Clinical Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: unknown, P. 101888 - 101888
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 22, 2025
Background Epilepsy is a neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. Pirfenidone, an antifibrotic drug, has shown anti-inflammatory and antioxidant properties various disease models, including conditions. However, its potential anticonvulsant effects have not been thoroughly explored. This study aims evaluate of pirfenidone pentylenetetrazol-induced kindling model epilepsy, focusing on effect seizure activity, cognition, profiles, inflammatory markers, neurotransmitter balance, liver enzyme levels, histopathological changes. Methods Healthy male Swiss albino mice were subjected acute Increasing Current Electroshock test chronic pentylenetetrazol-kindling model. Pirfenidone was administered at doses 100, 200, 300 mg/kg, orally, with sodium valproate as standard drug. Seizure severity cognitive function assessed model, along biochemical assays that evaluated enzymes, levels. Histopathological changes also hippocampus cortex experimental mice. Results 200 mg/kg significantly increased Threshold test, indicating protective against seizures. In delayed onset reduced severity, dose showing strongest impact. demonstrated significant improvements function, evidenced enhanced performance passive avoidance elevated plus maze tests. Antioxidant profiles showed levels superoxide dismutase, catalase, glutathione, corresponding reduction malondialdehyde acetylcholinesterase pro-inflammatory cytokines interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, toll-like receptor-4, gamma-aminobutyric acid, decreased glutamate modulated aspartate aminotransferase alanine analysis revealed ameliorated cellular disintegration neuronal damage cortex. Conclusion shows anticonvulsant, anti-inflammatory, hepatoprotective, neuroprotective agent, additional benefits improving cognition oxidative stress epilepsy treatment. Further studies are required explore long-term safety efficacy.
Language: Английский
Citations
1
Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105839 - 105839
Published: Aug. 22, 2024
Language: Английский
Citations
5
ACS Omega, Journal Year: 2025, Volume and Issue: 10(9), P. 9132 - 9153
Published: Feb. 24, 2025
Alzheimer's disease (AD) presents a significant challenge due to cognitive decline resulting from nerve cell degeneration. Shatavarin IV, prominent bioactive compound fromAsparagus racemosus and Piracetam, has been investigated for its neuroprotective potential. This study examines the molecular docking, formulation, characterization of nanoemulsion containing Piracetam IV treating AD. The in silico demonstrated that exhibited strong binding affinities with multiple AD-related targets, including TNF-α (−7.29 kcal/mol), GSK-3 axin complex (−9.6785 amyloid-β (−6.8326 β (−8.8243 kcal/mol). extraction Asparagus roots yielded 401.1 ± 2.3 mg purity 66%, as confirmed by HPTLC. A combination index revealed synergistic effect CI value 0.10843 at 1:1 ratio IV. was optimized using Box-Behnken design, oil concentration, surfactant mixture (Smix), sonication time key factors. formulation particle size 183.6 nm PDI 0.194. Characterization techniques, TEM DSC, uniformity, stability, incorporation drugs nanoemulsion. vitro drug release significantly higher profile (84.30 1.03% 24 h) than suspension. Ex vivo studies superior permeability rate (56.35 1.19%) compared conventional Additionally, showed enhanced antioxidant activity pure extract. Stability indicated remained stable only minor changes size, PDI, zeta potential over time. promising therapeutic strategy
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1563 - 1563
Published: Feb. 26, 2025
Background: Arterial thrombosis (AT), the main clinical manifestations of which are ischemic heart disease (IHD) and stroke (IS), is associated with lowered free triiodothyronine (fT3) in acute (aIS) myocardial infarction (aMI) but increased reverse T3 (rT3) aMI, worse outcomes at one year. Whether such associations remain independent over a longer follow-up period value rT3 aIS largely unknown. This study was dedicated to examining impact fT3 on aMI all-cause mortality 5-year period. Methods: Individuals from Lithuania who experienced aIM were included this study. Serum fT3, rT3, thyroxin thyroid-stimulating hormone values examined admission intensive care department. Follow-up for divided into two time periods: 1 5 years. Results: The final (aIS cohort age, 67.5 ± 9.6 years, 41.5% women 61.8 11.4 28% women) consisted 241 289 individuals, respectively. Lower independently (OR = 0.41; 95% CI: 0.17–0.99, p 0.049) aIS, higher 1.69; 1.06–2.67, 0.027) No found between studied hormones years both conditions. Conclusions:
Language: Английский
Citations
0
Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(12), P. 2565 - 2584
Published: Aug. 19, 2024
