Applications and advantages of MOFs-based triboelectric nanogenerators for self-powered system

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216708 - 216708

Published: April 14, 2025

Language: Английский

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Sustainable celloMOF cargoes for regenerative medicine and drug delivery therapies: A review

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 212, P. 118293 - 118293

Published: March 7, 2024

Language: Английский

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Investigating the Size Effect of Metal–Organic Frameworks in Drug Delivery and Anticancer Properties

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Here, we show particle size-dependent therapeutic efficacy with a Zn-based metal-organic framework (MOF). The size of MOFs was tuned in specific ranges (∼100, 200, and 300 nm) built upon the manipulation synthetic conditions. X-ray photoelectron spectroscopy, infrared, PXRD, dynamic light scattering scanning electron microscopy analyses were used to identify synthesized structures. various revealed minimal changes molecular properties these structures regardless their size, confirming our hypothesis regarding preservation identity MOF nanoparticles despite variation. carriers undergo structure relative destruction response weak acidic tumor microenvironment, this degradation allows release Nimesulide drug into environment. Interestingly, anticancer studies resulting SKBR3 (Human breast cancer cell) cells indicate that different sizes resulted inhibition capacities against cells. This work shows importance optimizing geometry carrier, such as shape, achieve highest cellular uptake performance. Besides, theoretical carried out using B3LYP/6-31G (d,p) density functional theory methods more consider adsorption mechanism.

Language: Английский

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Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 1, 2024

Abstract Background Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological treatments for improving remain unsatisfactory. The induction of endothelial autophagy and elimination reactive oxygen species (ROS) represent potential therapeutic targets enhancing angiogenesis facilitating formation. This study investigates molybdenum disulfide nanodots (MoS NDs) prognosis. Results Our shows that MoS NDs significantly enhance ischemic tissues diabetic mice, effective blood resupply. Additionally, boost proliferation, migration, tube cells under high glucose/hypoxia conditions vitro. Mechanistically, beneficial effects on not only depend their known scavenging properties ROS (H O , •O - •OH) but also primarily involve molecular pathway, cAMP/PKA-NR4A2, which promotes contributes mitigating damage cells. Conclusions Overall, this investigated specific mechanism by mediated activation highlighted synergy between antioxidation, thus suggesting an economic biocompatible nano-agent dual functions highly preferable promoting context, thus, highlighting potential. Graphical

Language: Английский

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Colorimetric immunoassay of furazolidone metabolites based on iron-copper bimetallic organic framework nanoenzyme

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(10)

Published: Sept. 5, 2024

Language: Английский

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