Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158143 - 158143
Published: Nov. 30, 2024
Language: Английский
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
14
Small Methods, Journal Year: 2024, Volume and Issue: 8(11)
Published: Sept. 25, 2024
Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.
Language: Английский
Citations
6
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7161 - 7181
Published: Feb. 20, 2025
Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.
Language: Английский
Citations
0
ChemPhotoChem, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
The near infrared (NIR) optical window enables to observe biological tissue noninvasively through photoimaging using luminophores. Particularly, the light in NIR II region of 1000–1400 nm between strong absorption bands H 2 O and chromophores is advantageous for phototherapies deep tissue. Pt complexes possessing high emission ability luminescence tunability are expected be luminophores imaging photosensitizers photodynamic therapy. Herein, from designed by strategy extension ligand π conjugation aggregation Pt–Pt interaction recent works reviewed.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216572 - 216572
Published: March 14, 2025
Language: Английский
Citations
0
Inorganics, Journal Year: 2025, Volume and Issue: 13(5), P. 156 - 156
Published: May 8, 2025
Towards the efforts to expand bioactivity and reduce toxic adverse properties of known metal-based drugs, various multinuclear complexes have recently been studied. They shown enhancement target specificity selectivity. Different from small organic compounds traditional with anticancer activity, iridium(III) or heteronuclear metallodrugs confirmed potential advantages due their unique biological chemical diversities, better activity different mechanisms. Ir(III) coordination compounds, similar most Pt group are excessive interest because cytotoxic effective cellular uptake tolerance by healthy cells. Although mononuclear complex extensively studied as promising candidates for antitumor application, research on antineoplastic homo- hetero-multinuclear is not abundant; nevertheless, intensive investigations conducted in recent years towards developing that anticipated improved therapeutic biotarget Multimetallic frameworks offered interesting possibilities designing new agents exploiting action metal cations at same time. This method was very successful design cyclometalated half-sandwich organometallic compounds. In described background, many homonuclear estimated exposed cancer therapy. review intends summarize newly reported innovative Ir(III)-based afford a wide-ranging overview current development perspectives practical impact these tumor therapy field. It this analysis will provide significant direction further progress active iridium-based agents.
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(15), P. 13435 - 13445
Published: July 30, 2024
Photodynamic therapy has been regarded as a noninvasive treatment for cancer with spatiotemporal control over drug activation. Bis-terpyridyl Ru(II) complexes exhibit promising achiral structure but suffer from low photoreactivity due to deviation the ideal octahedral geometry. Herein, we introduce donor–acceptor–donor motif construct dinuclear bis-terpyridyl complex (Ru2). Ru2 exhibits superior light absorption properties compared mononuclear Ru1. Importantly, upon 595 nm excitation, shows synergetic type I/II photosensitization and photocatalytic activity, while Ru1 is inactive. Anticancer mechanistic studies reflect that induces intracellular redox imbalance affects biosynthetic metabolic processes, leading cell apoptosis. Overall, this work provides simple strategy rouse PDT efficiency of complexes.
Language: Английский
Citations
2
ChemMedChem, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 4, 2024
Abstract Photo‐induced chemotherapy offers the best option for selective treatment of cancer among all prevailing modalities. Iridium (III) complexes, flourished with excellent photophysical and photochemical properties, have been considered to be superior undergoing photo‐responsive therapy. Large Stokes shift, long‐lived triplet excited state, photostability, tuneable emission rendered its excellence as a phototheranostic agent. In particular, cyclometalated Ir complexes their respective nanoparticles made strong niche in arena recent years, based shown promising utilities both imaging therapeutic agents well. Therefore, this review summarises advances strategic designing Ir(III) augment applications precision medicine.
Language: Английский
Citations
1
Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 14, 2024
ABSTRACT We developed a novel hetero‐bimetallic Fe(III)‐Mn(I) complex by combining hydroxyl radicals generating Fe(III)‐Phenolato/Carboxylato and CO‐releasing Mn(I)(CO) 3 complexes to achieve dual‐modality theranostic tool for photoactivated anticancer therapy. were conjugated through the amide coupling synthesize bimetallic ( [Fe‐Mn] ) characterized analytically spectroscopically. Various photophysical assays have confirmed production of release CO when biologically benign [ Fe‐Mn ] is activated visible light (400–700 nm), resulting in significant increase luminescence intensity. The cytotoxic potential complex, resulted from enrichment ROS A549 cells with photoindex ~35 leaving HPL1D unaffected. probed caspase 3/7‐dependent apoptosis on photoactivation vitro. ([ Fe‐Mn] provides an ideal example next‐generation
Language: Английский
Citations
1
Scientia Sinica Chimica, Journal Year: 2024, Volume and Issue: 54(9), P. 1522 - 1533
Published: June 20, 2024
光动力疗法(PDT)利用光激活光敏剂(PSs)产生治疗肿瘤的有毒物质,因其特定的时空选择性、无创性以及不易产生耐药性等优点,现已成为癌症治疗的新兴解决方案。近年来,铱(III)配合物因其优异的光物理、光化学和光生物学特性而作为光敏剂引起了广泛关注。本文对铱(III)配合物在光动力治疗肿瘤方面的研究进展进行综述,主要介绍了应用于单/双光子光动力治疗以及基于纳米复合体系设计的铱(III)光敏剂,为开发新型金属抗肿瘤药物提供参考。另外,还总结了近年来铱(III)配合物在光动力免疫抗肿瘤方面的研究,为发展精准高效治疗肿瘤提供一种新的策略。最后,对铱(III)光敏剂在抗癌应用上的前景进行了展望。
Citations
0