Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(34)
Published: April 13, 2024
Abstract
The
peroxidase
(POD)‐mimic
nanozymes
can
be
a
potential
tool
for
point‐of‐care
(POC)
diseases
diagnosis.
However,
the
complex
sample
matrix
and
unspecific
multiple‐enzyme
activities
of
nanozyme
generate
false
background
signal
decrease
diagnostic
accuracy.
Here,
magnetic
POD‐specific
covalent
organic
framework
(COF)
confined
osmium
(Os)
nanoclusterzyme
Fe
3
O
4
@COF@Os
is
developed
biomarkers
biosensing.
First,
found
that
catalytic
activity
specificity
regulated
by
deoxidizers
functional
groups
COF
ligands.
By
using
ascorbic
acid
as
deoxidizer
F
ligands,
displayed
superior
negligible
oxidase
(OXD)
catalase
(CAT)
mimic
activity.
Therefore,
separate
analyze
targets
in
bio‐matrix
without
interference.
For
application,
based
lateral
flow
assay
established
serum
cancer
biomarker
prostate‐specific
antigen,
detection
limit
3.83
pg
mL
−1
.
clinical
prostatic
samples,
accuracy
100%
with
correlation
coefficient
0.998
commercial
ELISA
kit.
chronic
disease
sensing,
salivary
glucose
quantified
low
0.1
µ
m
,
interference
favorable
recyclability.
This
specific
offer
promising
pretreatment‐free
POC
strategy
rapid
accurate
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(8), P. 3840 - 3847
Published: July 31, 2024
Single-atom
nanozymes
(SANs)
have
become
a
breakthrough
in
atomically
precise
catalysis,
which
relies
on
the
catalytic
active
site
formed
by
single-atom
itself.
From
this
angle,
SANs
and
their
advantages
compared
to
natural
enzymes
as
well
spaces
for
application
are
emphasized.
The
outstanding
control
over
activities;
is
with
bulk
materials
enzymes.
structure
of
has
very
promising
potential
next
generation
biosensing
biomedical
devices
environmental
remediation.
Although
capabilities
high,
difficulties
still
arise.
specificity,
scalability,
biosafety,
catalysis
mechanisms
raise
additional
issues
that
require
further
research.
We
build
up
vision
perspectives
better
implementation
SANs,
designed
diagnostic
purposes,
improving
industrial
technologies,
creating
new
sustainable
technologies
food
processing
industry.
AI
machine
learning
systems
may
clarify
structure–performance
relationship
improved
material
process
selectivity.
future
promising,
addressing
these
challenges
leveraging
advancements
artificial
intelligence
science,
powerful
tools
future.
Inorganic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(15), P. 4289 - 4312
Published: Jan. 1, 2023
Single-atom
nanozymes
represent
a
unique
class
of
enzyme
mimics
that
exhibit
maximal
atomic
utilization,
well-defined
electronic/geometric
structure,
and
high
catalytic
activity,
have
found
diverse
applications
in
biomedicine
biosensing.
Biomimetics,
Journal Year:
2023,
Volume and Issue:
8(5), P. 446 - 446
Published: Sept. 21, 2023
Nanozymes
represent
a
category
of
nano-biomaterial
artificial
enzymes
distinguished
by
their
remarkable
catalytic
potency,
stability,
cost-effectiveness,
biocompatibility,
and
degradability.
These
attributes
position
them
as
premier
biomaterials
with
extensive
applicability
across
medical,
industrial,
technological,
biological
domains.
Following
the
discovery
ferromagnetic
nanoparticles
peroxidase-mimicking
capabilities,
research
endeavors
have
been
dedicated
to
advancing
nanozyme
utilization.
Their
capacity
emulate
functions
natural
has
captivated
researchers,
prompting
in-depth
investigations
into
potential
applications.
This
exploration
yielded
insights
innovations
in
various
areas,
including
detection
mechanisms,
biosensing
techniques,
device
development.
exhibit
diverse
compositions,
sizes,
forms,
resembling
molecular
entities
such
proteins
tissue-based
glucose.
rapid
impact
on
body
necessitates
comprehensive
understanding
intricate
interplay.
As
each
day
witnesses
emergence
novel
methodologies
technologies,
integration
nanozymes
continues
surge,
promising
enhanced
comprehension
times
ahead.
review
centers
expansive
deployment
advancement
materials,
encompassing
biomedical,
biotechnological,
environmental
contexts.
