Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122610 - 122610

Published: May 11, 2024

Language: Английский

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Photodynamic therapy with photodegradable photosensitizers

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Photodegradable photosensitizers minimize post-treatment side effects and improving the overall safety profile of photodynamic therapy.

Language: Английский

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A novel imidazolium functionalized tetraphenylethane for ATP detection and photoinduced ROS generation

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112720 - 112720

Published: Feb. 1, 2025

Language: Английский

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Nonlight-Driven Aggregation-Induced Emission Luminogens for Bioimaging and Theranostics

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Aggregation-induced emission luminogens (AIEgens) have been prosperously developed and applied in the fields of optical imaging theranostics since its establishment. Nowadays, AIEgens can fulfill nearly all requirements with spectra ranging from visible to near-infrared wavelengths. Although a variety varying wavelengths functionalities continuously designed, their performance is heavily dependent on use conventional light sources, such as xenon lamps lasers, which severely hinder further applications due limited penetration depth background autofluorescence biological tissues. To mitigate these limitations maximize potential AIEgens, unconventional excitation sources chemical energy, ultrasound, X-ray offer effective alternatives that circumvent drawbacks associated traditional light-based constant excitation. In this Review, we introduce fundamental principles governing combination highlight recent advancements using excited by for bioimaging theranostics, discuss current challenges future perspectives aimed at advancing biomedical AIEgens.

Language: Английский

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提高光敏剂代谢或降解能力的分子策略（特邀）

Chinese Journal of Lasers, Journal Year: 2025, Volume and Issue: 52(3), P. 0307203 - 0307203

Published: Jan. 1, 2025

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Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

ABSTRACT Alzheimer's disease (AD) is one of the most prevalent forms neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) recognized to play an essential role in pathophysiology AD. The Aβ species are known exist various forms, including soluble monomers, oligomers, and insoluble aggregates. Despite extensive efforts regulate aggregation, no successful medications have been developed date. Among strategies for AD treatment, phototherapy, photodynamic therapy (PDT), photothermal (PTT), photopharmacology, photobiomodulation (PBM) attracted increased attention because spatiotemporal controllability. Representative examples PDT, PTT, PBM discussed terms inhibitory mechanism, unique properties materials, design phototherapy modulators. major challenges against addressed promising prospects proposed. It concluded that noninvasive light‐assisted approaches will become a strategy intensifying modulation aggregation or promoting clearance thus facilitating treatment.

Language: Английский

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NIR light-triggered photodynamic antibacterial nanofiber membrane based on polycaprolactone and phthalocyanine derivative for biomedical applications

RSC Advances, Journal Year: 2024, Volume and Issue: 14(34), P. 24424 - 24437

Published: Jan. 1, 2024

NIR light triggered photodynamic antibacterial nanofiber membrane based on phthalocyanine derivative for biomedical applications.

Language: Английский

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Russell Mechanism‐Mediated Cancer Therapy: A Minireview

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(14)

Published: April 17, 2024

The Russell mechanism, proposed by Russell, is a cyclic mechanism for the formation of linear tetroxide intermediates, which can spontaneously produce cytotoxic singlet oxygen (

Language: Английский

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Synthesis of Coumarin-Based Photosensitizers for Enhanced Antibacterial Type I/II Photodynamic Therapy

Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3793 - 3793

Published: Aug. 10, 2024

Photodynamic therapy (PDT) is an effective method for treating microbial infections by leveraging the unique photophysical properties of photosensitizing agents, but issues such as fluorescence quenching and restricted generation reactive oxygen species (ROS) under hypoxic conditions still remain. In this study, we successfully synthesized designed a coumarin-based aggregation-induced emission luminogen (AIEgen), called ICM, that shows remarkable capacity type I ROS II generation. The 1O2 yield ICM 0.839. it produces include hydroxyl radicals (HO•) superoxide anions (O2•−), with highly antibacterial specifically targeting Staphylococcus aureus (a Gram-positive bacterium). Furthermore, enables broad-spectrum imaging exhibits excellent biocompatibility. Consequently, potent photosensitizer eliminating pathogenic microorganisms, represents promising tool in addressing threat posed these pathogens.

Language: Английский

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