Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216148 - 216148
Published: Aug. 16, 2024
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Jan. 12, 2023
Skin cancer has emerged as the fifth most commonly reported in world, causing a burden on global health and economy. The enormously rising environmental changes, industrialization, genetic modification have further exacerbated skin statistics. Current treatment modalities such surgery, radiotherapy, conventional chemotherapy, targeted therapy, immunotherapy are facing several issues related to cost, toxicity, bioavailability thereby leading declined anti-skin therapeutic efficacy poor patient compliance. In context of overcoming this limitation, nanotechnological advancements been witnessed so far. Among various nanomaterials, nanoparticles endowed exorbitant advantages by acting both agents drug carriers for remarkable cancer. small size large surface area volume ratio escalate tumor uptake through their leaky vasculature resulting enhanced efficacy. context, present review provides up date information about different types pathology cancer, followed current associated drawbacks. Furthermore, it meticulously discusses role numerous inorganic, polymer, lipid-based therapy with subsequent descriptions patents clinical trials.
Language: Английский
Citations
195
ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405
Published: July 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Language: Английский
Citations
194
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114793 - 114793
Published: March 22, 2023
Language: Английский
Citations
95
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: July 26, 2022
Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical
Language: Английский
Citations
83
Chemistry - A European Journal, Journal Year: 2022, Volume and Issue: 29(11)
Published: Dec. 22, 2022
The preparation of multifunctionalized luminophores with full-color emission based on an identical core skeleton is a significative but challenging research topic. In this work, eight donor-donor-acceptor (D-D-A)-type luminogens central carbazole bearing C6 hydrocarbon chain were designed by using different kinds donor and acceptor units the left right, synthesized in good yields. These D-D-A derivatives display deep-blue, sky-blue, cyan, green, yellow-green, yellow, orange red fluorescence solid state, achieving covering whole visible light range under UV illumination. Notably, dicyano-functionalized triphenylamine-containing derivative exhibits rare aggregation-induced near-infrared red-to-near-infrared mechano-fluorochromism high contrast beyond 100 nm. Furthermore, red-emissive luminogen can serve as potential candidate for cell imaging photodynamic therapy (PDT). This work not only provides reference construction emissive systems also opens new avenue to capable simultaneous application near-Infrared mechanical-force sensors PDT fields.
Language: Английский
Citations
71
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 487, P. 215154 - 215154
Published: April 11, 2023
Language: Английский
Citations
42
BMEMat, Journal Year: 2024, Volume and Issue: 2(3)
Published: April 24, 2024
Abstract The development of novel photosensitizers (PSs) with aggregation‐induced emission (AIE) properties has emerged as a crucial advancement in the field photodynamic therapy (PDT). However, versatile applications AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability. Biomimetic technology stands out promising strategy to overcome these challenges, aiming enhance tumor penetration efficacy, their association antitumor immune responses. In this review, recent advancements biomimetic for PDT immunotherapy summarized. We start introducing strategies involving based on cell membranes extracellular vesicles combined application immunotherapy. then discuss preparation nanoparticles. Finally, we briefly outline challenges prospects associated PSs.
Language: Английский
Citations
19
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 406, P. 135432 - 135432
Published: Feb. 2, 2024
Language: Английский
Citations
18
ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306
Published: Jan. 2, 2025
A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.
Language: Английский
Citations
6
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 330, P. 125738 - 125738
Published: Jan. 10, 2025
Language: Английский
Citations
2