Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(10)
Published: Sept. 5, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(47)
Published: Aug. 16, 2024
Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.
Language: Английский
Citations
17
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 28, 2025
Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive systems (SRDDSs) have shown promising application prospects. Intelligent nano responsive endogenous stimuli such as weak acidity, complex redox characteristics, hypoxia, active energy metabolism, well exogenous like high temperature, light, pressure, magnetic fields are increasingly being applied in chemotherapy, radiotherapy, photothermal therapy, photodynamic various other anticancer approaches. Metal–organic frameworks (MOFs) become candidate materials for constructing SRDDSs due their large surface area, tunable porosity structure, ease synthesis modification, good biocompatibility. This paper reviews MOF-based modes cancer therapy. It summarizes key aspects, including classification, synthesis, modifications, loading modes, stimuli-responsive mechanisms, roles different modalities. Furthermore, we address current challenges summarize potential applications artificial intelligence MOF synthesis. Finally, propose strategies enhance efficacy safety SRDDSs, ultimately aiming at facilitating clinical translation.
Language: Английский
Citations
2
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 38, P. 101177 - 101177
Published: May 1, 2024
Language: Английский
Citations
15
Bioresource Technology, Journal Year: 2024, Volume and Issue: 406, P. 131072 - 131072
Published: July 4, 2024
Language: Английский
Citations
15
Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 163 - 190
Published: May 21, 2024
Oral administration is the most simple, noninvasive, convenient treatment. With increasing demands on targeted drug delivery, traditional oral treatment now facing some challenges: 1) biologics how to implement and ensure bioavailability not lower than subcutaneous injections; 2) How achieve therapy of drugs in gastrointestinal tract? Based these two issues, delivery microrobots have shown great application prospect due their characteristics flexible locomotion or driven ability. Therefore, this paper summarizes various developed recent years divides them into four categories according different driving modes: magnetic-controlled microrobots, anchored self-propelled biohybrid microrobots. As involve disciplines such as materials science, mechanical engineering, medicine, control systems, begins by introducing barriers that must overcome. Subsequently, it provides an overview typical involved design process To enhance readers' understanding working principles we present a guideline for designing Furthermore, current development status types reviewed, summarizing respective advantages limitations. Finally, considering significant concerns regarding safety clinical translation, discuss challenges prospections translation presented paper, providing corresponding suggestions addressing existing challenges.
Language: Английский
Citations
12
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124099 - 124099
Published: April 16, 2024
Language: Английский
Citations
11
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136321 - 136321
Published: Feb. 1, 2025
Language: Английский
Citations
1
Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102177 - 102177
Published: March 1, 2025
Language: Английский
Citations
1
Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100951 - 100951
Published: Aug. 23, 2024
Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.
Language: Английский
Citations
8
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1307, P. 137927 - 137927
Published: March 1, 2024
Language: Английский
Citations
5