Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
ABSTRACT
While
nanomedicine
research
shows
a
great
progress
in
the
treatment
of
cancer,
it
still
faces
challenges
tumor
recurrence
and
metastasis.
Numerous
studies
have
demonstrated
intricate
crosstalk
between
platelets
cells.
The
re‐education
by
cells
enables
these
to
provide
critical
assistance
for
proliferation,
recurrence,
Engineered
shown
promising
potential
tumors,
postoperative
Different
engineering
technologies
such
as
surface
modification,
gene
editing,
membrane
coating,
loading
into
hydrogels
can
produce
multifunctional
customized
engineered
platelets.
These
inherit
key
properties
platelets,
including
long
blood
circulation,
targeting,
thrombus
be
stimulated
generate
derivatized
particles.
In
this
review,
we
elucidate
role
complex
processes
tumorigenesis
progression
summarize
emerging
paradigm
therapy.
purpose
review
is
comprehensively
explore
value
toward
clinical
providing
valuable
reference
further
development
their
broader
applications
field
cancer
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
The
emerged
apoptosis/ferroptosis
synergistic
platinum-based
therapy
has
attracted
a
lot
of
attention
but
is
far
from
clinic
use
due
to
high
systemic
toxicity.
Herein,
series
novel
precise
carrier-free
self-assembled
platinum(IV)
nanoparticles
with
lipid
regulation
effect
named
FSPNPs
(5NPs–8NPs)
were
constructed
via
connecting
fenofibrate
acid
(FA)
cisplatin
or
oxaliplatin-derived
platinum(IV)-intermediates
disulfide
bonds.
can
be
stimulated
by
high-glutathione/ascorbic
and
acidity
environment
produce
an
"explosion-like"
cascade
release
process.
Cell-activity
showed
precision
FSPNPs,
which
accumulated
more
in
tumor
cells
inhibited
cell
proliferation.
Especially,
5NPs
have
higher
selectivity
than
cisplatin.
downregulated
glutathione/glutathione
peroxidase
4,
increased
reactive
oxygen
species/lipid
peroxidation/malondialdehyde,
induced
DNA
damage/S-phase
arrest,
regulated
p53/Bcl-2/Bax
trigger
the
hybrid
pathway.
released
FA
derivates
docked
into
peroxisome
proliferator-activated
receptor
α
activating
cholesterol
metabolism
destroy
membrane
integrity.
also
good
biocompatibility
superior
antitumor
activity
no
observable
tissue
damage.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(17), P. 4335 - 4353
Published: Jan. 1, 2024
Reactive
oxygen
species
(ROS)
play
a
dual
role
in
pathology
and
therapy.
ROS-responsive
nanoscale
drug
carriers
offer
promising
strategy
to
leverage
elevated
ROS
levels
diseased
tissues
for
targeted,
enhanced
therapeutic
delivery
efficacy.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
ABSTRACT
While
nanomedicine
research
shows
a
great
progress
in
the
treatment
of
cancer,
it
still
faces
challenges
tumor
recurrence
and
metastasis.
Numerous
studies
have
demonstrated
intricate
crosstalk
between
platelets
cells.
The
re‐education
by
cells
enables
these
to
provide
critical
assistance
for
proliferation,
recurrence,
Engineered
shown
promising
potential
tumors,
postoperative
Different
engineering
technologies
such
as
surface
modification,
gene
editing,
membrane
coating,
loading
into
hydrogels
can
produce
multifunctional
customized
engineered
platelets.
These
inherit
key
properties
platelets,
including
long
blood
circulation,
targeting,
thrombus
be
stimulated
generate
derivatized
particles.
In
this
review,
we
elucidate
role
complex
processes
tumorigenesis
progression
summarize
emerging
paradigm
therapy.
purpose
review
is
comprehensively
explore
value
toward
clinical
providing
valuable
reference
further
development
their
broader
applications
field
cancer
