Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 19, 2024
The
substantial
mortality
and
morbidity
of
hepatocellular
carcinoma,
representing
90%
liver
cancers,
poses
a
significant
health
burden.
effectiveness
traditional
carcinoma
treatments
such
as
surgical
resection,
radiotherapy,
chemotherapy
is
limited,
underscoring
the
need
for
innovative
therapeutic
strategies.
To
this
end,
we
synthesized
phthalyl-pullulan
nanoparticles
encapsulating
IR780
(an
NIR-responsive
heptamethine
cyanine
dye)
R848
(resiquimod;
TLR7/8
agonist)
(PIR
NPs).
Characterization
confirmed
size
loading
capacity
PIR
NPs,
controlled
release
therefrom
upon
NIR
irradiation,
thereby
establishing
potential
versatile
tool.
NPs
were
readily
taken
up
by
Hepa
1-6
cells
in
vitro
targeting
asialoglycoprotein
receptors
present
on
its
cellular
surface.
In
vivo
experiments
combining
photothermal
therapy
immunotherapy,
following
local
near-infrared
accumulated
tumor
sites
induced
immunogenic
cell
death
activated
tumor-specific
T-cell
immune
response,
thus
highlighting
their
potent
antitumor
efficacy.
combined
efficacy
immunotherapy
presents
promising
avenue
addressing
shortcomings
interventions.
This
study
contributes
valuable
insights
into
development
more
effective
targeted
approaches
treatment.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
As
many
treatments
kill
tumor
cells
by
inducing
apoptosis,
fluorescent
probes
that
can
detect
apoptosis
are
crucial
for
effective
feedback
regarding
therapy
outcomes
(in
particular,
activatable
better
imaging).
Cathepsins
enzymes
released
from
lysosomes
into
the
cytoplasm
during
lysosomal
membrane
permeabilization-induced
of
cells,
making
them
potential
biomarkers
apoptotic
cells.
Despite
their
potential,
to
best
our
knowledge,
no
cathepsin-activatable
have
been
reported
this
purpose.
To
fill
gap,
we
designed
a
cathepsin
B
(CTSB)-activatable
probe,
A-DCO,
which
distinguish
normal
in
free
state
and
give
enhanced
fluorescence
signal
under
drug
stimulation
when
encapsulated
nanoparticles
(NPs),
enabling
evaluation
treatment
efficacy.
proof
concept,
A-DCO
NPs
were
employed
rather
than
Annexin-V/PI
double
staining
4T1
MCF-7
via
flow
cytometry.
In
vivo
experiments
demonstrated
rapidly
quickly
metabolized
after
imaging,
achieving
timely,
accurate,
safe
about
effectiveness.
The
study
offers
new
tool
detecting
certain
provides
inspiration
direction
probe
design
future.
Near-infrared
(NIR)
light-mediated
photothermal
and
photodynamic
therapies
are
promising
for
nonsurgical
treatment
of
skin
diseases.
However,
the
skin's
inherent
light
absorption,
especially
from
melanin
in
epidermis,
attenuates
NIR
energy
penetration,
limiting
efficacy
potentially
causing
off-target
tissue
damage.
In
this
context,
we
developed
subcutaneous
response-enhanced
microneedles
(SLE
MNs)
that
allow
basal
layer-localized
seeding
therapeutics
leverage
physical
channels
to
efficiently
transmit
transdermally,
facilitating
situ
scattered
activation
enhanced
therapy
outcomes.
Such
ultraoptical
SLE
MNs
facilitated
achieving
up
80%
initial
power
at
500
μm
subcutaneously,
representing
an
approximate
160%
increase
compared
control
groups.
Additionally,
conceptualized
a
two-segmented
MN
structure
integrating
light-guiding
with
photoresponsive
enable
precise
basal-layer
treatment,
effectively
mitigating
local
hyperenergy
on
surface
attenuation
within
tissues.
This
optical
patch
offers
transformative
platform
transdermal
significant
clinical
potential.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Highly
emissive
metallacages
that
generate
reactive
oxygen
species
(ROS)
are
important
to
synergistic
cancer
therapy,
but
it
is
still
challenging
balance
the
emission
and
phototheranostic
properties.
Herein,
a
metallacage
of
DTPABT-Mc
prepared.
It
observed
in
near-infrared
region
from
600
1000
nm
with
high
photoluminescence
quantum
yield
value
7.92%
solids
recorded
for
DTPABT-Mc.
In
addition,
ability
produce
both
type
I
II
ROS
under
light
irradiation
also
observed,
leading
potential
application
photodynamic
therapy
(PDT)
chemotherapy.
After
that,
4T1@DTPABT-Mc-NPs,
covering
nanoparticles
4T1
cell
membranes,
prepared
enhance
their
tumor-targeting
ability.
This
finally
results
effective
therapeutic
performance
vivo,
effectively
inhibiting
tumor
growth.
These
suggest
DTPABT-Mc-NPs
exhibit
excellent
effects
by
combining
PDT
chemotherapy,
providing
new
ideas
design
agents
diagnosis
future.
