Neuron, Journal Year: 2024, Volume and Issue: 113(1), P. 140 - 153
Published: Dec. 27, 2024
Language: Английский
Cell Reports, Journal Year: 2024, Volume and Issue: 43(6), P. 114331 - 114331
Published: June 1, 2024
The choroid plexus (ChP) produces cerebrospinal fluid (CSF). It also contributes to brain development and serves as the CSF-blood barrier. Prior studies have identified transporters on epithelial cells that transport water ions from blood vasculature ventricles tight junctions involved in Yet, how ChP control physiology remains unresolved. We use zebrafish provide insights into physiological roles of ChP. Upon histological transcriptomic analyses, we identify is conserved with mammals expresses CSF secretion. Next, show secrete proteins CSF. By ablating cells, a reduction ventricular sizes without alterations Altogether, our findings reveal size homeostasis ventricles.
Language: Английский
Citations
10
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(8)
Published: Aug. 1, 2024
Abstract Background Idiopathic intracranial hypertension (IIH) mainly affects obese young women, causing elevated pressure, headaches, and papilledema, risking vision loss severe headaches. Despite weight as the primary treatment, underlying mechanisms remain unclear. Recent research explores novel therapeutic targets. Aims This review aimed to provide a comprehensive understanding of IIH's pathophysiology clinical features inform pathogenesis improve treatment strategies. Methods publications on IIH were searched summarized using PubMed, Web Science, MEDLINE. Results The highlights potential pathomechanisms advances in IIH. Conclusion incidence is rising, with growing evidence linking it metabolic hormonal disturbances. Early diagnosis challenging.
Language: Английский
Citations
5
Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(5), P. 1123 - 1136
Published: Feb. 10, 2024
Abstract The brain’s ventricles are filled with a colorless fluid known as cerebrospinal (CSF). When there is an excessive accumulation of CSF in the ventricles, it can result high intracranial pressure, ventricular enlargement, and compression surrounding brain tissue, leading to potential damage. This condition referred hydrocephalus. Hydrocephalus classified into two categories: congenital acquired. Congenital hydrocephalus (CH) poses significant challenges for affected children their families, particularly resource-poor countries. Recognizing psychological economic impacts crucial developing interventions support systems that help alleviate distress burden faced by these families. As our understanding production circulation improves, we gaining clearer insights causes CH. In this article, will summarize current knowledge regarding pathways underlying main CH include abnormalities FoxJ1 pathway cilia, dysfunctions choroid plexus transporter Na + -K -2Cl - contransporter isoform 1, developmental cerebral cortex, structural within brain. Understanding indeed advancing research effective treatment strategies. review, findings from existing studies on propose directions further condition.
Language: Английский
Citations
4
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 5, 2025
In this review, we explore the mechanisms of blood-cerebrospinal fluid (CSF) barrier and CSF transport. We briefly review mathematical framework for transport as described by a set well-studied partial differential equations. Moreover, describe major contributors flow through both diffusive convective forces beginning at molecular level extending into macroscopic clinical observations. addition, neurosurgical perspectives in understanding outflow pathways. Finally, discuss implications dysregulation context neurodegenerative diseases rising role perivascular drainage pathways including glymphatics.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
The principal Ca2 + sensors that control fusion of synaptic vesicles are synaptotagmins 1, 2 and 9. Synaptotagmin 9 (Syt9) has received the least attention. We applied RNAscope techniques to coronal sections adult mouse brain study distribution Syt9 mRNA. Our results showed weak mRNA expression in many regions but elevated levels a handful. Regions strong were largely limbic sensory areas included both excitatory inhibitory neurons. Strongest was medial habenula. interpeduncular nucleus provides input habenula amygdala receives output also Sensory with mitral periglomerular cells olfactory bulb, thalamus, layers superior colliculus. A few putative layer 5 pyramidal somatosensory, auditory visual cortex strongly labeled. Neurons motor including did not generally show exception labeling granular molecular (but Purkinje) cerebellum. Hippocampal neurons only labeling.
Language: Английский
Citations
0
Physiologia, Journal Year: 2024, Volume and Issue: 4(2), P. 182 - 201
Published: April 17, 2024
Hydrocephalus is caused by an overproduction of cerebrospinal fluid (CSF), obstruction movement, or improper reabsorption. CSF accumulation in the brain’s ventricles causes ventriculomegaly, increased intracranial pressure, inflammation, and neural cell injury. can arise from brain trauma, hemorrhage, infection, tumors, genetic mutations. Currently, there no cure for hydrocephalus. Treatments like shunting endoscopic third ventriculostomies are used, but, unfortunately, these therapeutic approaches require surgery have high failure rates. The choroid plexus epithelium (CPe) thought to be major producer brain. It a polarized that regulates ion water movement fenestrated capillary exudate ventricles. Despite decades research, control electrolyte CPe still not fully understood. This review discusses important transporters on CPe, how some regulated, which them could potential targets hydrocephalus treatment. To advance development treatments, physiologically relevant preclinical models crucial. covers current animal culture methods used study highlights need develop standardized multiple investigators order replicate critical findings resolve controversies regarding drug targets.
Language: Английский
Citations
3
Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1315, P. 342812 - 342812
Published: June 1, 2024
Language: Английский
Citations
2
NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)
Published: Sept. 15, 2024
Language: Английский
Citations
2
Published: Jan. 31, 2024
Hydrocephalus is caused by an overproduction of cerebrospinal fluid (CSF), a blockage circulation, or improper reabsorption. CSF accumulation in the brain’s ventricles causes ventriculomegaly and brain cell damage. can be trauma, hemorrhage, infection, tumors, genetic mutations. Currently, there no cure for hydrocephalus. Treatments like shunting endoscopic third ventriculostomies are used, but unfortunately, these techniques require surgery have high failure rates. To advance development hydrocephalus treatments, physiologically relevant pre-clinical models crucial. This review covers some current animal culture methods used to study The choroid plexus epithelium (CPe) thought major producer brain. It polarized that regulates ion water movement from fenestrated capillary exudate ventricles. Despite decades research, control electrolyte CPe still not fully understood. discusses important transporters on how could potential targets treatment.
Language: Английский
Citations
1