A multifunctional fluorescent probe for sequential detection of hydrogen sulfide and pH in foodstuffs, living cells and mice
Zu‐Sheng Huang,
No information about this author
Wenxuan Zhang,
No information about this author
Manshan Liang
No information about this author
et al.
Analytica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
1299, P. 342434 - 342434
Published: Feb. 28, 2024
Language: Английский
A single excitation dual emission semi-salamo type multi-functional probe for sensitive pH and Cu2+ detection
Wenting Guo,
No information about this author
Dongzhen Bai,
No information about this author
Yunzhao He
No information about this author
et al.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Journal Year:
2024,
Volume and Issue:
318, P. 124386 - 124386
Published: May 3, 2024
Language: Английский
De Novo Construction of pKa‐Tunable Xanthene Molecules for pH Sensitive Fluorescence Navigation
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Abstract
pH
is
spatiotemporal
variable
dynamically
in
physiological
and
pathological
processes,
the
tiny
changes
can
result
completely
different
processes.
However,
major
drawbacks
of
conventional
pH‐activatable
probes
are
their
large
acid‐base
transition
width
challenge
to
adjust
pKa
suitable
for
various
application.
In
response
these
issues,
a
novel
approach
proposed
realize
sensitive
general
strategy
construct
multicolor
pKa‐tunable
xanthene‐based
platform.
probes,
narrowest
range
just
1
units,
achieved
by
introducing
electron‐rich
pyridine
as
ingenious
proton
catcher.
Especially,
Si‐4Py
owns
near‐infrared
(NIR)
signal
5.56,
which
successfully
used
rapid
high‐contrast
imaging
distal
metastatic
tumors.
This
has
significant
implications
guiding
surgeons
removal
tumors
ultimately
improve
patient
outcomes.
Additional,
sustainably
innovative
this
work
serve
effective
reference
probe
development.
Language: Английский
Next-generation Red Ultra-bright Fluorescent Dyes for Nuclear Imaging and Peripheral Blood Leukocytes Sorting
Chemical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
red
ultra-bright
nuclear-targeted
dye
BPC1
was
developed.
exhibits
ultrahigh
fluorescence
brightness
and
exceptional
cell
permeability,
enabling
the
visualization
of
nucleus
by
substantially
lower
doses
(100
nM)
laser
power.
Language: Английский
Mitochondria–Nucleus Migration Probe for Ultrasensitive Monitoring of mtDNA Damage in Living Cells
Zhen‐Qing Yu,
No information about this author
Wenjing Pan,
No information about this author
Xiao‐Feng Yang
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
97(1), P. 584 - 593
Published: Dec. 31, 2024
Mitochondrial
DNA
(mtDNA)
damage
is
a
prevalent
phenomenon
that
has
been
proven
to
be
implicated
in
wide
spectrum
of
diseases.
However,
the
progressive
attenuation
probe
signals
response
mtDNA
within
living
cells
inherently
limits
sensitivity
and
precision
current
probes
for
detecting
damage.
Herein,
we
employ
an
innovative
organelle
signal
ratio
imaging
approach,
utilizing
mitochondria–nucleus
migration
MCQ,
achieve
unparalleled
cells.
MCQ
exhibited
initial
preferential
binding
mtDNA,
facilitated
by
its
cationic
quinolinium
moiety,
but
migrated
nucleus
upon
This
unique
behavior
not
only
enhanced
spatial
identifiability
also
amplified
detection
significantly
harnessing
intensified
against
attenuated
mitochondrial
signal.
approach
established
positive
correlation
between
damage,
enabling
even
subtle
at
early
stage
apoptosis
with
remarkable
23-fold
enhancement
following
just
5
min
H2O2
induction
cells,
whereas
conventional
methods
relying
solely
on
fading
proved
insufficient.
Furthermore,
MCQ's
ability
monitor
occurrence
achieved
intricate
differentiation
ferroptosis.
By
monitoring
drug-induced
cancer
was
further
conducted
using
evaluate
therapeutic
efficacy
four
anticancer
drugs
very
low
concentrations.
strategy
paves
way
ultrasensitive
holds
immense
promise
damage-associated
Language: Английский