Abstract Rationale Major depression has been an area of extensive research during the last decades, for it represents a leading cause disability and suicide. The stark rise rates influenced by life stressors, economic threats, pandemic era, resistance to classical treatments, made disorder rather challenging. Adult hippocampal neurogenesis plasticity are particularly sensitive dynamic interplay between autophagy inflammation. In fact, intricate balance two processes contributes neuronal homeostasis survival. Objectives Having demonstrated promising potentials in AMPK activation, major metabolic sensor regulator, empagliflozin (Empa) was investigated possible antidepressant properties reserpine rat model depression. Results While protocol elicited behavioral, biochemical, histopathological changes relevant depression, Empa outstandingly hindered these pathological perturbations. Importantly, autophagic response markedly declined with which disrupted AMPK/mTOR/Beclin1/LC3B machinery and, conversely, neuro-inflammation prevailed under influence NLRP3 inflammasome together oxidative/nitrative stress. Consequently, AMPK-mediated neurotrophins secretion obviously deteriorated through PKCζ/NF-κB/BDNF/CREB signal restriction. restored monoamines autophagy/inflammation balance, driven activation. By promoting atypical PKCζ phosphorylation (Thr403) subsequently phosphorylates NF-κB at Ser311, successfully reinforced BDNF/CREB neuroplasticity. latter finding supported CA3 toluidine blue staining reveal intact neurons. Conclusion current study highlights interesting role as regulator inflammatory responses pathology also pinpoints unusual contribution via AMPK/PKCζ/NF-κB/BDNF/CREB transduction. Accordingly, can have special benefits diabetic patients depressive symptoms. Limitations p -NF-κB (Ser311) on assembly activation not investigated, represent point further research. Graphical abstract
Language: Английский
Citations
3
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 199, P. 106598 - 106598
Published: July 11, 2024
Myocardial infarction (MI) and depression are leading causes of mortality morbidity globally, these conditions increasing recognized as being fundamentally interconnected. The recently gut-heart-brain axis offers insights into following MI, but effective treatments for this comorbidity remain lacking. To address medical need, we employed an animal model MI to investigate the potential repurposing sotagliflozin (SOTA), approved sodium-glucose cotransporter 1 2 (SGLT1/2) inhibitor diabetes, managing identifying SOTA-associated microbial mechanisms. SOTA treatment improved cardiac dysfunction alleviated depression-like behaviors induced by accompanied alterations in gut microbiota composition, such changes Prevotellaceae NK3B31 group, Alloprevotella, UCG-001. Moreover, fecal transplantation (FMT) using samples from SOTA-treated mice demonstrated that contributed beneficial effects on mice. Intriguingly, FMT-based intervention concordance analysis before after FMT suggested UCG-001 were associated with SOTA. Furthermore, functional prediction correlation support significance dynamic communities. In conclusion, findings suggest could serve a drug ameliorate depressive symptoms patients via through axis.
Language: Английский
Citations
2
Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: 56(12), P. 845 - 858
Published: Aug. 19, 2024
Insulin and thyroid hormones play important roles in our body. helps regulate the glucose level while affect various cells tissues, metabolizing protein, lipids, glucose. Hyperthyroidism thyrotoxicosis are potential hazards for type 2 diabetes mellitus. There is a high prevalence of hypothyroidism being more common compared to hyperthyroidism coexisting with Thyroid metabolism through its action on peripheral tissues (gastrointestinal tract, liver, skeletal muscles, adipose tissue, pancreas). High-level hormone causes hyperglycemia, upregulation transport, reduction glycogen storage. The reverse observed during low levels along insulin clearance. net result disorder resistance. Type mellitus can downsize regulation stimulating impair conversion thyroxine triiodothyronine tissues. Furthermore, poorly managed may resistance hyperinsulinemia, contributing proliferation tissue an increase nodule formation goiter size. Although metformin proves advantageous both patients, other antidiabetics like sulfonylureas, pioglitazone, thiazolidinediones have adverse effects disorders. Moreover, antithyroid drugs such as methimazole weaken glycemic control individuals diabetes. Thus, interplay between endocrinopathies individualized care management needs be facilitated.
Language: Английский
Citations
2
Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(2), P. 2055 - 2064
Published: July 12, 2024
Language: Английский
Citations
1
Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(14), P. 1953 - 1960
Published: Sept. 21, 2024
Polycystic ovarian syndrome (PCOS) has been a common metabolic and endocrinal disorder, prevalent amongst women belonging to the reproductive age group. The aim of this systematic review was assess safety efficacy profile sodium-glucose cotransporter 2 (SGLT2) inhibitors (Canagliflozin, Dapagliflozin, Empagliflozin, Licogliflozin) for treatment suffering from PCOS.
Language: Английский
Citations
1
Clinical Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: unknown, P. 101888 - 101888
Published: Dec. 1, 2024
Language: Английский
Citations
0