Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(22)
Published: Sept. 27, 2023
Pyrazinamide
is
an
important
medicine
used
for
the
treatment
of
tuberculosis(TB).
The
preparation
pyrazinamide
via
catalytic
hydration
2-cyanopyrazine
great
economic
interest
with
high
atomic
economy.
Heterogeneous
non-precious
transition
metal-catalyzed
nitriles
under
neutral
reaction
conditions
would
be
rather
attractive.
Herein
vanadium-nitrogen-carbon
materials
were
fabricated
and
employed
selective
using
water
as
both
solvent
reactant.
2-Cyanopyrazine
could
smoothly
converted
into
to
unique
substrate
specificity.
Additives
different
N
O
atoms
significantly
affect
due
competitive
adsorption/coordination
in
system.
This
work
provides
a
new
approach
metal
catalyzed
nitriles.
Dalton Transactions,
Journal Year:
2024,
Volume and Issue:
53(30), P. 12503 - 12518
Published: Jan. 1, 2024
Nickel
and
palladium
NHC
complexes
with
fluorine
substituents
have
been
synthesized.
Their
electronic
parameters,
including
σ-donation
π-acceptance,
were
evaluated,
considering
the
position
number
of
substituents.
Dalton Transactions,
Journal Year:
2023,
Volume and Issue:
52(38), P. 13608 - 13617
Published: Jan. 1, 2023
We
report
a
new
class
of
sterically-unsymmetrical
NHC
ligands.
The
evaluation
steric,
electronic
properties
and
coordination
chemistry
is
described.
Studies
catalytic
activity
in
Ag,
Pd
Rh-catalyzed
reactions
are
presented.
Catalysis Science & Technology,
Journal Year:
2023,
Volume and Issue:
13(17), P. 5131 - 5139
Published: Jan. 1, 2023
We
report
[Au(NHC)Cl]
complexes
featuring
IPr#
ligands
that
hinge
upon
modular
peralkylation
of
aniline.
Wingtip-flexible
[Au(Np#)Cl]
is
a
broadly
applicable
catalyst
with
the
reactivity
outperforming
[Au(IPr)Cl]
and
[Au(IPr*)Cl]
complexes.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(17), P. 4081 - 4081
Published: Aug. 28, 2024
In
this
work,
we
have
prepared
and
characterized
some
gold
compounds
wearing
a
N-heterocyclic
carbene
(NHC)
ligand
as
well
alkynyl
derivatives
with
different
substituents.
The
study
of
their
electrochemical
behavior
reveals
that
these
complexes
show
an
irreversible
wave
at
potentials
ranging
between
−2.79
−2.91
V,
referenced
to
the
ferrocenium/ferrocene
pair.
DFT
calculations
indicate
reduction
occurs
mainly
on
aryl−C≡C
fragment.
cyclic
voltammetry
experiments
under
CO2
atmosphere
increase
in
faradaic
current
compared
argon
atmosphere,
indicating
possible
catalytic
activity
towards
carbon
dioxide
reaction
(CO2RR).
European Journal of Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(33)
Published: Aug. 29, 2024
Abstract
A
ruthenium(II)
aquo
complex
[Ru(dipic)(PPh
3
)
2
(OH
)],
(
1
),
bearing
O,N,O‐coordinated
2,6‐dipicolinate
was
synthesized
via
reaction
of
[Ru(PPh
Cl
]
with
2,6‐dipicolinic
acid.
Crystal
structure
determined.
Utilizing
as
a
synthon,
three
new
complexes
were
synthesized.
Reaction
bidentate
NHC‐ligand,
viz
.
1‐methyl‐3‐(2′‐pyridyl)imidazole
IMe
CN
afforded
[Ru(dipic)(
)(PPh
).
Similar
reactions
two
pincer
ligands,
2,6‐bis(1′‐methyl
imidazolyl)pyridine
CNC
and
2,2′;6′,2“‐terpyridine
trpy
respectively
yielded
B
Structure
optimized
by
DFT
method.
Structures
determined
X‐ray
crystallography.
In
both
3B
the
ligand
found
to
be
N,O‐coordinated
one
carboxy
end
remaining
unbound
metal
center.
Anticancer
property
,
studied
compared.
Cytotoxicity
against
selected
cancer
cell
lines,
chronic
myelogenous
leukemia
line
(K562),
hepatocellular
carcinoma
(HepG2)
breast
adenocarcinoma
(MCF7),
most
promising.
It
displayed
best
activity
K562,
while
it
did
not
have
any
appreciable
effect
on
its
normal
counterpart,
human
peripheral
blood
mononuclear
cells
(hPBMC).
The
comparative
cytotoxicity
studies
indicated
that
presence
C,N,C‐coordinated
NHC
in
together
free
carboxylate
dipic
ligand,
are
presumably
responsible
for
superior
cytotoxic
behavior.
Organometallics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 7, 2024
Coinage
metal
complexes,
particularly
Cu(I)
and
Au(I),
supported
by
N-heterocyclic
carbenes
are
of
broad
interest
in
organometallic
synthesis,
catalysis,
luminescent
materials.
The
d10
coinage
metals
can
adopt
varied
linear,
trigonal
planar,
tetrahedral
geometries.
However,
two-coordinate,
linear
Au(I)
complexes
sterically
demanding
monodentate
or
chelating
generally
observed.
In
most
cases,
ligands
generate
multinuclear
species
with
geometries
at
the
corresponding
centers
rather
than
mononuclear
complexes.
this
report,
we
synthesized
two
bis(carbene)
anchored
a
flexible
bipyridine
rigid
naphthyridine
backbone
tunable
proximal
distal
steric
properties
wingtips
to
examine
influence
rigidity
directionality
carbene
donors
on
formation
planar
species.
bipyridine-bis(carbene)
(ImPy)2
ligand
exclusively
stabilizes
dinuclear
chloride
Ag(I),
whereas
naphthyridine-bis(carbene)
(NBC)
mononuclear,
Ag(I)
complex.
The Journal of Physical Chemistry A,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
DFT
(M06-2X)
calculations
were
used
to
study
the
NHC-catalyzed
[3
+
3]
cycloaddition
of
enals
with
aminoacrylates.
The
catalytic
cycle
begins
binding
NHC
enal.
Subsequent
intramolecular
proton
transfer
generates
Breslow
intermediate.
This
intermediate
undergoes
an
oxidative
reaction,
leading
formation
acyl
azolium
intermediate,
which
further
reacts
other
substrate
aminoacrylate
via
a
new
C–C
bond
formation.
step
determines
stereoselectivity
current
and
re-face
addition
mode
S-configuration
is
predominant.
Afterward,
sequential
protonation,
deprotonation,
cyclization
form
six-membered
cyclic
upon
elimination
affords
final
product
dihydropyridinone.
computed
enantiomeric
excess
(99.1%
ee)
in
very
good
agreement
experimentally
reported
value
(99%
ee).
origin
enantioselectivity
traced
stronger
LP···π
interactions
between
favored
S-congurational
transition
state.
