Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy DOI
Yang Yue, Wen Zheng, Jiabao Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 8(1), P. 676 - 687

Published: Dec. 30, 2024

A multifunctional nanoplatform integrating multiple therapeutic functions may be an effective strategy to realize satisfactory efficacy in the treatment of tumors. However, there is still a certain challenge agents into single formulation using simple method due variations their properties. In this work, CuS-ICG@PDA-FA nanoparticles (CIPF NPs) with excellent ability produce reactive oxygen species and photothermal conversion performance are fabricated by gentle method. Hollow mesoporous copper sulfide (HMCuS not only have loading but also can cause highly efficient Fenton-like reaction for chemodynamic therapy (CDT). The loaded photosensitizer indocyanine green (ICG) imparts photodynamic properties NPs, which turn enhances stability ICG. polydopamine (PDA) coating improves biocompatibility NPs creates conditions surface modification folic acid. FA-coated show precise targeting tumor cells. results cellular uptake assay demonstrate that CIPF enter cells through endocytic pathway. Lysosome colocalization escape experiments prove possess good lysosomal under irradiation NIR. Both vitro vivo antitumor studies reveal photothermal/photodynamic/chemodynamic therapy. construction high-performance offers valuable insights design sulfide-based combined cancer theranostics.

Language: Английский

Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization DOI
Mennatallah A. Shaheen, Khaled M. Darwish, Safaa M. Kishk

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108153 - 108153

Published: Jan. 11, 2025

Language: Английский

Citations

2
Juvenile Hormone as a contributing factor in establishing midgut microbiota for fecundity and fitness enhancement in adult female Aedes aegypti DOI Creative Commons
Mabel L. Taracena, Ana Beatriz Walter‐Nuno, Vanessa Bottino-Rojas

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: June 5, 2024

Abstract Understanding the factors influencing mosquitoes’ fecundity and longevity is important for designing better more sustainable vector control strategies, as these parameters can impact their vectorial capacity. Here, we address how mating affects midgut growth in Aedes aegypti , what role Juvenile Hormone (JH) plays this process, it impacts mosquito’s immune response microbiota. Our findings reveal that JH induce growth. Additionally, establishment of a native bacterial population due to JH-dependent suppression has reproductive outcomes. Specific downregulation AMPs with an increase bacteria abundance gut results increased egg counts longer lifespans. Overall, provide evidence cross-talk between response, epithelial tissue, cell cycle regulation, mechanisms governing trade-offs nutrition, immunity, reproduction at cellular level mosquito gut.

Language: Английский

Citations

4
Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells DOI Creative Commons
Gayathri Samarasekera,

Nancy E. Go,

Courtney Choutka

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(3), P. e3003034 - e3003034

Published: Feb. 21, 2025

Cell stress adaptation plays a key role in normal development and various diseases including cancer. Caspases are activated response to cell stress, growing evidence supports their function non-apoptotic cellular processes. A for effector caspases promoting stress-induced cytoprotective autophagy was demonstrated Drosophila, but has not been explored the context of human cells. We found functionally conserved caspase 3 (CASP3) 7 (CASP7) starvation or proteasome inhibition-induced breast cancer The loss CASP3 CASP7 resulted an increase PARP1 cleavage, reduction LC3B ATG7 transcript levels, H2AX phosphorylation, consistent with block DNA damage-induced pathways. Surprisingly, non-lethal conditions, underwent non-canonical processing at two calpain cleavage sites flanking exosite, resulting stable CASP7-p29/p30 fragments. Expression fragment(s) could rescue phosphorylation double knockout background. Strikingly, yet these phenotypes, exhibited synthetic lethality BRCA1 loss. These findings support through modulation reveal new therapeutic avenues investigation.

