Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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Tuning Local Coordination Environments of Manganese Single‐Atom Nanozymes with Multi‐Enzyme Properties for Selective Colorimetric Biosensing

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(15)

Published: Feb. 13, 2023

Single-atom nanozymes (SAzymes) are promising in next-generation nanozymes, nevertheless, how to rationally modulate the microenvironment of SAzymes with controllable multi-enzyme properties is still challenging. Herein, we systematically investigate relationship between atomic configuration and multi-enzymatic performances. The constructed MnSA -N3 -coordinated (MnSA -C) exhibits much more remarkable oxidase-, peroxidase-, glutathione oxidase-like activities than that -N4 -C. Based on experimental theoretical results, these multi-enzyme-like behaviors highly dependent coordination number single Mn sites by local charge polarization. As a consequence, series colorimetric biosensing platforms based -C successfully built for specific recognition biological molecules. These findings provide atomic-level insight into promoting rational design other demanding biocatalysts.

Language: Английский

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Recent Progress in Emerging Novel MXenes Based Materials and their Fascinating Sensing Applications

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 8, 2023

Early transition metals based 2D carbides, nitrides and carbonitrides nanomaterials are known as MXenes, a novel extensive new class of materials family. Since the first accidently synthesis discovery Ti3 C2 in 2011, more than 50 additional compositions have been experimentally reported, including at least eight distinct methods also 100 stoichiometries theoretically studied. Due to its distinctive surface chemistry, graphene like shape, metallic conductivity, high hydrophilicity, outstanding mechanical thermal properties, redox capacity affordable with mass-produced nature, this diverse MXenes tremendous scientific technological significance. In review, we'll come across MXene possible methods, their advantages, limitations future suggestions, chemistry related selected properties potential sensing applications, which will help us explain why family is growing very fast compared other families. Secondly, problems that further improve commercialization sensors examined, many advances commercializing proposed. At end, go through current challenges, suggestions.

Language: Английский

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Activity Regulating Strategies of Nanozymes for Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Language: Английский

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Advances in the application of metal oxide nanozymes in tumor detection and treatment

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113767 - 113767

Published: Jan. 24, 2024

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Language: Английский

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Recent advances in MXenes: a future of nanotechnologies

Journal of Materials Chemistry A, Journal Year: 2023, Volume and Issue: 11(37), P. 19764 - 19811

Published: Jan. 1, 2023

Two-dimensional (2D) materials are amongst the most interesting scientific research in twenty-first century.

Language: Английский

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Nanozyme-based strategies for efficient theranostics of brain diseases

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215519 - 215519

Published: Dec. 1, 2023

Language: Английский

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Construction and Application of Nanozyme Sensor Arrays

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8221 - 8233

Published: May 13, 2024

Compared with traditional "lock–key mode" biosensors, a sensor array consists of series sensing elements based on intermolecular interactions (typically hydrogen bonds, van der Waals forces, and electrostatic interactions). At the same time, arrays also have advantages fast response, high sensitivity, low energy consumption, cost, rich output signals, imageability, which attracted widespread attention from researchers. Nanozymes are nanomaterials own enzyme-like properties. Because adjustable activity, stability, cost effectiveness nanozymes, they potential candidates for construction to different signals analytes through chemoresponse colorants, solves shortcomings sensors that cannot support multiple detection lack universality. Recently, nanozymes as nonspecific recognition receptors has much more researchers been applied precise proteins, bacteria, heavy metals. In this perspective, is given regulation their activity. Particularly, building principles methods analyzed, applications summarized. Finally, approaches overcome challenges perspectives presented analyzed facilitating further research development nanozyme arrays. This perspective should be helpful gaining insight into ideas within field

Language: Английский

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