Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy DOI Creative Commons

Meijia Huang,

Jie Cui,

Qi Wu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir–C–C–Ir Ir–S–S–Ir, which possess aggregation-induced emission (AIE). Ir–S–S–Ir was constructed GSH consumption by introducing a disulfide linkage between auxiliary ligands with imine units. Quantum chemical calculations revealed degenerate states, provide more channels singlet-to-triplet exciton transitions, then intersystem crossing rate increased due heavy atom effect sulfur atoms. production experiments indicated singlet yield 33 times than ACQ mononuclear complex Ir–C. Most importantly, consumed through thiol–disulfide exchange reaction, as demonstrated mass spectrometry high-performance liquid chromatography. Cell testified consumes cells, possesses good capacity, exhibits an extraordinary PDT effect. This first AIE GSH-consuming function.

Language: Английский

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window DOI
Baisong Chang, Jie Chen,

Jiasheng Bao

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

Citations

48
Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications DOI Creative Commons
Dongdong Xu, Yang Li, Shouchun Yin

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 3167 - 3204

Published: Jan. 1, 2024

We report strategies employed by metallacycle/metallacage-based supramolecular coordination complexes to enhance water solubility and biostability reduce potential toxicity side effects for biomedical applications.

Language: Английский

Citations

28
Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer DOI
Ming Jiang, Xiaoling Su,

Xuwei Zhong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139403 - 139403

Published: July 22, 2024

Language: Английский

Citations

9
Bi-anthracene based ruthenium and iridium metalla-rectangles: Coordination driven self-assembly and anti-cancer activities DOI
Gajendra Gupta, Paritosh Patel, Junseong Lee

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113916 - 113916

Published: Jan. 1, 2025

Language: Английский

Citations

1
A hetero-bimetallic Ru(ii)–Ir(iii) photosensitizer for effective cancer photodynamic therapy under hypoxia DOI

Mengsi Zheng,

Xinlin Lin, Kai Xiong

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(20), P. 2776 - 2779

Published: Jan. 1, 2024

A hetero-bimetallic Ru( ii )–Ir( iii ) complex Ru-Ir was developed to act as a type-I and type-II dual photosensitizer for effective cancer photodynamic therapy under hypoxia.

Language: Английский

Citations

6
Self‐Assembled Metal Complexes in Biomedical Research DOI

Wenting Wang,

Yang Xu, Yuqi Tang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Cisplatin is widely used in clinical cancer treatment; however, its application often hindered by severe side effects, particularly inherent or acquired resistance of target cells. To address these challenges, an effective strategy to modify the metal core complex and introduce alternative coordination modes valence states, leading development a series complexes, such as platinum (IV) prodrugs cyclometalated complexes. Recent advances nanotechnology have facilitated multifunctional nanomaterials that can selectively deliver drugs tumor cells, thereby overcoming pharmacological limitations metal‐based drugs. This review first explores self‐assembly complexes into spherical, linear, irregular nanoparticles context biomedical applications. The mechanisms underlying are subsequently analyzed, followed discussion their applications fields, including detection, imaging, antitumor research.

Language: Английский

Citations

5
Shikonin‐Cu(II) Supramolecular Polymers Exhibit Antitumor Activity via Necrosis and Cuproptosis DOI Open Access
Hongyang Zhang, Rui‐Hong Gong, Yi‐An Lin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Supramolecular polymers driven by the metal-ligand coordination possess reversible bonds, making them promising candidates for integrating therapeutic functions of metal ions and small-molecule drugs, subsequently releasing these components within cells after endocytosis. In this study, a kind supramolecular polymer, SHICU, is developed, composed Shikonin ligand Cu(II) ion. Upon reduction intracellular glutathione (GSH), SHICU dissociates to release Shikonin, Cu(II), fragments. The released exhibit synergistic antitumor effect through reactive oxygen species (ROS)-dependent necrosis. Meanwhile, that remains structural integrity induces distinct mechanism triggering cuproptosis in tumor cells. This dual functionality, combining ROS-dependent necrosis cuproptosis, highlights potential advancing therapies, while integration with emerging cell death facilitates development innovative cancer drugs.

