Frontiers in Chemistry,
Journal Year:
2023,
Volume and Issue:
11
Published: March 30, 2023
Uncontrolled
hemorrhage
caused
by
trauma
can
easily
lead
to
death.
Efficient
and
safe
hemostatic
materials
are
an
urgent
increasing
need
for
research.
Following
a
trauma,
wound
healing
is
induced
various
cellular
mechanisms
proteins.
Hemostatic
biomaterials
that
not
only
halt
bleeding
quickly
but
also
provide
environment
promote
have
been
the
focus
of
research
in
recent
years.
Mussel-inspired
nanoparticle
composite
hydrogels
propelling
development
owing
their
unique
advantages
adhesion,
hemostasis,
bacteriostasis.
This
review
summarizes
antimicrobial
fundamentals
polydopamine
(PDA)-based
nanomaterials
emphasizes
current
developments
hemorrhage-related
PDA
nanomaterials.
Moreover,
it
briefly
discusses
safety
concerns
clinical
application
problems
with
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10540 - 10540
Published: June 23, 2023
Hemorrhage
is
a
detrimental
event
present
in
traumatic
injury,
surgery,
and
disorders
of
bleeding
that
can
become
life-threatening
if
not
properly
managed.
Moreover,
uncontrolled
complicate
surgical
interventions,
altering
the
outcome
procedures.
Therefore,
to
reduce
risk
complications
decrease
morbidity
mortality
associated
with
hemorrhage,
it
necessary
use
an
effective
hemostatic
agent
ensures
immediate
control
bleeding.
In
recent
years,
there
have
been
increasingly
rapid
advances
developing
novel
generation
biomaterials
properties.
Nowadays,
wide
array
topical
agents
available,
including
chitosan-based
shown
outstanding
properties
such
as
antibacterial,
antifungal,
hemostatic,
analgesic
activity
addition
their
biocompatibility,
biodegradability,
wound-healing
effects.
This
review
provides
analysis
discusses
progress
made
performance,
mechanism
action,
efficacy,
cost,
safety
years.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(36)
Published: May 18, 2023
Abstract
Rapid
and
effective
hemostasis
on
irregular‐shaped
non‐compressible
bleeding
wounds
is
still
one
of
the
key
challenges
in
clinical
practice.
Herein,
a
novel
multi‐functional
microgel
assembly
powder
(MAP)
composed
oxidized
dextran/methacrylate
gelatin
(ODex/GelMA)
long‐chain
alkyl
quaternized
chitosan
(LQCS)
crosslinker
reported
for
acute
hemostasis,
antibacterial,
wound
healing.
When
MAP
applied
onto
wounds,
porous
ODex/GelMA
immediately
absorbs
massive
liquid
blood
whilst
LQCS
induces
situ
co‐assembly
erythrocytes
microgels.
In
other
words,
combines
merits
hemostatic
powders
hydrogels,
that
is,
excellent
performance
originated
from
not
only
high
fluid
uptake
ratio/rate
causes
aggregation
coagulation
factors
erythrocytes,
but
also
formation
erythrocytes‐involved
hydrogel‐like
dramatically
improves
mechanical
strength,
tissue
adhesion
sealing
compared
with
those
PBS.
addition,
exhibits
antibacterial
ability,
promotes
healing
bacterial‐infected
full‐thickness
skin
wounds.
The
fantastic
features
including
low
cost,
easy
synthesis
usage,
irregular‐shaped,
outstanding
healing,
good
cytocompatibility,
make
it
promising
material
dressing.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 14, 2024
Abstract
Uncontrolled
bleeding
and
wound
infections
following
severe
trauma
pose
significant
challenges
for
existing
tissue
adhesives,
primarily
due
to
their
weak
wet
adhesion,
slow
adhesion
formation,
cytotoxicity
concerns,
lack
of
antibacterial
properties.
