Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115239 - 115239

Published: March 3, 2024

Language: Английский

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Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 447 - 447

Published: Jan. 20, 2024

Introduced almost two decades ago, ADCs have marked a breakthrough in the targeted therapy era, providing clinical benefits to many cancer patients. While inherent complexity of this class drugs has challenged their development and broad application, experience gained from years trials errors recent advances construct design delivery led an increased number approved or late only five years. Target payload diversification, along with novel conjugation linker technologies, are at forefront next-generation ADC development, renewing hopes broaden scope these difficult-to-treat cancers beyond. This review highlights trends field, focusing on mechanism action implications ADCs’ therapeutic profile. The evolution conventional innovative formats will be illustrated, some current hurdles, including toxicity drug resistance. Future directions improve also presented.

Language: Английский

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Nanotechnology Reprogramming Metabolism for Enhanced Tumor Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 1846 - 1864

Published: Jan. 5, 2024

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in tumor cells, resulting a microenvironment (TME) characterized by accumulation of toxic metabolites depletion various nutrients, which significantly hinder the antitumor immunity via multiple mechanisms, hindering efficacy immunotherapies. In-depth investigation mechanisms underlying these phenomena are vital for developing effective drugs therapies, while therapeutic effects metabolism-targeting restricted off-target toxicity toward effector immune cells high dosage-mediated side effects. Nanotechnologies, exhibit versatility plasticity targeted delivery metabolism modulation, have been widely applied boost immunometabolic therapies strategies, including targeting pathways. In this review, recent advances understanding roles cell both immunoevasion immunosuppression reviewed, nanotechnology-based reprogramming strategies enhanced immunotherapies discussed.

Language: Английский

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Targeted Protein Degradation in Cancer Therapy via Hydrophobic Polymer-Tagged Nanoparticles

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Targeted protein degradation (TPD) strategies offer a significant advantage over traditional small molecule inhibitors by selectively degrading disease-causing proteins. While molecules can lead to recurrence and resistance due compensatory pathway activation, TPD addresses this limitation promoting degradation, thereby reducing the likelihood of long-term. Despite these benefits, bifunctional face challenges such as low solubility, poor bioavailability, limited tumor specificity. In study, we developed polymer-based nanoparticles that combine with nanotechnology through hydrophobic tagging method. Hydrophobic polymer-tagged facilitate targeted incorporating polymers mimic residues in misfolded This system combines delivery capabilities within platform, inducing while improving stability, targeting. These consist block copolymer composed an androgen receptor ligand (ARL)-conjugated polylactic acid (PLA) hydrophilic polyethylene glycol (PEG), connected GSH-cleavable disulfide bond. aqueous solutions, (ARL-PLA-SS-PEG) forms micelles degrade reducible cellular environments. The demonstrated vitro target (AR). Furthermore, they achieved substantial accumulation significantly inhibited growth tumor-bearing mouse model. A mechanistic study revealed micelle-mediated follows dual involving both proteasome autophagosome. approach has potential serve universal platform for eliminating need develop disease-specific molecules.

Language: Английский

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Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: Aug. 16, 2021

Abstract Covalent organic frameworks (COFs) as a type of porous and crystalline covalent polymer are built up from covalently linked periodically arranged molecules. Their precise assembly, well-defined coordination network, tunable porosity endow COFs with diverse characteristics such low density, high crystallinity, structure, large specific-surface area, well versatile functions active sites that can be tuned at molecular atomic level. These unique properties make them excellent candidate materials for biomedical applications, drug delivery, diagnostic imaging, disease therapy. To realize these functions, the components, dimensions, guest molecule loading into have great influence on their performance in various applications. In this review, we first introduce building blocks, synthetic conditions chemical stability, pore interaction molecules COFs. Next, applications cancer diagnosis therapy summarized. Finally, some challenges noted problems to solved future proposed.

Language: Английский

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Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 617, P. 704 - 717

Published: March 11, 2022

Heterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding tumor microenvironment reactor with very specific chemical features provided perspective in search catalytic nanoarchitectures action against species playing key role metabolism. One these is glutathione (GSH), whose depletion cornerstone emerging strategies oncology, since this metabolite plays pivotal regulatory antioxidant agent, dampening harmful effects intracellular reactive oxidative (ROS). Herein, we present copper-iron oxide spinel nanoparticles that exhibit versatile and selective response to reduce GSH levels while generating ROS cascade reaction. We demonstrate clear correlation between apoptotic cell death cells presence nanocatalyst. Furthermore, also provide novel analytical protocol, state-of-the-art commercial kits, accurately monitoring concentration both healthy cells. observe nanoparticles, lower toxicity lines, intrinsic are lower, intense apoptosis accompanied by fast reduction levels.

Language: Английский

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Nanomedicine Strategies for Heating “Cold” Ovarian Cancer (OC): Next Evolution in Immunotherapy of OC

Advanced Science, Journal Year: 2022, Volume and Issue: 9(28)

Published: July 22, 2022

Immunotherapy has revolutionized cancer treatment, dramatically improving survival rates of melanoma and lung patients. Nevertheless, immunotherapy is almost ineffective against ovarian (OC) due to its cold tumor immune microenvironment (TIM). Many traditional medications aimed at remodeling TIM are often associated with severe systemic toxicity, require frequent dosing, show only modest clinical efficacy. In recent years, emerging nanomedicines have demonstrated extraordinary immunotherapeutic effects for OC by reversing the because physical biochemical features can all be harnessed obtain optimal expected tissue distribution cellular uptake. However, far from being widely explored in field lack appreciation professional barriers nanomedicine pathology, limiting horizons biomedical researchers materials scientists. Herein, a typical tumor-OC adopted as paradigm introduce classification TIM, characteristics OC, advantages immunotherapy. Subsequently, current comprehensively summarized through five general strategies substantially enhance efficacy heating OC. Finally, challenges perspectives this expanding improved development applications also discussed.

Language: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

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Stimuli‐Responsive Organic Near‐Infrared Photoacoustic Probes

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: Feb. 10, 2023

Abstract Photoacoustic (PA) imaging is an emerging biomedical technique with the features of non‐invasiveness and non‐ionization. It takes advantage photothermal effect PA probes to convert absorbed photon energy into heat subsequent transient thermoelastic tissue expansion for ultrasonic waves images. Thus, exhibits combined superiority high‐contrast optical deep penetration acoustic imaging, which furnishes high‐resolution Stimuli‐responsive organic agents in near‐infrared (NIR) biological window have attracted increasing attention because their low toxicity response characteristics. This review focuses on recent research progress stimuli‐responsive NIR including temperature response, pH redox metal ion enzyme response. And mechanisms are highlighted detail. Moreover, perspectives challenges discussed. will be great help further development stimuli‐response.

Language: Английский

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