Language: Английский

Citations

0
Regulated cell death in thyroid follicular cells: Molecular insights into pyroptosis, apoptosis, and necrosis DOI

Honghao He,

Daiwei Zhao

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102185 - 102185

Published: March 1, 2025

Language: Английский

Citations

0
Human beta cells become dysfunctional prior to type 1 diabetes diagnosis DOI Creative Commons
Gladys Teitelman

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Type 1 Diabetes is an autoimmune disease that leads to beta cell death. To test whether defects precede diagnosis we surveyed the expression of pCREB in human islet cells. a transcription factor produced by alpha cells regulated incretin Glucagon-Like Peptide (GLP-1). Since levels GLP-1 rise during diabetes development, asked this increase would be deleterious This analysis indicated while control donors display nucleus, was also found cytoplasm insulin normoglycemic prediabetic and recently diagnosed donors. The translocation pCREB, which decreases its activity, correlated with reduced or absent protease. These changes suggest alteration protein homeostasis. cytoplasmic localization transient, since moves nuclei glucagon longer standing disease. present observations possible correlation between known early due cellular pCREB.

Language: Английский

Citations

0
Evaluation of Antifibrotic Mechanisms of 3′5-Dimaleamylbenzoic Acid on Idiopathic Pulmonary Fibrosis: A Network Pharmacology and Molecular Docking Analysis DOI Creative Commons
Karina González-García, Jovito Cesar Santos-Álvarez, Juan Manuel Velázquez-Enríquez

et al.

Drugs and Drug Candidates, Journal Year: 2024, Volume and Issue: 3(4), P. 860 - 878

Published: Dec. 6, 2024

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, disabling disorder of unknown etiology, poor prognosis, and limited therapeutic options. Previously, 3′5-dimaleamylbenzoic acid (3′5-DMBA) was shown to exert resolving effects in IPF, offering promising alternative for treating this disease; however, the molecular mechanisms associated with effect have not been explored. Objetive: We evaluated potential antifibrotic 3′5-DMBA by network pharmacology (NP) docking (MD). Methods: 3′5-DMBA-associated targets were identified screening SwissTargetPrediction. IPF-associated using lung tissue meta-analysis public databases. Common identified, protein–protein interaction (PPI) constructed; we ranked proteins PPI topological analysis. MD validated binding main targets. Results: A total 57 common between IPF; caspase 8, 9, 3, 7; myeloid leukemia-induced cell differentiation protein Mcl-1; poly [ADP-ribose] polymerase 1 are primary regulating networks. Functional analysis revealed that involved pathological features primarily apoptotic process. favorable energies among three Conclusions: NP results suggest due its regulation mainly modulating signaling pathways leading apoptosis, suggesting treat disease.

Language: Английский

Citations

0
Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy DOI
Yang Yue, Wen Zheng, Jiabao Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 8(1), P. 676 - 687

Published: Dec. 30, 2024

A multifunctional nanoplatform integrating multiple therapeutic functions may be an effective strategy to realize satisfactory efficacy in the treatment of tumors. However, there is still a certain challenge agents into single formulation using simple method due variations their properties. In this work, CuS-ICG@PDA-FA nanoparticles (CIPF NPs) with excellent ability produce reactive oxygen species and photothermal conversion performance are fabricated by gentle method. Hollow mesoporous copper sulfide (HMCuS not only have loading but also can cause highly efficient Fenton-like reaction for chemodynamic therapy (CDT). The loaded photosensitizer indocyanine green (ICG) imparts photodynamic properties NPs, which turn enhances stability ICG. polydopamine (PDA) coating improves biocompatibility NPs creates conditions surface modification folic acid. FA-coated show precise targeting tumor cells. results cellular uptake assay demonstrate that CIPF enter cells through endocytic pathway. Lysosome colocalization escape experiments prove possess good lysosomal under irradiation NIR. Both vitro vivo antitumor studies reveal photothermal/photodynamic/chemodynamic therapy. construction high-performance offers valuable insights design sulfide-based combined cancer theranostics.

Language: Английский

Citations

0