Language: Английский

Citations

0
Mixed‐Valence Coordination Strategy Creating Ordered Ternary Ultrasmall Homo‐/Hetero‐structures Driven by Lattice Match for Advanced Photochromism and Encryption Applications DOI Open Access

Yalan Lin,

B.Y. Huang,

Yixie Chen

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Overcoming the challenges of integrating disparate components in nanoarchitectures, this study introduces a straightforward strategy based on mixed‐valence coordination approach, creating an ordered ternary heterostructure integrated with ultrasmall homojunction. This singular homojunction‐heterostructure unites ultrathin 1D rutile TiO 2 nanowires (NWs) and anatase NWs 0D Prussian Blue Analogs (PBAs) nanoparticles (NPs), all exhibiting crystallographic oriented alignment each other, forming mesocrystals. Experimental theoretical insights disclose that complex interplay between these dissimilar is governed by spontaneous lattice match effect, which not only optimizes but also directs charge transfer, thereby enhancing both efficiency stability. It allows for tailoring valence states Fe within PBA, fine‐tuning composite's photochromic properties, introducing abundant defect structures foster strong interaction oxygen molecules, enabling controllable color‐switching dynamics. Consequently, II 1−x III x ‐PBA/TiO exhibits optimized structure R‐TiO /A‐TiO /PBA, demonstrating exceptional photoelectronic significantly photochromism secure encryption capabilities. These establish solid foundation engineering sophisticated complex‐ordered advancing sustainable energy environmental technologies.

Language: Английский

Citations

0
Oligonuclear Manganese Complexes with Multiple Redox Properties for High-Contrast Electrochromism DOI Creative Commons
Yiting Wu, Haotian Deng, Liyi Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 2054 - 2054

Published: May 5, 2025

This study is dedicated to the design of multiple redox-active oligonuclear manganese complexes supported with a bis(tetradentate) ligand (TPDP = 1,3-bis(bis(2-pyridinylmethyl)amino)-2-propanol) for high-contrast electrochromism based on reversible redox process between Mn(II) (colorless) and Mn(III) (dark brown). Pentanuclear Mn5 complex 1 was synthesized via one-pot reaction Mn2+ TPDP, while tetranuclear Mn4 2 (brown) obtained through aerial oxidation 1. features central MnCl6 unit connected two Mn2(μ-TPDP) fragments μ3-Cl− μ-Cl−, whereas adopts symmetric structure mixed-valence Mn2II,III(μ-TPDP)(μ-Cl) that are further linked by μ-oxo. Electrochemical studies revealed multi-step properties both complexes, attributed MnII/MnIII processes significant electronic coupling (ΔE1/2 0.27–0.37 V) Mn centers. Spectroelectrochemical analysis dynamic optical modulation tunable d-d transition ligand-to-metal charge transfer (LMCT) state ⇆ interconversion. The fabricated electrochromic device (ECD) exhibited high contrast colored brown) bleaching (colorless). results highlight potential polynuclear as materials next-generation smart windows adaptive technologies.

Language: Английский

Citations

0
Homo- and Hetero-Multinuclear Iridium(III) Complexes with Cytotoxic Activity DOI Creative Commons
Irena Kostova

Inorganics, Journal Year: 2025, Volume and Issue: 13(5), P. 156 - 156

Published: May 8, 2025

Towards the efforts to expand bioactivity and reduce toxic adverse properties of known metal-based drugs, various multinuclear complexes have recently been studied. They shown enhancement target specificity selectivity. Different from small organic compounds traditional with anticancer activity, iridium(III) or heteronuclear metallodrugs confirmed potential advantages due their unique biological chemical diversities, better activity different mechanisms. Ir(III) coordination compounds, similar most Pt group are excessive interest because cytotoxic effective cellular uptake tolerance by healthy cells. Although mononuclear complex extensively studied as promising candidates for antitumor application, research on antineoplastic homo- hetero-multinuclear is not abundant; nevertheless, intensive investigations conducted in recent years towards developing that anticipated improved therapeutic biotarget Multimetallic frameworks offered interesting possibilities designing new agents exploiting action metal cations at same time. This method was very successful design cyclometalated half-sandwich organometallic compounds. In described background, many homonuclear estimated exposed cancer therapy. review intends summarize newly reported innovative Ir(III)-based afford a wide-ranging overview current development perspectives practical impact these tumor therapy field. It this analysis will provide significant direction further progress active iridium-based agents.

Language: Английский

Citations

0