Communications Chemistry,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Aug. 13, 2024
Abstract
Mitochondrial
dysregulation
plays
a
significant
role
in
the
carcinogenesis.
On
other
hand,
its
destabilization
strongly
represses
viability
and
metastatic
potential
of
cancer
cells.
Photodynamic
photothermal
therapies
(PDT
PTT)
target
mitochondria
effectively,
providing
innovative
non-invasive
anticancer
therapeutic
modalities.
Cyanine
dyes,
with
strong
mitochondrial
selectivity,
show
enhancing
PDT
PTT.
The
limitations
cyanine
dyes
for
PTT
are
discussed,
along
their
applications
combination
therapies,
theranostic
techniques,
optimal
delivery
systems.
Additionally,
novel
approaches
sonodynamic
therapy
using
photoactive
presented,
highlighting
advances
treatment.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
Phototheranostics
has
garnered
sustained
attention
due
to
its
significant
potential
for
revolutionizing
conventional
cancer
treatment
strategies.
While
being
one
of
the
most
commonly
employed
strategies
constructing
phototheranostic
systems
by
engineering
integration
photosensitizers
(PSs)
into
nanosystems,
nano‐PSs
face
challenges
including
complexity
in
preparation
process,
low
delivery
efficiency,
and
toxicity
issues.
Contrastingly,
burgeoning
popularity
small
molecule
PSs
characterized
aggregation‐induced
emission
(AIE)
become
evident
arena
phototheranostics.
This
preference
is
underscored
their
well‐defined
structures,
adjustable
photophysical
properties,
toxicity.
Therefore,
acquiring
profound
insights
pioneering
strides
achievable
through
a
solitary
PS
with
AIE
tumor
phototheranostics
paramount
scientific
significance.
In
this
review,
we
will
discuss
recent
progress
properties
diagnosis
phototherapies
representative
examples,
guided
ethos
“Complexity
made
easy”.
We
also
look
forward
future
development
direction
molecules,
central
objective
advancing
research
focal
emphasis
on
simplicity,
expeditiousness,
safety.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 7, 2024
Abstract
The
post‐surgical
melanoma
recurrence
and
wound
infections
have
persistently
troubled
clinical
management.
Piezocatalytic
therapy
features
high
efficiency
in
generating
reactive
oxygen
species
(ROS)
for
tumor
therapy,
but
it
faces
limitations
piezoelectricity
redox‐active
site
availability.
Herein,
Fe‐doped
ultrathin
Bi
4
Ti
3
O
12
nanosheets
(designated
as
Fe‐UBTO
NSs)
with
synergistically
piezo‐chemocatalytic
activity
are
engineered
antitumor
antibacterial
treatment
against
cutaneous
melanoma.
doping‐engineered
strategy
induces
vacancies
lattice
distortions
NSs,
which
narrows
bandgap
to
enhance
piezocatalytic
1
2
H
generation
by
improving
the
electron‐hole
pairs
separation,
hindering
their
recombination,
increasing
adsorption.
Moreover,
Fe
doping
establishes
a
system,
piezocatalysis
enables
self‐supply
of
expedites
electron
transfer
Fenton
reactions,
inducing
increased
·OH
production.
Besides,
atomic‐level
thickness
expanded
surface
area
sensitivity
ultrasound
stimuli
expose
more
sites,
augmenting
efficiency,
ultimately
leading
abundant
ROS
generation.
Fe‐UBTO‐mediated
causes
intracellular
oxidative
stress,
triggering
apoptosis
excessive
autophagy
cells.
this
accelerates
healing
facilitating
sterilization,
angiogenesis,
collagen
deposition.
This
work
provides
distinct
options
develop
augmented
postoperative
management
Communications Chemistry,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Aug. 13, 2024
Abstract
Mitochondrial
dysregulation
plays
a
significant
role
in
the
carcinogenesis.
On
other
hand,
its
destabilization
strongly
represses
viability
and
metastatic
potential
of
cancer
cells.
Photodynamic
photothermal
therapies
(PDT
PTT)
target
mitochondria
effectively,
providing
innovative
non-invasive
anticancer
therapeutic
modalities.
Cyanine
dyes,
with
strong
mitochondrial
selectivity,
show
enhancing
PDT
PTT.
The
limitations
cyanine
dyes
for
PTT
are
discussed,
along
their
applications
combination
therapies,
theranostic
techniques,
optimal
delivery
systems.
Additionally,
novel
approaches
sonodynamic
therapy
using
photoactive
presented,
highlighting
advances
treatment.
