Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
22, P. 100765 - 100765
Published: Aug. 14, 2023
Oxidative
stress
induced
by
reactive
oxygen
species
(ROS)
is
promising
treatment
approach
for
pancreatic
ductal
adenocarcinoma
(PDAC),
which
typically
insensitive
to
conventional
chemotherapy.
In
this
study,
BxPC-3
cancer
cell
membrane-coated
upconversion
nanoparticles/ZnxMn1-xS
core-shell
nanoparticles
(abbreviated
as
BUC@ZMS)
were
developed
tumor-targeted
therapy
via
synergistically
oxidative
and
overcoming
glutathione
(GSH)
overexpression.
Using
a
combination
of
photodynamic
(PDT)
chemodynamic
(CDT),
the
BUC@ZMS
able
elicit
death
cells
through
high
production
ROS.
Additionally,
could
deplete
intracellular
GSH
increase
sensitivity
tumor
stress.
The
in
vivo
results
indicated
that
can
accumulate
specifically
locations
suppress
PDAC
without
generating
obvious
toxicity.
Thus,
it
was
determined
as-prepared
would
be
viable
option
solid
malignancies.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(10)
Published: Jan. 11, 2023
Although
zeolitic
imidazolate
framework-8
(ZIF-8)
has
been
applied
in
various
tumor
therapies,
the
intrinsic
immunogenicity
remains
unclear.
Here,
we
initiatively
discover
that
ZIF-8
nanoparticles
(NPs)
can
intrinsically
induce
pyroptosis
by
a
caspase-1/gasdermin
D
(GSDMD)-dependent
pathway.
The
pyroptotic
cell
death
is
accompanied
necrosis
and
immunogenic
(ICD)
simultaneously
for
efficient
situ
immunity
initiation.
Meanwhile,
carbonyl
cyanide
m-chlorophenyl
hydrazone
(CCCP),
mitochondrial
depolarizing
agent,
successfully
loaded
into
NPs
found
to
further
enhance
process.
Collectively,
obtained
Pluronic
F127-modified
CCCP-incorporated
(F127
ZIF-8CCCP
NPs)
activate
antitumor
reprogram
immunosuppressive
microenvironment
(TME),
realizing
high-efficiency
growth
inhibition.
This
work
will
facilitate
biomedicine
applications
of
provide
good
inspiration
pyroptosis-induced
cancer
therapy.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(24)
Published: April 22, 2023
Chronic
nonhealing
diabetic
wounds
are
becoming
increasingly
severe,
with
high
rates
of
mortality
and
disability,
owing
to
the
difficulty
in
wound
healing
caused
by
hyperglycemia,
blocked
angiogenesis,
biofilm
infection,
excessive
oxidative
stress.
A
multicomponent
enzyme-responsive
natural
polymer,
a
hyaluronic
acid
(HA)
microneedle,
embedded
cerium/zinc-based
nanomaterial
(ZCO)
for
treatment
is
reported.
ZCO-HA
can
destroy
oxidation
balance
bacteria,
kill
scavenge
reactive
oxygen
species
(ROS)
alleviate
stress
via
adjustable
release
Zn2+
Ce3+
/4+
.
Additionally,
exhibits
good
anti-inflammatory
activity
through
nuclear
factor
kappa-B
(NF-κB)
pathway,
which
reduces
inflammatory
state
macrophages
promotes
cell
proliferation,
migration,
angiogenesis.
In
vitro
experiments
shows
that
accompanies
mouse
fibroblast
promoting
human
umbilical
vein
endothelial
tube
formation.
vivo
studies
mice
streptozotocin-induced
(STZ)-induced
diabetes
reveal
this
microneedle
accelerates
without
systemic
toxicity.
RNA
transcriptome
sequencing
illustrates
HA
migration
inhibits
reactions
damage
NF-κB
signaling
pathway.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 16, 2024
The
immunosuppressive
tumor
microenvironment
(TME)
is
a
huge
hurdle
in
immunotherapy.
Sono-immunotherapy
new
treatment
modality
that
can
reverse
TME,
but
the
sonodynamic
effects
are
compromised
by
overexpressed
glutathione
(GSH)
and
hypoxia
TME.
Herein,
this
work
reports
sono-immunotherapy
strategy
using
Pd
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 8, 2024
Sono-immunotherapy
faces
challenges
from
poor
immunogenicity
and
low
response
rate
due
to
complex
biological
barriers.
Herein,
we
prepared
MCTH
nanocomposites
(NCs)
consisting
of
disulfide
bonds
(S-S)
doped
mesoporous
organosilica
(MONs),
Cu-modified
protoporphyrin
(CuPpIX),
mitochondria-targeting
triphenylphosphine
(TPP),
CD44-targeting
hyaluronic
acid
(HA).
NCs
efficiently
accumulate
at
the
tumor
site
overexpressed
CD44
receptors
on
membrane
cancer
cells.
Under
function
HAase
glutathione
(GSH),
degrades
exposes
TPP
deliver
CuPpIX
mitochondrial
induce
a
reactive
oxygen
species
(ROS)
burst
in
situ
under
ultrasound
irradiations,
thereby
causing
severe
mitochondria
dysfunction.
This
cascade-targeting
ability
not
only
reinforces
oxidative
stress
cells
but
also
amplifies
immunogenic
cell
death
(ICD)
stimulate
body's
immune
alleviate
immunosuppressive
microenvironment.
These
significantly
enhance
infiltration
into
tumor,
particularly
CD8+
T
cells,
for
powerful
antitumor
sono-immunotherapy.
The
proposed
strategy
holds
promise
strengthening
sono-immunotherapy
prostate
treatment
overcoming
limitations
traditional
immunotherapy.