Herein,
an
injectable
hydrogel
(denoted
as
ES
gel)
with
rapid,
robust
adhesive
sealing
inherent
activity
based
on
ε‐polylysine
a
poly(ethylene
glycol)
derivative
is
developed.
The
engineered
exhibits
rapid
gelation
behavior,
high
mechanical
strength,
strong
various
tissues,
can
sustain
ultrahigh
burst
pressure
450
mmHg.
It
also
presents
excellent
biocompatibility,
biodegradability,
properties,
on‐demand
removability.
Significantly
improved
hemostatic
efficacy
gel
compared
fibrin
glue
demonstrated
using
injury
models
in
rats
rabbits.
Remarkably,
the
effectively
halt
lethal
non‐compressible
hemorrhages
visceral
organs
(liver,
spleen,
heart)
femoral
artery
fully
anticoagulated
pigs.
Furthermore,
outperforms
commercial
products
sutureless
closure
repair
rat
liver
defect,
skin
incision,
infected
full‐thickness
models.
Overall,
this
study
highlights
promising
clinical
applications
managing
uncontrolled
hemorrhage,
closure,
repair.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(3), P. 457 - 477
Published: March 3, 2024
Introduction
Immediate
control
of
bleeding
and
anti-infection
play
important
roles
in
wound
management.
Multiple
organ
dysfunction
syndrome
death
may
occur
if
persistent
bleeding,
hemodynamic
instability,
hypoxemia
are
not
addressed.
The
combination
clay
hydrogel
provides
a
new
outlet
for
hemostasis.
In
this
review,
the
current
research
progress
hydrogel/clay
composite
hemostatic
agents
was
reviewed.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Oct. 10, 2023
Abstract
Bleeding
to
death
accounts
for
around
30–40%
of
all
trauma‐related
fatalities.
Current
hemostatic
materials
are
mainly
mono‐functional
or
have
insufficient
capacity.
Nanoclay
has
been
recently
shown
accelerate
hemostasis,
improve
wound
healing,
and
provide
the
resulting
multifunctional
antibacterial,
anti‐inflammatory,
healing‐promoting
due
its
distinctive
morphological
structure
physicochemical
properties.
Herein,
chemical
design
action
mechanism
nanoclay‐based
hemostatic,
pro‐wound
healing
in
context
discussed.
The
physiological
processes
hemostasis
elucidate
significance
nanoclay
functional
dressing
outlined.
A
summary
features
various
product
types
used
dressings
is
provided.
can
be
antimicrobial
slow
release
metal
ions
an
abundant
surface
charge
allowing
high
affinity
proteins
cells,
which
activate
coagulation
reaction
facilitate
tissue
repair.
with
a
microporous
as
drug
carriers
create
composites
critical
inhibiting
bacterial
growth
on
wounds
promoting
regeneration
vascular,
muscle,
skin
tissues.
Directions
further
research
innovation
explored.
Small,
Journal Year:
2023,
Volume and Issue:
20(22)
Published: Dec. 15, 2023
Hemorrhage
remains
a
critical
challenge
in
various
medical
settings,
necessitating
the
development
of
advanced
hemostatic
materials.
Hemostatic
hydrogels
have
emerged
as
promising
solutions
to
address
uncontrolled
bleeding
due
their
unique
properties,
including
biocompatibility,
tunable
physical
characteristics,
and
exceptional
capabilities.
In
this
review,
comprehensive
overview
preparation
biomedical
applications
is
provided.
Particularly,
with
materials
forms
are
introduced.
Additionally,
trauma
management,
surgical
procedures,
wound
care,
etc.
summarized.
Finally,
limitations
future
prospects
discussed
evaluated.
This
review
aims
highlight
hemorrhage
management
offer
insights
into
clinically
relevant
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(13), P. 4430 - 4451
Published: Jan. 1, 2023
Wound
management
is
a
serious
concern
worldwide,
inflicting
huge
social
and
economic
burden
on
patients
healthcare
systems,
research
into
efficient
wound-management
measures
crucial.
