Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

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Ultrasmall CuMn-His Nanozymes with Multienzyme Activity at Neutral pH: Construction of a Colorimetric Sensing Array for Biothiol Detection and Disease Identification

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34538 - 34548

Published: June 28, 2024

Biothiol assays offer vital insights into health assessment and facilitate the early detection of potential issues, thereby enabling timely effective interventions. In this study, we developed ultrasmall CuMn-Histidine (His) nanozymes with multiple enzymatic activities. CuMn-His enhanced peroxidase (POD)-like activity at neutral pH was achieved through hydrogen bonding electrostatic effects. addition, possesses laccase (LAC)-like superoxide dismutase (SOD)-like activities pH. Based on three different enzyme mimetic pH, colorimetric sensing array without changing buffer solution successfully constructed. The used for identification biothiols, glutathione (GSH), cysteine (Cys), homocysteine (Hcy). Subsequently, excellent application results were shown in complex serum cellular level analyses. This study provides an innovative strategy development bimetallic construction arrays.

Language: Английский

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Transition-metal-based nanozymes for biosensing and catalytic tumor therapy

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(27), P. 5933 - 5948

Published: May 23, 2024

Language: Английский

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L‐Arginine‐Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability gut lack of targeting, hindering precise intervention at lesion site. study prepares an L-Arginine-modified selenium nanozyme (Se-CA) for targeted oral treatment UC. Se-CA specifically targets M1-type macrophages sites by binding cationic amino acid transporter protein 2 on surface macrophages. In vitro studies show that scavenges nitrogen (RNS) artificial gastric fluids, inhibits iron death cells. mice model ulcerative colitis, administration is effective through its anti-inflammatory properties, inhibition regulation flora. conclusion, this work provides new insights into

Language: Английский

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Oral Antioxidant-Engineered Probiotics for the Treatment of Radiation-Induced Colitis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Radiation colitis is an inflammatory response induced by damage to colonic tissue from radiation therapy that primarily affects patients undergoing abdominal or pelvic treatments. In this study, we designed a selenium-loaded probiotic (EcN-Se@SA) encapsulated in sodium alginate gel for the oral treatment of colitis. Selenium nanoparticles (Se NPs) exhibit antioxidant, anti-inflammatory, ferroptosis, and repair-promoting properties. To enhance therapeutic efficacy Se NPs radiation-induced colitis, combined with Escherichia coli Nissle 1917 them hydrogel. The resulting EcN-Se@SA formulation not only withstands gastric acid intestinal fluids but also remains colon cecum extended periods. Oral administration attenuates X-ray-induced mice through its antioxidant anti-inflammatory effects, macrophage reprogramming, inhibition ferroptosis histiocytes. This work introduces promising candidate

Language: Английский

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Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.

Language: Английский

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Recent progress in the rational design and applications of nanozymes

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 25 - 38

Published: March 1, 2025

Language: Английский

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Amino acid regulation of peroxidase-like activity of Cu2O nanozyme for detection of tetracycline antibiotics

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский

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Toward high-purity vanadium-based materials: Fundamentals, purifications, and perspectives

Journal of Cleaner Production, Journal Year: 2024, Volume and Issue: unknown, P. 143721 - 143721

Published: Sept. 1, 2024

Language: Английский

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