Recent developments of Red/NIR carbon dots in biosensing, bioimaging, and tumor theranostics

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 465, P. 143010 - 143010

Published: April 18, 2023

Language: Английский

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Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Polymers, Journal Year: 2022, Volume and Issue: 14(11), P. 2153 - 2153

Published: May 25, 2022

Although there is significant progress in the research of carbon dots (CDs), some challenges such as difficulty large-scale synthesis, complicated purification, low quantum yield, ambiguity structure-property correlation, electronic structures, and photophysics are still major obstacles that hinder commercial use CDs. Recent advances modification, characterization, applications CDs summarized this review. We illustrate examples to correlate process parameters, compositions, properties, performances CDs-based materials. The synthesis approach, purification methods, modification/doping methods for also presented. Moreover, kilogram-scale fabrication given. properties performance can be tuned by incubation time precursor ratio, laser pulse width, average molar mass polymeric precursor. Surface passivation has a influence on particle sizes factors affect CDs, polarity-sensitive fluorescence effect concentration-dependent multicolor luminescence, together with size surface states synchrotron near-edge X-ray absorption fine structure (NEXAFS) test been proved useful tool explore correlation among structural features, photophysics, emission bioimaging, sensing, therapy, energy, fertilizer, separation, security authentication, food packing, flame retardant, co-catalyst environmental remediation were reviewed article. Furthermore, roles doped their composites these demonstrated.

Language: Английский

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Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(23), P. 3383 - 3398

Published: Jan. 1, 2023

This review aims to provide an overview of recent advances in the field functional peptide-based biosensing cancer biomarkers. Particular attention is focused on use electrochemical and optical techniques.

Language: Английский

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Recent developments in carbon dots: a biomedical application perspective

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(14), P. 3038 - 3053

Published: Jan. 1, 2023

Recently, newly developed carbon-based nanomaterials known as carbon dots (CDs) have generated significant interest in nanomedicine.

Language: Английский

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Combined Ultrasensitive Detection of Renal Cancer Proteins and Cells Using an Optical Microfiber Functionalized with Ti₃C₂ MXene and Gold Nanorod-Nanosensitized Interfaces

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(11), P. 5142 - 5150

Published: March 9, 2023

The ultrasensitive and quantitative detection of renal cancer protein biomarkers present at ultralow concentrations for early-stage diagnosis requires a biosensing probe possessing ultrahigh sensitivity remarkable selectivity. Here, we report an optical microfiber integrated with Ti3C2-supported gold nanorod hybrid nanointerfaces implementation in sensing the carbonic anhydrase IX (CAIX) cells. Because evanescent field fiber is strongly coupled near-infrared region, proposed biosensor achieves ultrahigh-sensitivity CAIX biomarker limits (LODs) 13.8 zM pure buffer solution 0.19 aM 30% serum solution. In addition, sensor also successfully specifically recognizes living cells cell culture media LOD 180 cells/mL. This strategy may serves as powerful platform that combines quantification cells, resulting higher accuracy screenings.

Language: Английский

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Multi-modal nanoprobe-enabled biosensing platforms: a critical review

Nanoscale, Journal Year: 2024, Volume and Issue: 16(8), P. 3784 - 3816

Published: Jan. 1, 2024

Multi-modal nanoprobes can realize multiple signal outputs, promoting the development of multi-modal sensors for a wide range applications.

Language: Английский

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Carbon‐based nanodots for biomedical applications and clinical transformation prospects

BMEMat, Journal Year: 2024, Volume and Issue: 2(3)

Published: May 11, 2024

Abstract Carbon dots (CDs), emerging as a promising class of nanomaterials, have garnered significant interest in the field biomedicine due to their unique physicochemical properties. This review provides comprehensive overview recent advancements biomedical applications CDs, emphasizing potential for revolutionizing diagnostics, therapy, and bio‐imaging. We discuss synthesis functionalization which are pivotal tailoring properties specific applications. The CDs bioimaging include fluorescence imaging, magnetic resonance photoacoustic etc. Additionally, this delves into benefits treatment diseases including cancer, inflammation Alzheimer's, Finally, we look forward future biomedicine, necessity interdisciplinary collaboration overcome current obstacles facilitate clinical translation CDs‐based technologies. aims provide summary perspectives on latest developments hoping inspire further research rapidly advancing field.

Language: Английский

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Targeted nanomedicine modulating intercellular communications to arrest renal cell carcinoma progression

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105983 - 105983

Published: July 20, 2024

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Engineered aptamers for molecular imaging

Chemical Science, Journal Year: 2023, Volume and Issue: 14(48), P. 14039 - 14061

Published: Jan. 1, 2023

Molecular imaging, including quantification and molecular interaction studies, plays a crucial role in visualizing analysing events occurring within cells or organisms, thus facilitating the understanding of biological processes. Moreover, imaging offers promising applications for early disease diagnosis therapeutic evaluation. Aptamers are oligonucleotides that can recognize targets with high affinity specificity by folding themselves into various three-dimensional structures, serving as ideal recognition elements imaging. This review summarizes commonly employed aptamers outlines prevalent design approaches their applications. Furthermore, it highlights successful application to wide range modalities. Finally, concludes forward-looking perspective on future advancements aptamer-based

Language: Английский

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Carbon nanodots constructed by ginsenosides and their high inhibitory effect on neuroblastoma

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 28, 2023

Neuroblastoma is one of the common extracranial tumors in children (infants to 2 years), accounting for 8 ~ 10% all malignant tumors. Few special drugs have been used clinical treatment currently.In this work, herbal extract ginsenosides were synthesize fluorescent carbon nanodots via a one-step hydrothermal method. At low cocultured concentration (50 µg·mL- 1) nanodots, inhibition rate and apoptosis SH-SY5Y cells reached 45.00% 59.66%. The vivo experiments showed tumor volume weight mice group 49.81% 34.14% model group. Since as sole reactant, toxicity good animal response.Low-cost new type nanomedicine with curative effect little show application prospects neuroblastoma. It proposed design based on bioactive which natural molecules source.

Language: Английский

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