Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds DOI
Li Ni, Xiaoyu Zhang,

Jia Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138349 - 138349

Published: Dec. 4, 2024

Language: Английский

Advances in the study of polysaccharide-based hydrogel wound dressings DOI
Yu Zhang, Ning Qiao, Lihua Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

Citations

1
Sapropel-enriched sodium carboxymethyl cellulose gel systems: formulation approaches, stability and bioactive potential DOI Creative Commons
Aneka Kļaviņa, Jeļena Reste, Inese Mārtiņsone

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100669 - 100669

Published: Jan. 1, 2025

Language: Английский

Citations

0
Protein-polysaccharide based nanogel/hydrogel composite with controlled continuous delivery of drug for enhanced wound healing DOI
Yi Mao, Bing Tian Zhao,

Linghui Xu

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123407 - 123407

Published: Feb. 1, 2025

Language: Английский

Citations

0
Development of κ‐Carrageenan/Gelatin pH‐Responsive Hydrogels for Potential Skin Regeneration Application DOI Open Access
Jovana S. Vuković,

Martina Žabčić,

Lea Gazvoda

et al.

Biopolymers, Journal Year: 2025, Volume and Issue: 116(2)

Published: March 1, 2025

ABSTRACT Advanced skin care involves innovative, multifunctional, and bio‐inspired biomaterials capable of regenerating tissue. Here, we report the facile route for fabrication bio‐sourced pH‐responsive hydrogels based on κ‐carrageenan gelatin, with properties desirable treatment versatile disorders. The extensive characterization revealed differences in physicochemical due to chemical modifications hydrogels. Porosity ranged from 21.67% 95.81%. By modifying Young's modulus values increased proportionally gelatin content, ranging 0.23 2.90 MPa, while native had lowest (0.12–0.42 MPa) highest (10.85–18.03 MPa). Native exhibited most pronounced swelling (18.6–27.0), followed by gelatin‐modified (6.5–23.0) (7.8–9.0). also displayed water vapor transmission rate (WVTR) (259.99 ± 16–279.91 19 g m −2 day −1 ), presence lowered it. were preliminary exposed human fibroblasts (MRC‐5 cell line) then Caenorhabditis elegans reveal effects whole living organisms. summarized results suggest that represent advantageous biocompatible set further investigation as delivery platforms bioactive molecules suitable tissue regeneration.

Language: Английский

Citations

0
Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid DOI Creative Commons

J A Romero-Antolín,

Natividad Gómez‐Cerezo, Miguel Manzano

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Poly (Lipoic Acid) Hydrogel Dressings With Adhesion, Self‐Healing, and Self‐Adaptive Properties via Dynamic Bonding DOI Open Access
Zhiyuan Zhang, Yan Wang, Chen Wang

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Self‐healing hydrogels have become a hot research topic in the field of wound care due to their ability prevent secondary damage dressing and reduce risk infection. The aim this study was develop hydrogel network system with excellent self‐healing antimicrobial properties, which is particularly suitable for applications. stability enhanced by forming long chains through lipoic acid (LA) disulfide bonding inhibiting chain depolymerization via polygallic (PGA)‐mediated SAr bonding. In addition, poly(lysine) (PL) doped into electrostatic interactions further enhance structural strength properties hydrogels. This noncovalent gel endowed softness fluidity, enabling them adapt various shapes. Through experimental results, it shown that not only possessed mechanical remarkable ability, but also exhibited good cytocompatibility. Antimicrobial tests more than 99.9% effective against Escherichia coli Staphylococcus aureus . Thus, PLA/PGA/PL self‐healing, antimicrobial, biocompatibility shows great potential application as dressings becomes strong candidate dressings.

Language: Английский

Citations

0
Engineering cuttlefish melanin nanoparticles: A dual-action therapy for acute radiation syndrome and combined radiation-wound injuries via regulating Bcl-2 family proteins and caspases in the apoptotic process DOI

Zhemeng Zhao,

Bin Hu,

Danfeng Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162108 - 162108

Published: March 1, 2025

Language: Английский

Citations

0
An Injectable, Self‐Adaptive Hydrogel with Metallic‐Functionalized Metal Organic Frameworks for Enhanced Wound Healing in Dynamic Infectious and Inflammatory Microenvironment DOI

Yanping Yu,

Ping Li, Lina Bao

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Wound healing is a dynamic process often accompanied by bacterial infection. Bacterial proliferation and induced excessive inflammation hinder the in infectious wounds, leading to refractory wounds. Addressing challenges of wounds requires development multifunctional dressings capable eliminating infection, relieving inflammation, restoring wound microenvironment. In this study, Ag + ‐ion functionalized Cu 2+ UiO‐67 metal‐organic framework (MOF‐Ag MOF‐Cu) are incorporated into an oxidized dextran gelatin mixture fabricate hydrogel, termed as OGAC. The resulting OGAC exhibited injectable, adhesive, hemostatic, antibacterial, anti‐inflammatory properties, along with good biocompatibility. hydrogel precursor could be injected situ at site cover wound, serving physical barrier protect Moreover, demonstrates efficient antibacterial anti‐biofilm activity, against both Escherichia coli Staphylococcus aureus . Additionally, has superoxide dismutase‐like glutathione peroxidase‐like activity for anti‐oxidation, which conducive reduce wound. reveals high performance infected mouse model. These findings suggest that promising candidate multiple functionalities clinical management.

Language: Английский

Citations

0
Amplification of Metalloregulatory Proteins in Macrophages by Bioactive ZnMn@SF Hydrogels for Spinal Cord Injury Repair DOI
Xiaoliang Cui, Cheng Huang,

Yechen Huang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Macrophages are rapidly activated and polarized toward the M1 phenotype after spinal cord injury (SCI), inhibiting M1-like macrophages has emerged as a promising SCI treatment approach. Metalloregulatory proteins, which sense specific metal ions with high affinity specificity, play critical role in immune regulation. Here, we screened various bioactive associated metalloregulatory proteins discovered that Zn2+ Mn2+ effectively suppressed polarization. Based on these findings, mildly alkaline ZnMn-based layered double hydroxides (ZnMn-LDHs) self-assembled from coordinated were developed to inhibit macrophages. ZnMn-LDHs neutralized acidic environment promoted expression of including metallothionein (MT), superoxide dismutase 1 (SOD1), 2 (SOD2), thereby eliciting robust macrophage inhibition. More importantly, nerve growth factor (NGF) released by following regulation elongation spreading Schwann cells. By integrating silk fibroin (SF), ZnMn@SF injectable hydrogels constructed for repair. An vivo animal model further revealed excellent anti-inflammatory effects treating SCI, functional recovery. Our findings underscore importance regulated macrophages, providing therapeutic strategy treatment.

Language: Английский

Citations

2
Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds DOI
Li Ni, Xiaoyu Zhang,

Jia Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138349 - 138349

Published: Dec. 4, 2024

Language: Английский

Citations

0