Rapidly Photocurable and Strongly Adhesive Hydrogel‐Based Sealant with Good Procoagulant Activity for Lethal Hemorrhage Control DOI

Yan-Jue Lv,

Yanyan Xu, Shuxiang Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Lethal bleeding from severe trauma or surgical injuries to vital organs threatens the lives of patients. Advanced design efficient hemostatic sealants endowed with both rapid curing and strong tissue adhesion remains a considerable challenge. This study proposes novel strategy that implements covalent linkages biological tissues during sealant curing. A rapidly photocurable strongly adhesive based on diazirine‐conjugated chitosan (DC) is successfully developed, demonstrating gelation time 8 s burst pressure 200 mmHg. The DC accelerates in vitro clotting by facilitating aggregation erythrocytes platelets, as well platelet activation. In liver perforation model, substantially promotes healing hepatic wounds improves survival. not only achieves hemostasis incision, femoral artery perforation, cardiac but also recovery rabbit model. phototriggered opens up new avenue for clinical applications, particularly lethal hemorrhage.

Language: Английский

Hydroxypropyl methylcellulose reinforced collagen/PVA composite hydrogel wound dressing with self-adaptive, hemostasis and antibacterial ability for wound healing DOI

L. Ding,

Qianfen Qi,

Susu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140811 - 140811

Published: Feb. 12, 2025

Language: Английский

Citations

6
Theranostic hydrogels: Construction strategies and applications DOI

Xiaolong Li,

Ruiyang Li, Fuxiao Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159545 - 159545

Published: Jan. 13, 2025

Language: Английский

Citations

3
Anisotropic Shape‐Memory Cryogel with Oriented Macroporous Channel for Hemorrhage Control and Tissue Generation DOI Open Access
Zheng Pan, Gang He,

Yiwen Xian

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous channels made biocompatible polymers (poly(ethylene glycol), gelatin, lignin) through simple one‐step cryo‐structuration process. This structural alignment provides the cryogel with low water flow resistance, efficient fluid transport, rapid shape recovery. SALC demonstrates superior adsorption retention, vitro tamponade sealing, pro‐coagulant properties compared to commercial gelatin sponges XSTAT, along favorable biocompatibility biodegradability. The efficacy surpasses clinically used counterparts rat models liver perforation femoral artery transection. Remarkably, achieves effective porcine hepatic, artery, cardiac injuries. Additionally, supports tissue regeneration by promoting cell migration angiogenesis while mitigating inflammatory responses. is also lightweight easy carry implement. Overall, shows clinical applications treating hemorrhages improving healing.

Language: Английский

Citations

2
Ways forward with conductive hydrogels: Classifications, properties, and applications in flexible electronic and energy gadgets DOI
Weilin Zhang, Hongjian Zhang, Hyunseung Kim

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100923 - 100923

Published: Jan. 8, 2025

Language: Английский

Citations

1
Double‐Dynamic‐Bond Cross‐Linked Hydrogel Adhesive with Cohesion‐Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing DOI Open Access
Ming Yan, Shiyu Hu,

H TAN

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing repair. However, the negative correlation between mechanical strength poses a challenge their practical application. Herein, bio‐inspired cohesive enhancement strategy is developed to prepare adhesive simultaneously enhanced adhesion. double cross‐linked network achieved through cooperation polyacrylic acid grafted N‐hydroxy succinimide crosslinked by tannic cohesion‐enhanced ion crosslinking of sodium alginate Ca 2+ . Such unique structure endows resultant excellent strength. capable various organs in vitro, exhibits satisfactory on‐demand removability, antibacterial, antioxidant properties. As proof concept, not only effectively halts non‐compressible hemorrhages beating heart femoral artery models rats, but also accelerates healing infected wound inhibiting bacteria reducing inflammation. Overall, this advanced promising as an emergency rescue that enables robust closure, timely controlling bleeding, promoting damaged healing.

