Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 26, 2024
Abstract
The
availability
of
second
near‐infrared
(NIR‐II)
excitable
two‐photon
photosensitizers
with
NIR‐I
emission
for
efficient
photodynamic
therapy
(PDT)
is
limited
by
challenges
in
molecular
design.
In
this
study,
a
NIR‐II
light‐excitable
conjugated
microporous
polymer
(
Tph‐Dbd
)
the
region
developed.
large
system
and
delocalized
electronic
structures
endow
absorption
cross‐section
under
light
excitation.
Moreover,
electron
acceptor
donor
units
within
π‐conjugated
backbones
result
high
signal‐to‐background
ratio
imaging,
as
well
separated
highest
occupied
orbital
lowest
unoccupied
distributions
excellent
singlet
oxygen
generation
ability.
activity,
emission,
good
biocompatibility,
photostability
allow
to
be
used
vitro
fluorescence
imaging
guided
PDT.
impressive
photothermal
effect
can
overcome
limitations
PDT
treatment
hypoxic
tumors.
This
study
highlights
strategy
designing
advanced
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 23504 - 23512
Published: Oct. 10, 2024
Aggregation-induced
emission
(AIE)-based
photosensitizers
(PSs)
are
well-known
for
their
exceptional
biocompatibility
and
high
irradiation-induced
reactive
oxygen
species
(ROS)
generation
capacity,
making
them
promising
candidates
photodynamic
therapy
(PDT).
In
antitumor
treatment,
enhancing
the
spatiotemporal
specificity
of
AIEgen
PSs
can
maximize
efficacy
suppressing
tumor
cells.
Lysosomes,
as
digestive
cellular
organelles,
be
perturbed
by
various
external
stimuli,
leading
to
dysfunction
even
apoptosis.
This
makes
ideal
targets
effective
precise
PDT.
this
study,
an
AIE
photosensitizer
MEO-TTMN
(MT)
was
encapsulated
with
a
silica
shell
develop
AIE-based
nanoparticles
(NPs),
MT@SiO2-MP
NPs,
The
absorption
peaks
these
NPs
were
at
513
675
nm,
respectively.
Upon
irradiation,
exhibited
stronger
ROS
capacity
when
compared
commercial
chlorin
e6
(Ce6).
decoration
morpholine
group
on
surface
facilitated
accumulate
specifically
in
lysosomes.
A
level
proven
situ
generated
lysosomal
sites
which
led
damage
lysosomes
subsequent
apoptosis
vivo
PDT
tumor-bearing
mouse
demonstrated
that
significantly
suppressed
growth
tumor.
work
has
provided
efficient
lysosome-targeting
improve
accuracy,
is
beneficial
cancer
field
nanomedicine
research.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 20, 2024
The
healing
of
infected
wounds
is
challenging
for
patients.
In
this
paper,
a
hybrid
hydrogel
with
strong
tissue
adhesion,
self-healing,
and
antibiosis
without
antibiotics
was
developed
as
dressing
to
promote
the
chronic
wounds.
Acrylamide
(PAM)
polymerized
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(21), P. 13341 - 13349
Published: Oct. 29, 2024
Skin
is
the
initial
defense
against
infection
of
body
but
becomes
vulnerable
when
damaged.
Subsequent
bacterial
infections
can
cause
more
severe
ulcers.
Antibiotics
are
useful
for
infected
wound
healing
also
speed
up
evolution
antibiotic-resistant
bacteria.
Dressing
and
antibacterial
photodynamic
therapy
(PDT)
effective
methods
protecting
treating
wounds,
respectively.
Herein,
we
developed
a
spray
hydrogel
based
on
sodium
alginate
hydrogels,
loaded
with
methylene
blue
(MB)
closo-dodecaborate
cluster
(closo-B12H122–),
physical
protection
PDT.
Among
them,
MB
acted
as
photosensitizer,
which
produce
reactive
oxygen
species
(ROS)
through
PDT
process
to
implement
therapeutic
effect
toward
bacterial-infected
wounds.
closo-B12H122–
form
supramolecular
photosensitizer
(MB-B12),
reduce
dark
toxicity
without
significantly
affecting
its
effect.
Moreover,
introduction
upgrade
property
better
increase
loading
capacity
healing.
The
demonstrated
an
outstanding
ability
around
99%
Staphylococcus
aureus
95%
Escherichia
coli.
This
PDT-spray
system
be
favorable
option
Materials Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
8(23), P. 3877 - 3897
Published: Jan. 1, 2024
This
paper
reviews
the
potential
of
self-assembled
phthalocyanine-based
nano-photosensitizers
for
overcoming
limitations
photodynamic
therapy
(PDT)
in
treating
hypoxic
tumors.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 26, 2024
Abstract
The
availability
of
second
near‐infrared
(NIR‐II)
excitable
two‐photon
photosensitizers
with
NIR‐I
emission
for
efficient
photodynamic
therapy
(PDT)
is
limited
by
challenges
in
molecular
design.
In
this
study,
a
NIR‐II
light‐excitable
conjugated
microporous
polymer
(
Tph‐Dbd
)
the
region
developed.
large
system
and
delocalized
electronic
structures
endow
absorption
cross‐section
under
light
excitation.
Moreover,
electron
acceptor
donor
units
within
π‐conjugated
backbones
result
high
signal‐to‐background
ratio
imaging,
as
well
separated
highest
occupied
orbital
lowest
unoccupied
distributions
excellent
singlet
oxygen
generation
ability.
activity,
emission,
good
biocompatibility,
photostability
allow
to
be
used
vitro
fluorescence
imaging
guided
PDT.
impressive
photothermal
effect
can
overcome
limitations
PDT
treatment
hypoxic
tumors.
This
study
highlights
strategy
designing
advanced
