Synergizing Pyroelectric Catalysis and Enzyme Catalysis: Establishing a Reciprocal and Synergistic Model to Enhance Anti‐Tumor Activity DOI
Yan Wang, Rui Zhang,

Pengyu Zang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: Feb. 27, 2024

Nanozyme activity is greatly weakened by the microenvironment and multidrug resistance of tumor cells. Hence, a bi-catalytic nanoplatform, which promotes anti-tumor through "charging empowerment" "mutual complementation" processes involved in enzymatic pyroelectric catalysis, loading ultra-small nanoparticles (USNPs) ZnSnO

Language: Английский

Artificial enzyme mimics cascade catalysis for signal amplification and transduction in food quality determination: An overview of fundamentals and recent advances DOI
Yuechun Li,

Qinyuan Bao,

Ziqi Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215689 - 215689

Published: Feb. 8, 2024

Language: Английский

Citations

25
Self-Assembled Integrated Nanozyme Cascade Biosensor with Dual Catalytic Activity for Portable Urease Analysis DOI

Meini Li,

Yunfei Xie, Jiabao Zhang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(3), P. 1284 - 1292

Published: Jan. 9, 2024

In this work, a novel nanozyme (Cu@Zr) with all-in-one dual enzyme and fluorescence properties is designed by simple self-assembly. A cascade sensor disodium phenyl phosphate (PPDS) as substrate was first established exploiting the enzymatic activities of phosphatase laccase. Specifically, cleaves P–O bond PPDS to produce colorless phenol, which then oxidized laccase complexed chromogenic agent 4-aminoantipyrine (4-AP) red quinoneimine (QI). Strikingly, NH3 produced urease hydrolysis urea can interact Cu@Zr, accelerating electron transfer rate ultimately leading significantly improved performance reaction. Moreover, at 440 nm Cu@Zr further quenched inner filter effect (IFE) QI. Thus, colorimetric dual-mode strategy for sensitive analysis LODs 3.56 1.83 U/L proposed sensor. Notably, portable swab loaded also prepared in situ detection aid smartphone RGB readout. It provides potentially viable analytical avenue environmental biological analysis.

Language: Английский

Citations

22
Applications of mild-condition synthesized metal complexes with enzyme-like activity in the colorimetric and fluorescence analysis DOI
Guoying Chen,

Tong-Qing Chai,

Hao Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215761 - 215761

Published: March 12, 2024

Language: Английский

Citations

22
Coordinated carbon dots-Fe featuring synergistically enhanced peroxidase-like activity at neutral pH for specific and background-free detection of dichlorvos DOI

Yangyu Yang,

Jinju Xu,

Rongrong Zhou

et al.

Carbon, Journal Year: 2024, Volume and Issue: 219, P. 118831 - 118831

Published: Jan. 17, 2024

Language: Английский

Citations

20
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

3
A novel strategy for identification of pesticides in different categories by concentration-independent model based on a nanozyme with multienzyme-like activities DOI
Donghui Song,

Lulu Lei,

Tian Tian

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115458 - 115458

Published: June 8, 2023

Language: Английский

Citations

32
Novel gold nanozyme regulation strategies facilitate analytes detection DOI
Zhengzheng Wang,

Yanna Shao,

Zhenjun Zhu

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215369 - 215369

Published: Aug. 10, 2023

Language: Английский

Citations

32
Multienzyme‐Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment DOI
Shen Liu, Qiang Bai, Yujie Jiang

et al.

Small, Journal Year: 2023, Volume and Issue: 20(21)

Published: Dec. 15, 2023

Abstract Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one leading causes severe visual disability and blindness. Keratitis treatment requires both prevention infection reduction inflammation. However, owing to their limited therapeutic functions, in addition ocular barrier, existing conventional medications are characterized poor efficacy low bioavailability, requiring high dosages frequent topical treatment, which represents a burden on patients increases risk side effects. In this study, manganese oxide nanocluster‐decorated graphdiyne nanosheets (MnO x /GDY) developed as multienzyme‐like nanozymes for infectious keratitis loaded into hyaluronic acid polymethyl methacrylate‐based microneedles (MGMN). MGMN not only exhibits antimicrobial anti‐inflammatory effects its activities, including oxidase, peroxidase, catalase, superoxide dismutase mimics but also crosses barrier shows increased bioavailability via microneedle system. Moreover, demonstrated eliminate pathogens, prevent biofilm formation, reduce inflammation, alleviate hypoxia, promote repair corneal epithelial damage vitro, ex vivo, vivo experiments, thus providing better effect than commercial ophthalmic voriconazole, with no obvious microbial resistance cytotoxicity.

Language: Английский

Citations

32
Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers DOI

Quan Wei,

Wenhui Song, Qian Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215407 - 215407

Published: Sept. 12, 2023

Language: Английский

Citations

29
Two dimensional borophene nanomaterials: Recent developments for novel renewable energy storage applications DOI
Chuan Li, Ayesha Khan Tareen, Jianyu Long

et al.

Progress in Solid State Chemistry, Journal Year: 2023, Volume and Issue: 71, P. 100416 - 100416

Published: Aug. 15, 2023

Language: Английский

Citations

28