Luminescence,
Journal Year:
2024,
Volume and Issue:
39(9)
Published: Sept. 1, 2024
Abstract
Near‐infrared
(NIR)
fluorescent
probes
with
aggregation‐induced
emission
(AIE)
properties
are
of
great
significance
in
cell
imaging
and
cancer
therapy.
However,
the
complexity
its
synthesis,
poor
photostabilities,
expensive
raw
materials
still
pose
some
obstacles
to
their
practical
application.
This
study
reported
an
AIE
luminescent
material
red
application
vitro
photodynamic
therapy
(PDT)
study.
has
characteristics
simple
large
Stokes
shift,
good
excellent
lipid
droplets‐specific
testing
ability.
Interestingly,
this
red‐emitting
can
effectively
produce
reactive
oxygen
species
(ROS)
under
white
light
irradiation,
further
achieving
PDT‐mediated
killing
cells.
In
conclusion,
demonstrates
a
approach
synthesize
NIR
both
therapeutic
effects,
providing
ideal
architecture
for
constructing
long‐wavelength
materials.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Abstract
Lipid
droplets
(LDs)
are
dynamic
intracellular
organelles
that
participate
in
a
wide
range
of
physiological
and
pathological
processes.
Consequently,
the
development
high‐selectivity
high‐resolution
tools
for
LD
detection
tracking
is
paramount
importance.
In
this
study,
we
describe
straightforward
synthesis
series
novel
BODIPY
analogs,
BOQHYs
3a
–
3e
,
through
condensation
2,3‐dihydrazinylquinoline
with
acetone
or
benzophenone,
followed
by
complexation
BF
3
·OEt
2
.
Spectroscopic
properties
indicate
these
dyes
exhibited
significantly
larger
Stokes
shifts
(>100
nm)
than
commercial
LD‐Tracker
493/503
(≈10
nm).
Additionally,
incorporation
phenyl
“rotors”
endows
3b
heightened
aggregation‐induced
emission
activity,
viscosity
responsiveness,
exceptional
lipophilicity,
enabling
their
selective
staining
LDs
rapid
wash‐free
manner,
outstanding
signal‐to‐noise
ratios.
Time‐resolved
confocal
fluorescence
imaging
3d
further
validates
dyes’
capability
to
effectively
capture
fusion
fission
events,
highlighting
potential
applications
LD‐related
cell
biology
disease
diagnostics.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(31), P. 12908 - 12915
Published: July 27, 2024
To
coordinate
cellular
physiology,
cells
rely
on
the
rapid
exchange
of
molecules
at
specialized
organelle–organelle
contact
sites.
Lipid
droplets
(LDs)
and
nuclear
membrane
(NM)
sites
are
particularly
vital
communication
hubs,
playing
key
roles
in
signaling
molecules,
lipids,
metabolites.
However,
there
is
still
a
lack
understanding
specific
morphology
Here,
we
combine
advanced
three-dimensional
(3D)
imaging
with
high-brightness
fluorescent
probe
specifically
targeting
LDs
to
map
structural
landscape
LD–NM
The
exhibits
exceptional
photophysical
properties,
making
it
highly
suitable
for
visualizing
changes
occurring
during
apoptosis
process.
In
addition,
utilize
advantages
accurately
monitor
overexpression
abnormal
cirrhosis
by
3D
first
time.
outcomes
this
investigation
highlight
that
has
potential
as
robust
tool
investigate
intricate
biological
functions
their
implications
related
diseases.
ChemBioChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
The
impacts
of
dimethylation
4-Amino-1,8-Naphthalimide
(ANI)
on
its
photophysical
properties
are
reported.
resulting
4-DiMe-ANI
displays
completely
different
fluorescence
properties,
conferring
it
ability
to
selectively
label
lipid
droplets
in
living
cells.
A
comprehensive
study
revealed
that
this
selectivity
arises
from
an
Internal
Charge
Transfer
favored
lipophilic
media
the
detriment
a
non-emissive
TICT
more
polar
media.
This
results
very
high
"LDs/Cytosol"
signal
ratio,
enabling
LDs
be
imaged
with
excellent
signal-to-noise
and
positioning
performance
above
BODIPY
493/503
commonly
used
image
LDs.
