Copper in colorectal cancer patients: a systematic review and meta-analysis

Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but results are contradictory. This study aimed to conduct a systematic review and meta-analysis investigate measured in two biological matrices (serum/plasma/blood tissue) dietary intake CRC patients compared healthy controls. We conducted comprehensive search PubMed, Scopus, Embase Web of Science. included that reported levels serum/plasma/blood, tissue or from diet, with observational design (cohort case-control studies). Study quality was assessed Newcastle-Ottawa scale potential causes heterogeneity were evaluated. Standardized mean differences (SMD) 95% confidence interval (CI) pooled using random-effect models. Overall Odds Ratio CI for risk calculated. Twenty-six (23 3 cohort studies) total 227,354 participants included. Most presented low (50%) moderate (42.3%). No serum/plasma/blood (SMD=0.23; 95%CI -0.23, 0.70; I2=97.3%, 19 studies), (SMD=-1.69; -3.41, 0.03; I2=85.6%, 2 copper/zinc ratio (SMD=1.19; 0.54, 1.84; I2=95.3%, 6 found Regarding copper, had lower (SMD=-0.27; -0.51, -0.03; I2=0.0%, However, evidence shows mostly quality, heterogeneous. More prospective an adequate methodological approach needed.

Language: Английский

---

Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis

iScience, Journal Year: 2024, Volume and Issue: 27(8), P. 110496 - 110496

Published: July 14, 2024

Language: Английский

---

Modulation of Metal Homeostasis for Cancer Therapy

ChemPlusChem, Journal Year: 2024, Volume and Issue: 89(6)

Published: Feb. 7, 2024

Metal ions such as iron, zinc, copper, manganese, and calcium are essential for normal cellular processes, including DNA synthesis, enzyme activity, signaling, oxidative stress regulation. When the balance of metal homeostasis is disrupted, it can lead to various pathological conditions, cancer. Thus, understanding role in cancer has led development anti-tumor strategies that specifically target imbalance. Up now, diverse small molecule-based chelators, ionophores, complexes, metal-based nanomaterials have been developed restore metals or exploit dysregulation therapeutic purposes. They hold great promise inhibiting tumor growth, preventing metastasis, enhancing effectiveness existing therapies. In this review, we aim provide a comprehensive summary employed modulate therapy. Their modulation mechanisms succinctly described, their recent applications field therapy discussed. At end, limitations these approaches addressed, potential avenues future developments explored.

Language: Английский

---

Dendritic Pyridine–Imine Copper Complexes as Metallo-Drugs

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1800 - 1800

Published: April 16, 2024

Since the discovery of cisplatin in 1960s, search for metallo-drugs that are more efficient than platinum complexes with negligible side effects has attracted much interest. Among other metals have been examined potential applications as anticancer agents is copper. The interest copper was recently boosted by cuproptosis, a evidenced form cell death mediated However, also known to induce proliferation cancer cells. In view these contradictory results, there need find most suitable chelators, among which Schiff-based derivatives offer wide range possibilities. Gathering several metal single, larger entity may provide enhanced properties. nanometric objects such purpose dendrimers, precisely engineered hyperbranched macromolecules, outstanding candidates improving therapy and diagnosis. this review article, we present an overview use particular Schiff base, namely pyridine–imine, linked surface complexing copper, dendrimer biology, against cancers.

Language: Английский

---

Cuproptosis in cancers: Function and implications from bench to bedside

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116874 - 116874

Published: June 7, 2024

Copper, an indispensable micronutrient, is implicated in numerous vital biological processes and essential for all physiological activities. Recently, the discovery of a novel type copper-dependent cell death, known as cuproptosis, has shed light on its role cancer development. Extensive research currently underway to unravel mechanisms underlying cuproptosis correlation with various types. In this review, we summarize findings regarding roles types, including colorectal cancer, lung gastric breast liver cutaneous melanoma. Furthermore, effects copper-related agents such copper chelators ionophores proliferation, apoptosis, angiogenesis, tumor immunity, chemotherapy resistance have been explored preclinical clinical trials. These insights provide promising avenues development prospective anticancer drugs aimed at inducing cuproptosis.

Language: Английский

---

Recent advances in copper homeostasis-involved tumor theranostics

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100948 - 100948

Published: Sept. 7, 2024

As the third essential trace element in human body, copper plays a crucial role various physiological processes, which lays foundation for its broad applications cancer treatments. The overview of copper, including pharmacokinetics, signaling pathways, and homeostasis dysregulation, is hereby discussed. Additionally, cuproptosis, as newly proposed cell death mechanism associated with accumulation, analyzed further developed efficient treatment. Different forms Cu-based nanoparticles their advantages, well limiting factors, are introduced. Moreover, unique characteristics give rise to imaging modalities. In addition, nanomaterials featured by excellent photothermal property ROS-associated tumor-killing potential, widely explored diverse therapies combined therapies. Reducing concentration Cu

Language: Английский

---

Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Breast cancer is the most commonly diagnosed worldwide. Metal metabolism pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron copper are essential metal ions critical maintaining cellular function. The accumulation of iron triggers distinct death pathways, known as ferroptosis cuproptosis, respectively. Ferroptosis characterized by iron-dependent lipid peroxidation, while cuproptosis involves copper-induced oxidative stress. They increasingly recognized promising targets development anticancer drugs. Recently, compelling evidence demonstrated that interplay between plays a crucial role progression. This review elucidates converging pathways Moreover, we examined value genes associated with clinical diagnosis treatment cancer, mainly outlining potential co-targeting approach. Lastly, delve into current challenges limitations this strategy. In general, offers an overview interaction offering valuable perspectives further research treatment.

Language: Английский

---

Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 361 - 377

Published: Feb. 12, 2025

Language: Английский

---

Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Cuproptosis is a newly discovered copper‐dependent form of cell death. Intracellular glutathione (GSH) acts as copper chelator to inhibit cuproptosis, so the reduction GSH concentration conducive enhancing cuproptosis cells. In order reduce content and interfere with mitochondrial metabolism, strategy based on calcium overload depletion enhance proposed in this study. Containing manganese (Mn) (Cu) elements, CaCO 3 nanoparticles (NPs) are modified MCF‐7 aptamer (CaCO /Mn/Cu@lip‐Apt). When entering cell, /Mn/Cu@lip‐Apt decomposed released Mn* (Mn 2+ /Mn 3+ 4+ ), Cu Ca . The high valence Mn ion can effectively consume produce which catalyzed H 2 O reactive oxygen species (ROS), while reducing concentration. production ROS promoted influx exogenous large accumulation led intracellular overload, resulting dysfunction metabolism disorders. , turn triggered cuproptosis. This showed excellent antitumor effects provided new way study disease treatment.

Language: Английский

---

Theranostic Rhenium Complexes as Suborganelle-Targeted Copper Ionophores To Stimulate Cuproptosis for Cancer Immunotherapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Being a recently identified mode of programmed cell demise, the functional implications cuproptosis in genesis, progression, and therapeutic modulation cancer remain largely unknown. Given that is predominantly elicited by cellular copper overload, notably attributable to dysregulation homeostasis within mitochondria, we designed series phosphorescent rhenium(I) complexes (Re1-Re5) as suborganelle-targeted ionophores. Among them, Re5 can successfully transport extracellular into mitochondria Golgi apparatus especially enrich mitochondria. Consequently, breaks redox balance disturbs energetic metabolism pathways induce cuproptosis. Finally, prove promote immune responses modulate microenvironments. In all, present here first subcellular organelle-targeted ionophore cuproptosis-inducing small molecules are potent immunotherapeutic candidates.

Language: Английский

---