A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100282 - 100282

Published: Aug. 30, 2024

Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome bone limited, due to the inaccessibility of metastatic site complexity metastasis. Herein, we reported simple nanoplatform composed thermo-sensitive liposomes (TSL) gold nanorods (GNR) treat through improved chemotherapy combined with GNR-assisted PTT. Lipid combination TSL was firstly tailored regulate its stability under physiological condition as well sensitivity responding PTT-caused mild hyperthermia. The obtained loaded then GNR form unsophisticated incubation. Cell experiments revealed that upon near-infrared (NIR) irradiation, effectively inhibited viability migration ability tumor cells PTT, PTT-triggered release, PTT-augmented drug. In murine model metastasis, enabled effective for rapid release local NIR irradiation. Through killing rebalancing turnover osteoclasts osteoblasts, largely preserved structure pain relief survival extension. Inspired by simplicity acquirement treatment operation, strategy liposomes-based PTT greatly promising

Language: Английский

Metal Complexation for the Rational Design of Gemcitabine Formulations in Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56789 - 56800

Published: Oct. 8, 2024

Nanoformulation of chemotherapies represents a promising strategy to enhance outcomes in cancer therapy. Gemcitabine is chemotherapeutic agent approved by the Food and Drug Administration for treatment various solid tumors. Nevertheless, its therapeutic effectiveness constrained poor metabolic stability pharmacokinetic profile. Nanoformulations gemcitabine lipid polymer nanocarriers usually lead loading capability an inability effectively control release profile due physicochemical characteristics drug matrices. Here, we propose metal-gemcitabine complexation with biorelevant metal cations as alter properties noncovalent manner, paving way development novel nanoformulations. A speciation study on Mn

Language: Английский