Deep-red/NIR emitting coumarin derivatives - Synthesis, photophysical properties, and biological applications

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 202, P. 110306 - 110306

Published: April 9, 2022

Language: Английский

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Polymethine dyes for PDT: recent advances and perspectives to drive future applications

Photochemical & Photobiological Sciences, Journal Year: 2022, Volume and Issue: 21(3), P. 397 - 419

Published: Feb. 1, 2022

Abstract It has been proved that the effectiveness of photodynamic therapy (PDT) is closely related to intrinsic features photosensitizer (PS). Over recent years, several efforts have devoted discovery novel and more efficient photosensitizers showing higher efficacy lower side effects. In this context, squaraine cyanine dyes reported potentially overcome drawbacks traditional PSs. fact, squaraines cyanines are characterized by sharp intense absorption bands narrow emission with high extinction coefficients typically in red near-infrared region, good photo thermal stability a strong fluorescent organic solvents. addition, biocompatibility low toxicity make them suitable for biological applications. Despite these interesting features, their chemical instability self-aggregation properties media still limit use PDT. To drawbacks, self-assembly incorporation into smart nanoparticle systems forwarded promising approaches can control physicochemical properties, providing rational solutions limitation free dye administration PDT application. The present review summarizes latest advances application, analyzing different strategies, i.e.the nanoparticles, further enhance photochemical therapeutic potential. vivo assessments limited, thus delaying effective application Graphical abstract

Language: Английский

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Conformationally restricted and ring-fused aza-BODIPYs as promising near infrared absorbing and emitting dyes

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 470, P. 214709 - 214709

Published: July 14, 2022

Language: Английский

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Phototherapy Using a Fluoroquinolone Antibiotic Drug to Suppress Tumor Migration and Proliferation and to Enhance Apoptosis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4917 - 4929

Published: March 11, 2022

In this work, a fluoroquinolone antibiotic drug (sparfloxacin (SP)) was selected as chemotherapy and photosensitizer for combined therapy. A facile chemical process developed to incorporate SP upconversion nanoparticles (UCNPs) into the thermally sensitive amphiphilic polymer polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane). vitro in vivo experiments showed that 60% of molecules can be released from micelles thermal-sensitive polymers using 1 W cm-2 980 nm laser, successfully inhibits cell migration metastasis by inhibiting type II topoisomerases nuclei. Additionally, intracellular metal ions were chelated induce cancer apoptosis decreasing activity superoxide dismutase catalase. particular, produced singlet oxygen (1O2) kill cells, triggered UCNPs when irradiation performed with laser. Overall, retained weak chemotherapeutic effect, achieved enhanced photosensitizer-like effects, able repurpose old drugs elevate therapeutic efficacy against cancer, increase specificity suppressing tumor proliferation, enhance apoptosis.

Language: Английский

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Design, synthesis and functionalization of BODIPY dyes: applications in dye-sensitized solar cells (DSSCs) and photodynamic therapy (PDT)

Journal of Materials Chemistry C, Journal Year: 2023, Volume and Issue: 11(26), P. 8688 - 8723

Published: Jan. 1, 2023

The present review focuses on the design, synthesis, functionalization, and application of BODIPY dyes in dye-sensitized solar cells photodynamic therapy.

Language: Английский

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