflecting but not identical the composition parent cell.The inherent characteristics variety EVs give them extensive unique advantages field cancer identification treatment.Recently, have been recognized as potential tumor markers for detection cancer.Aptamers, which molecules single-stranded DNA or RNA, demonstrate remarkable specificity affinity their targets adopting distinct tertiary structures.Aptamers offer various over protein counterparts, such reduced immunogenicity, ability convenient large-scale synthesis, straightforward chemical modification.In this review, we summarized biogenesis, sample collection, isolation, storage characterization, finally provided comprehensive survey analysis techniques that based on aptamers.

Language: Английский

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