Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(8)
Published: Aug. 3, 2024
Sharply
increased
reactive
oxygen
species
(ROS)
are
thought
to
induce
oxidative
stress,
damage
cell
structure
and
cause
death;
however,
its
role
in
prostate
cancer
remains
unclear.
Enzalutamide
is
a
widely
used
anti-prostate
drug
that
antagonizes
androgen
binding
with
receptor.
Further
exploration
of
the
mechanism
potential
application
strategies
enzalutamide
crucial
for
treatment
cancer.
Here,
we
confirmed
PEX10
can
be
induced
by
ROS
activators
while
reduce
level
cells,
which
weakened
anti-tumor
effect
activators.
The
receptor
(AR)
promote
expression
acting
as
an
enhancer
cooperation
FOXA1.
inhibits
inhibiting
function
AR,
synergize
ML210
or
RSL3
produce
stronger
effect,
thereby
sensitizing
cells
This
study
reveals
previously
unrecognized
AR
regulating
suggests
new
strategy
treatment.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 26, 2024
Carbon
dots
(CDs)
are
novel
carbon-based
nanomaterials
that
have
been
used
as
photosensitizer-mediated
photodynamic
therapy
(PDT)
in
recent
years
due
to
their
good
photosensitizing
activity.
Photosensitizers
(PSs)
main
components
of
PDT
can
produce
large
amounts
reactive
oxygen
species
(ROS)
when
stimulated
by
light
source,
which
the
advantages
low
drug
resistance
and
high
therapeutic
efficiency.
CDs
generate
ROS
efficiently
under
irradiation
therefore
extensively
studied
disease
local
phototherapy.
In
tumor
therapy,
be
PSs
or
PS
carriers
participate
play
an
extremely
important
role.
bacterial
infectious
diseases,
exhibit
bactericidal
activity
effective
disrupting
cell
membranes
leading
death
upon
photoactivation.
We
focus
on
advances
cancer
bacteria
with
CDs,
also
briefly
summarize
mechanisms
requirements
for
cancer,
other
diseases.
discuss
role
combination
potential
future
applications
against
pathogens.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(21), P. 14875 - 14888
Published: May 15, 2024
Most
of
the
nanozymes
have
been
obtained
based
on
trial
and
error,
for
which
application
is
usually
compromised
by
enzymatic
activity
regulation
due
to
a
vague
catalytic
mechanism.
Herein,
hollow
axial
Mo–Pt
single-atom
nanozyme
(H-MoN5@PtN4/C)
constructed
two-tier
template
capture
strategy.
The
ligand
can
induce
Mo
4d
orbital
splitting,
leading
rearrangement
spin
electrons
(↑
↑
→
↑↓)
regulate
activity.
This
creates
catalase-like
enhances
oxidase-like
catalyze
cascade
reactions
(H2O2
O2
O2•–),
overcome
tumor
hypoxia
accumulate
cytotoxic
superoxide
radicals
(O2•–).
Significantly,
H-MoN5@PtN4/C
displays
destructive
d−π
conjugation
between
metal
substrate
attenuate
restriction
orbitals
electrons.
markedly
improves
performance
(catalase-like
activity)
single
atom
peroxidase-like
properties
Pt
atom.
Furthermore,
deplete
overexpressed
glutathione
(GSH)
through
redox
reaction,
avoid
consumption
ROS
(O2•–
•OH).
As
result,
limitations
complex
microenvironment
(TME)
tumor-specific
therapy
TME-activated
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(3), P. 1088 - 1112
Published: Jan. 29, 2024
Cancer
immunotherapy,
aimed
at
reinvigorating
the
immune
system
to
induce
a
lasting
anticancer
response,
has
emerged
as
promising
approach
for
counteracting
evasive
tactics
of
cancer
cells.
This
study
delves
into
innovative
realm
stimuli-responsive
polymeric
nanomedicines
in
context
immunotherapy.
By
capitalizing
on
intricate
landscape
tumor
microenvironment
(TME),
which
orchestrates
suppression
and
progression,
offer
tailored
strategy
enhance
therapeutic
interventions.
The
aberrant
features
TME,
include
factors
such
low
pH,
inflammation,
oxidative
stress,
enzyme
overexpression,
serve
triggers
intelligent
delivery
systems
facilitated
by
functional
polymers.
dynamic
potential
overcome
challenges
faced
traditional
nanoparticle-based
immunotherapy
techniques,
presenting
platform
precisely
optimize
drug
within
locale.
As
synergistic
interaction
between
TME
unfolds,
novel
horizon
emerges
advance
efficacy
while
mitigating
its
associated
limitations.
