Co-delivery of carboplatin and doxorubicin using ZIF-8 coated chitosan-poly(N-isopropyl acrylamide) nanoparticles through a dual pH/thermo responsive strategy to breast cancer cells

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131971 - 131971

Published: May 3, 2024

Language: Английский

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Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

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Exploring the antimicrobial and anticancer activities of zinc doped nanohydroxyapatite prepared via ultrasonic-assisted method for bone tissue engineering

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2024, Volume and Issue: 39(13), P. 1911 - 1925

Published: May 14, 2024

Language: Английский

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Integration of STING activation and COX-2 inhibition via steric-hindrance effect tuned nanoreactors for cancer chemoimmunotherapy

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122695 - 122695

Published: June 29, 2024

Language: Английский

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Flying‐Saucer‐Shaped Nanoheterojunctions with Enhanced Colorectal Tumor Accumulation for Increased Oxidative Stress and Immunometabolic Regulation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions coating copper oxide (Cu x O) onto surface PEGylated zinc (ZnO) nanoparticles constructed. When exposed to ultrasound, resultant Cu O@ZnO exhibit increased locomotor activities, facilitating mucus infiltration, deep penetration, cell internalization. decoration O suppresses rapid recombination electrons holes promoting production singlet oxygen hydroxyl radical, which generated through a Fenton‐like chemodynamic reaction sonodynamic reaction. After rectal administration, sono‐chemodynamic plus PD‐L1 antibodies effectively inhibit growth orthotopic distant tumors. It elicits responses inducing immunogenic death, activating interferon genes signaling pathway stimulator, inhibiting glucose transport glycolytic pathways. This combined modality also increases proportion beneficial microbes ( e.g ., Bifidobacterium ) decreases abundance harmful microorganisms Romboutsia intestine. ultrasound antibodies) is promising strategy for synergistic cancer.

Language: Английский

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Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5171 - 5171

Published: May 9, 2024

Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively biological barriers. Smart designed/tuned nanostructures can be effective for cancer treatment. The selection design of adjustment size surface properties important, especially some precision treatments drug delivery (DD). By designing specific methods, an era opened in biomedical field personalized precise Here, we focus on advances nanostructures, as well how structure shape, size, charge, fluids (BFs) affected. We discussed applications specialized therapy head neck (HNC), which is a difficult aggressive type treat, give impetus novel treatment approaches this field. also comprehensively touched shortcomings, current trends, future perspectives when using cancer.

Language: Английский

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Degradable and Piezoelectric Hollow ZnO Heterostructures for Sonodynamic Therapy and Pro-Death Autophagy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Piezoelectric materials can generate charges and reactive oxygen species (ROS) under external force stimulation for ultrasound-induced sonodynamic therapy (SDT). However, their poor piezoelectricity, fast electron–hole pair recombination rate, biological toxicity of piezoelectric limit the therapeutic effects SDT. In this study, hollow ZnO (HZnO) nanospheres were synthesized by using a one-step method. The structure facilitated deformation HZnO ultrasound mechanical increased constant. Subsequently, black phosphorus quantum dots (BPQDs) arginine-glycine-aspartic acid peptide (RGD)-poly(ethylene glycol) (PEG) combined with to further enhance effect constructing heterojunctions enable tumor-targeting ability. During treatment, HZnO-BPQDs-PEG could degrade in an acidic tumor microenvironment release Zn2+ PO43– ions induce pro-death autophagy. ROS produced SDT also accelerated autophagy promoted ferroptosis cancer cells. This study demonstrates that has strong effectively cells, providing new idea design application therapy.

Language: Английский

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Elucidating Manganese Single‐Atom Doping: Strategies for Fluorescence Enhancement in Water‐Soluble Red‐Emitting Carbon Dots and Applications for FL/MR Dual Mode Imaging

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The absence of the enhancement fluorescence in carbon dots (CDs) through doping with transition metal atoms (TMAs) hinders advancement multi‐modal bio‐imaging CDs high photoluminescence quantum yield (PLQY). Herein, Mn‐atomically‐doped R‐CDs (R‐Mn‐CDs) a PLQY 41.3% water is presented, enabling efficient vivo dual‐mode fluorescence/magnetic resonance (MR) imaging. comprehensive characterizations reveal that incorporation Mn leads to Mn‐N 2 O coordinating structure, resulting five significant effects: an increase sp conjugation domains, reduction band gap, decreased oxidation level, photo‐excited electron numbers, and suppression non‐radiative relaxation pathways. Collectively, these factors contribute remarkable R‐Mn‐CDs. Additionally, also endows R‐Mn‐CDs superior MR imaging capabilities due to, which highlights their promising prospect as dual‐modal platform for fluorescence/MR Furthermore, findings indicate introduction various TMAs, such Mn, Zn, Ni, Cu, can universally improve water‐soluble construction TMAs─O bonds. This research provides valuable theoretical insights into mechanisms underlying induced by TMAs offers guidance future design CDs.

Language: Английский

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The role of energy deposition on the luminescence sensitization in porphyrin functionalized SiO2/ZnO nanoparticles under X-rays excitation

Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators radiation oncology, showing potential to improve therapeutic results compared traditional protocols. In this work, we studied SiO2/ZnO nanoparticles functionalized porphyrin as photosensitizer, capable producing cancer cytotoxic reactive oxygen species possible use radio-oncological therapeutics. Radioluminescence measurements under increasing energy ionizing beam up 10 keV show sensitization moieties on SiO2/ZnO. This can be attributed increase deposition promoted by ZnO nanoparticles, higher density atomic number. assumption was confirmed computational simulations after first interaction SiO2, ZnO, air. Indeed, Monte Carlo evidence that, despite decrease absolute number X-rays interacting within system while beam, at keV, presence is dominant enhance deposition. Hence, these experimental importance each nanosystem component scintillation process. work shows how appropriate choice constituents, terms physicochemical properties architecture, favour mechanisms X-ray irradiation thus boost nanosystems' performance biomedical scintillation-based applications.

Language: Английский

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“Off-on-off”-based metal-organic framework fluorescent sensor for adenosine triphosphate detection and tumor microenvironment-triggered drug release

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1345, P. 343741 - 343741

Published: Jan. 29, 2025

Language: Английский

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