Language: Английский

Citations

1
Hemoadhican Fiber Composite with Carbon Dots for Treating Severe Hemorrhage and Infected Wounds DOI

Rui Fang,

Ning Yu,

Fa Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Uncontrolled bleeding and infection following trauma continue to pose significant clinical challenges. This study employs hemoadhican (HD) polysaccharide, known for its superior hemostatic properties, as the foundational material synthesize antibacterial carbon dots (H-CDs) through a hydrothermal method at various temperatures. The H-CDs exhibiting optimal antimicrobial properties were identified via in vitro characterization. selected possess nanoscale dimensions positive surface charge. They contain aldehyde groups generate reactive oxygen species, which effectively eliminate bacteria. Subsequently, integrated into HD fibers (CDs-HD fibers) using wet-spinning technique. water vapor transmission rate, blood contact angle, efficacy evaluated. In rat model of severe femoral artery hemorrhage noncompressible hepatic model, CDs-HD demonstrated performance compared commercially available QuikClot Combat Gauze. Furthermore, mixed bacterial wound infection, significantly enhanced epithelial tissue remodeling collagen deposition. vivo studies confirmed excellent biocompatibility fibers. These findings suggest that hold promise potential dressing managing preventing infections.

Language: Английский

Citations

1
Facile preparation of carboxymethyl chitosan/dextran/poly(ionic liquid)-based hydrogel with intrinsic antibacterial and antioxidant properties for accelerating skin wound healing DOI
Qingcong Wei, Xia Liao, Zhenwei Cui

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140851 - 140851

Published: Feb. 9, 2025

Language: Английский

Citations

1
Tissue‐Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria‐Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis DOI Open Access
Yang Gao, Xinxin Chen, Zheng Zou

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Effective treatment of diabetic wounds remains challenging because multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive antibacterial hydrogel incorporating MXene deferoxamine (DFO)-loaded microspheres is developed for the MDR bacteria-infected wounds. The built based on covalent crosslinking between ε-poly(L-lysine) o-phthalaldehyde-terminated four-arm poly(ethylene glycol). exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, biodegradability. Under near-infrared (NIR) irradiation, converted light into heat elevated local temperature rapidly, enabling rapid disintegration biofilms. Simultaneously, exerted inherent activity, persistently killing planktonic bacteria, effectively controlling wound infections. encapsulated DFO then released from in sustained controlled manner, promoted angiogenesis during healing. Additionally, MXenes can scavenge reactive oxygen species alleviate inflammation. methicillin-resistant Staphylococcus aureus-infected model mice, composite along with NIR irradiation efficiently reduced infectious accelerated healing by promoting alleviating This has great clinical potential wounds, particularly environments involving motion infection.

Language: Английский

Citations

1
Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications DOI Open Access

Wenguang Dou,

Xiaojun Zeng,

Shuzhuang Zhu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9100 - 9100

Published: Aug. 22, 2024

The impressive adhesive capacity of marine mussels has inspired various fascinating designs in biomedical fields. Mussel-inspired injectable hydrogels, as a type promising mussel-inspired material, have attracted much attention due to their minimally invasive property and desirable functions provided by components. In recent decades, hydrogels been designed widely applied numerous rational incorporation catechol groups endows the with potential exhibit many properties, including tissue adhesiveness self-healing, antimicrobial, antioxidant capabilities, broadening applications this review, we first give brief introduction adhesion mechanism characteristics hydrogels. Further, typical design strategies are summarized. methodologies for integrating into polymers crosslinking methods discussed section. addition, systematically overview applications, focus on how unique properties these benefit challenges perspectives last This review may provide new inspiration novel bioinspired facilitate application

Language: Английский

Citations

4
Freestanding Hydrogen‐Bonded Organic Framework Membrane for Efficient Wound Healing DOI
Lingling Wu, Xue Yang,

Haonan Jia

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging as multifunctional materials with exceptional biocompatibility, abundant active sites, and tunable porosity, which highly beneficial for advanced wound care. However, a significant challenge involves transforming pristine HOFs powders into lightweight, ultrathin, freestanding membranes compatible soft biological systems. Herein, the study successfully develops shape‐adaptive HOF‐based matrix (HMMs) using polymer‐assisted liquid‐air interface technique. The HMMs conform seamlessly to tissues of different sizes shapes, effectively stopping bleeding, provide high water‐vapor permeability. Notably, both in vitro vivo studies mice models demonstrated that these tissue‐conformable significantly accelerate healing by modulating inflammatory environment injured tissue promoting rapid re‐epithelialization. Furthermore, RNA‐seq analysis mechanistic revealed reduce inflammation facilitate transition from proliferative stage remodeling skin development. This work not only opens up new avenues care but also establishes foundation hybridizing polymers wide range potential applications.

Language: Английский

Citations

4