A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(28)

Published: May 9, 2022

Abstract The clinical application of photodynamic therapy is hindered by the high glutathione concentration, poor cancer‐targeting properties, drug loading into delivery systems, and an inefficient activation cell death machinery in cancer cells. To overcome these limitations, herein, formulation a promising Ir III complex biodegradable coordination polymer ( IrS NPs ) presented. nanoparticles were found to remain stable under physiological conditions but deplete disintegrate monomeric metal complexes tumor microenvironment, causing enhanced therapeutic effect. selectively accumulate mitochondria where trigger hybrid apoptosis ferroptosis pathways through photoinduced production singlet oxygen superoxide anion radicals. This study presents first example that can efficiently cause upon irradiation, providing innovative approach for therapy.

Language: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

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Multimetallic transition metal complexes:Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215656 - 215656

Published: Jan. 19, 2024

Language: Английский

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Label‐free 3D cell imaging using hydrogels functionalized with switchable iridium complexes

Chemistry - A European Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

The use of fluorescent labels is the most common tool to visualize cells. However, internalization dye molecules often modifies cell behavior. In this paper we demonstrate that it possible transiently label cells using a 3D scaffold, hydrogel, covalently functionalized with luminescent cyclometalated iridium(III) complexes. unique feature our design complexes are emissive only when they interact membrane while their emission quenched in water. We exploited perform real-time and staining-free visualization imaging. Iridium hydrogels very weakly immerged culture media. When added them, iridium complexes, linked gel, lipophilic "switches on" luminescence enabling clear dynamic, proliferation. A complete photophysical biological study materials presented which demonstrates potential methodology for 3D-realtime tracking.

Language: Английский

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Harnessing triplet excitons: Advances in luminescence metal coordination compounds

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216066 - 216066

Published: July 15, 2024

Language: Английский

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Luminescence Lifetime-Based Sensing Platform Based on Cyclometalated Iridium(III) Complexes for the Detection of Perfluorooctanoic Acid in Aqueous Samples

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(4), P. 1565 - 1575

Published: Jan. 16, 2024

Luminescence lifetimes are an attractive analytical method for detection due to its high sensitivity and stability. Iridium probes exhibit luminescence with long excited-state lifetimes, which sensitive the local environment. Perfluorooctanoic acid (PFOA) is listed as a chemical of concern regarding toxicity classified "forever chemical". In addition strict limits on presence PFOA in drinking water, environmental contamination from industrial effluent or spills requires rapid, simple, accurate, cost-effective analysis order aid containment. Herein, we report fabrication function novel facile sensor based iridium modified gold surfaces. These surfaces were lipophilic complexes bearing alkyl chains, namely, IrC

Language: Английский

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B-embedded narrowband pure near-infrared (NIR) phosphorescent iridium(III) complexes and solution-processed OLED application

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109596 - 109596

Published: Feb. 2, 2024

Language: Английский

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A hetero-bimetallic Ru(ii)–Ir(iii) photosensitizer for effective cancer photodynamic therapy under hypoxia

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(20), P. 2776 - 2779

Published: Jan. 1, 2024

A hetero-bimetallic Ru( ii )–Ir( iii ) complex Ru-Ir was developed to act as a type-I and type-II dual photosensitizer for effective cancer photodynamic therapy under hypoxia.

Language: Английский

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Bone analysis using an aggregation‐induced emission‐active iridium complex

Aggregate, Journal Year: 2023, Volume and Issue: 4(6)

Published: July 4, 2023

Abstract Fluorescent analysis of bone provides valuable insights into structures. However, conventional dyes suffer from low specificity on tissue, small stokes shift, short fluorescent lifetime, and aggregation‐caused quenching effect, which result in efficacy artifacts. In this work, we design an aggregation‐induced emission (AIE)‐active iridium(III) complex ( Ir‐BP2 ) as a highly selective, convenient, nondestructiveness, dual‐mode staining agent for analysis. containing phosphonate groups selectively binds to hydroxyapatites, the main component matrix, exhibits turn‐on AIE phosphorescence with prolonged lifetime. promising biosafety offers higher accuracy calcium deposits than Alizarin Red S assay when it is employed real‐time monitoring osteogenesis differentiation process. A ready‐to‐use spray fabricated. By using imaging lifetime imaging, microstructure analysis, microdamage diagnosis, growth state identification. Further, successfully applied human spine vertebra diagnosing invasiveness eosinophilic granuloma, validating its clinical practice. This work presents powerful tool will lead new approaches diagnosis treatment bone‐related diseases.

Language: Английский

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Exploring the Versatile Uses of Triplet States: Working Principles, Limitations, and Recent Progress in Phosphorescence, TADF, and TTA

ACS Applied Optical Materials, Journal Year: 2024, Volume and Issue: 2(12), P. 2476 - 2500

Published: April 19, 2024

Triplet excited states in organic semiconductors are usually optically dark and long-lived as they have a spin-forbidden transition to the singlet ground state therefore hinder processes light-harvesting applications. Also, triplets often cause damage system can sensitize formation of reactive oxygen. Despite these unfavorable characteristics, there exist mechanisms through which we utilize triplet states, that constitutes scope this review. Commencing with an introductory short exploration problem, proceed elucidate principal underpinning utilization materials: 1. Phosphorescence (PH), 2. Thermally Activated Delayed Fluorescence (TADF), 3. Triplet-Triplet Annihilation (TTA). In each section unveil their working principles, highlight vast range applications, discuss limitations perspectives. We dedicate special attention use light-emitting diodes (OLEDs), given OLEDs represent most thriving commercial application semiconductors. This review aims provide readers insights opportunities engage contribute study photophysical properties device physics semiconductors, especially regarding harnessing potential states.

Language: Английский

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