Impact of the diseased lung microenvironment on the in vivo fate of inhaled particles DOI

Jiayi Gai,

Liu Liu, Xin Zhang

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 104019 - 104019

Published: May 8, 2024

Language: Английский

RNA-cleaving DNAzymes for accurate biosensing and gene therapy DOI
Xin Gao,

Y Liu,

Wendi Huo

et al.

Nanoscale, Journal Year: 2023, Volume and Issue: 15(27), P. 11346 - 11365

Published: Jan. 1, 2023

The review systematically summarizes the applications of RNA-cleaving DNAzymes in recent years, explaining uniqueness and superiority biosensing gene therapy.

Language: Английский

Citations

11
Construction and performance evaluation of pH-responsive oxidized hyaluronic acid hollow mesoporous silica nanoparticles DOI

Xu Enyu,

Xinbo Liu, Xuelian Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 257, P. 128656 - 128656

Published: Dec. 6, 2023

Language: Английский

Citations

11
A pH transformable nanocarrier for gradual and precise delivery of a natural immunomodulator and chemotherapy agent to trigger tumor apoptosis DOI

Qianwen Sun,

Wei Chen, Qi Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153209 - 153209

Published: June 21, 2024

Language: Английский

Citations

4
Bioresponsive nanoreactor initiates cascade reactions for tumor vascular normalization and lactate depletion to augment immunotherapy DOI

Jiaoyu Chen,

Charlie Bu, Yuting Lu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123100 - 123100

Published: Jan. 9, 2025

Language: Английский

Citations

0
Advancing Tumor Microenvironment Analysis: A Fluorescence Nanosystem for Caspase-1 Monitoring and Synergistic Therapy DOI
Chen Zhao,

Mo Ma,

Jukun Yang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

The lack of precise, real-time analytical tools for monitoring tumor microenvironment changes during treatment hinders advancements in integrated diagnostic and therapeutic platforms. Traditional caspase-3 strategies are limited by their inability to address drug resistance newly discovered apoptotic pathways, leading reduced accuracy practicality. To overcome these limitations, we developed a fluorescence-based "Trojan horse" nanosystem, PFpR@CM, featuring high-sensitivity Caspase-1 detection, tumor-targeted delivery, photothermal therapy. was selected as biomarker due its ability provide accurate feedback on reactive oxygen species (ROS) generation. system employs Fe-doped polydopamine nanoparticles red fluorescent carbon quantum dots (RCQDs) the core, achieving detection limit 0.024 U/mL with linear range 0.05-1.0 U/mL. By integrating MG-63 cell membrane camouflage, PFpR@CM ensures specificity immune evasion, allowing precise situ ROS production ferroptosis. Experimental results demonstrate that enables simultaneous fluorescence tracking localized interventions, over 80% volume reduction vivo minimal systemic toxicity. This work establishes novel chemistry approach multifunctional treatment, providing an innovative solution challenges precision oncology.

Language: Английский

Citations

0
Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy DOI

Sonia Iranpour,

Amir Abrishami, Amir Sh. Saljooghi

et al.

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development? DOI Creative Commons
Sheik Aliya, Munirah Alhammadi,

S Ilangovan

et al.

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance DOI
Xinyi Ding, Yiyu Liang, Siyuan Zhou

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113786 - 113786

Published: April 1, 2025

Language: Английский

Citations

0
Manipulating the Crosstalk between Cancer and Immunosuppressive Cells with Phototherapeutic Gold‐Nanohut for Reprogramming Tumor Microenvironment DOI
Hung‐Wei Cheng, Wei Lee, Fei‐Ting Hsu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 23, 2024

Abstract Photoimmunotherapy faces challenges due to insufficient intratumoral accumulation of photothermal agents and the reversion cancer‐immunity cycle during treatment. In this study, an anti‐PD‐L1‐immobilized magnetic gold nanohut, AuNH‐2‐Ab, with photoresponsive, thermosensitive, immunomodulatory properties effectively suppress growth primary tumors, elevate immunogenic cell death (ICD) levels, reverse tumor immune microenvironment (TIME), consequently inhibit metastases are developed. AuNH‐2‐Ab achieves high (9.54% injected dose) following systemic administration, allowing modulation hyperthermia dose over 50 °C in tumor. By optimizing dose, simultaneously target eliminate cancer cells tumor‐associated macrophages, thereby activating potent antitumor immunity without being compromised by immunosuppressive elements. Hyperthermia/pH induced morphological transformation involving detachment surface antibody for situ PD‐L1 inhibition, exposure inner fucoidan layer natural killer (NK) activation. This precision photoimmunotherapy approach reprograms TIME, significantly prolongs survival a murine hepatocellular carcinoma model (Hep55.1c), harnesses synergistic effects ICD production checkpoint inhibitors utilizing single nanoplatform.

Language: Английский

Citations

3
Organ-selective lipid nanoparticles for precise cancer therapy: Beyond liposomes and polymeric micelles DOI
Xu Huang, Yan Ding,

Jia Ming Gu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153171 - 153171

Published: June 15, 2024

Language: Английский

Citations

2