Platinum group metal (PGM) complexes having acylthiourea ligand system as catalysts or anticancer agents

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215620 - 215620

Published: Jan. 8, 2024

Language: Английский

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A Photodynamic and Photochemotherapeutic Platinum‐Iridium Charge‐Transfer Conjugate for Anticancer Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 24, 2024

The novel hetero-dinuclear complex trans,trans,trans-[Pt

Language: Английский

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A review on the recent advances of interaction studies of anticancer metal-based drugs with therapeutic targets, DNA and RNAs

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 104055 - 104055

Published: June 7, 2024

Language: Английский

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Anti-cancer property and DNA binding interaction of first row transition metal complexes: A decade update

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 116603 - 116603

Published: June 19, 2024

Language: Английский

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In Vitro and In Vivo Anticancer Activities of Water-Soluble Ru(II)(η6-p-cymene) Complexes via Activating Apoptosis Central Regulators and Possibilities of New Antitumor Strategies in Triple Negative Breast Cancers

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

In this study, we synthesized 12 monofunctional tridentate ONS-donor salicylaldimine ligand (L)-based Ru(II) complexes with general formula [(Ru(L)(p-cymene)]+·Cl– (C1-C12), characterized by 1H NMR, 13C UV, FT-IR spectroscopy, HR-ESI mass spectrometry, and single-crystal X-ray analysis showing ligand's orientation around the center. All of these were tested for their anticancer activities in multiple cancer cells. The superior antitumor efficacy C2, C8, C11 was demonstrated reduced mitochondrial membrane potential, impaired proliferative capacity, disrupted redox homeostasis, along enhanced apoptosis through caspase-3 activation downregulation Bcl-2 expression. 4T1 breast orthotopic mouse model, assessment bioluminescence metastatic spread, tumor burden, histopathological evaluation, immunohistochemistry (IHC), hematological profiling tissue Protein expression caspase-3, cleaved TNF-α, bcl-2 that C8 treatment led to prolonged survival suppressed progression triple negative cancer.

Language: Английский

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Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

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Recent Advances in Schiff Base Coinage Metal Complexes as Anticancer Agents: A Comprehensive Review (2021–2025)

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112710 - 112710

Published: Feb. 1, 2025

Language: Английский

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Synthesis and Characterization of a New Neodymium Complex: DFT Insights and Potential Anticancer Applications

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 18, 2025

ABSTRACT A new complex of type [Nd (HL) (NO 3 ) 2 ] has been synthesized with a Schiff base ligand H L derived from 2‐hydroxy‐3‐methoxybenzaldehyde and L‐histidine. The structure the was established using elemental analysis, molar conductivities, FT‐IR, 1 HNMR, SEM, x‐ray diffraction (XRD) spectroscopy. FT‐IR data revealed that acts as tetradentate through carboxylic acid, azomethine nitrogen, methoxy oxygen, hydroxyl groups. Based on electronic spectra, an octahedral configuration hypothesized for complex. TGA method employed to study thermal behavior its complex, thermodynamic parameters were determined Coats–Redfern equations. XRD analysis compounds possess nanoscale dimensions, their crystallinity significantly enhanced by coordination Nd(III) ion L. DFT calculations performed optimize geometry proposed structures, indicating improved stabilities. reduced HOMO–LUMO gap in further highlights remarkable conductive properties. surface morphology analyzed SEM investigate structural characteristics. images reveal variety particle shapes, including elongated, prismatic, irregular blocky particles sharp edges, suggesting crystalline nature. evaluated anticancer activity against prostate carcinoma, breast lung carcinoma cell lines. inhibition rate 92.81%, 93.25%, 94.58%, respectively. results demonstrated exhibited compared alone, likely due These findings suggest holds promise potent agent.

Language: Английский

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Recent Advancements of Aptamers in Cancer Therapy

ACS Omega, Journal Year: 2023, Volume and Issue: 8(36), P. 32231 - 32243

Published: Aug. 30, 2023

Aptamers are chemical antibodies possessing the capability of overcoming limitations posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic applications in cancer. The ease modifications or functionalization, including conjugations with nucleic acids, drug molecules, nanoparticles, has made these aptamers to gain priorities research. In this Mini-review, various reports on therapeutics aptamer-functionalized nanomaterials controlled multistep release, targeted delivery, stimuli-responsive etc. discussed. case nucleic-acid-conjugated aptamers, DNA nanotrains beacons discussed terms possibility multidrug loading chemotherapy gene therapy. Developments electrochemical aptasensors signal-enhanced immune also Further, future scope aptamer technology cancer theranostics prevailing

Language: Английский

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Click-derived multifunctional metal complexes for diverse applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(15), P. 5051 - 5087

Published: Jan. 1, 2023

Numerous complex architectures are possible through Click reactions which display high specificity, flexibility and modularity. chemistry has addressed many challenges in the biomedical field, including drug delivery theranostics.

Language: Английский

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